PERFLUBRODEC

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10BrF21
Molecular Weight	598.977
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)Br

InChI

InChIKey=JCAULFRGWRHHIG-UHFFFAOYSA-N

InChI=1S/C10BrF21/c11-9(28,29)7(24,25)5(20,21)3(16,17)1(12,13)2(14,15)4(18,19)6(22,23)8(26,27)10(30,31)32

HIDE SMILES / InChI

Molecular Formula	C10BrF21
Molecular Weight	598.977
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11094488
Curator's Comment: Description was created based on several sources, including http://adisinsight.springer.com/drugs/800007599 | https://www.pharmaceuticalonline.com/doc/alliance-pharmaceutical-baxter-to-collaborate-0001

PERFLUBRODEC is a component of an artificial perfluorochemical-based oxygen carrier OXYGENT. Using solely 3.6%w/v egg yolk phospholipid, Alliance Pharmaceutical Corporation (San Diego, California, USA) developed a concentrated (60% w/v) and stable perfluorocarbon emulsion, OXYGENT, which is composed of 58% w/v perfluorooctyl bromide and 2% w/v perfluorodecyl bromide, with an average particle size of 0.16-0.18 μm diameter. As a blood substitute OXYGENT has been administered to patients undergoing surgeries in clinical trials, however development was discontinued.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypoxia 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11094488 http://adisinsight.springer.com/drugs/800007599	Preventing		Phase III 656	OXYGENT Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
Apollo Scientific	PC450264	http://www.apolloscientific.co.uk/chemical_results.php?qstext=PC450264&product_group=%25&search_fieldname=header_search
BOC Sciences	307-43-7	http://www.bocsci.com/description.asp?cas=307-43-7
Combi-Blocks	QC-0607	http://www.combi-blocks.com/cgi-bin/find.cgi?QC-0607
Compound Cloud	9389
Hairui	HR103294	http://www.hairuichem.com/en/product/search.do?q=HR103294
MolPort	MolPort-006-111-189	https://www.molport.com/shop/molecule-link/MolPort-006-111-189
SynQuest	1100-A-28	http://www.synquestlabs.com/search-result.html?q=1100-A-28
SynQuest	55789	http://www.synquestlabs.com/search-result.html?q=55789
Toronto Research Chemicals	P999350	https://www.trc-canada.com/product-detail/?CatNum=P999350
eMolecules	44386038	https://orderbb.emolecules.com/search/#?query=44386038
mcule	MCULE-6607343070	https://mcule.com/MCULE-6607343070/

PubMed

Title	Date	PubMed
Mixed fluorocarbon/hydrocarbon molecular dowels help protect concentrated fluorocarbon emulsions with large size droplets against coalescence.	1994	7849932
Cosurfactant effect of a semifluorinated alkane at a fluorocarbon/water interface: impact on the stabilization of fluorocarbon-in-water emulsions.	2004 May 11	15969380

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:47:40 GMT 2023` Edited by `admin` on `Fri Dec 15 15:47:40 GMT 2023`
Record UNII	4818HEA280
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PERFLUBRODEC

Official Name

English

DECANE, 1-BROMO-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-HENEICOSAFLUORO-

Systematic Name

English

PERFLUBRODEC [USAN]

Common Name

English

AF-0144

Code

English

perflubrodec [INN]

Common Name

English

1-Bromoheneicosafluorodecane

Systematic Name

English

AF0144

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C314