D&C RED NO. 6

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H12N2O6S.2Na
Molecular Weight	430.342
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].CC1=CC=C(\N=N\C2=C3C=CC=CC3=CC(C([O-])=O)=C2O)C(=C1)S([O-])(=O)=O

InChI

InChIKey=VPWFPZBFBFHIIL-LLIZZRELSA-L

InChI=1S/C18H14N2O6S.2Na/c1-10-6-7-14(15(8-10)27(24,25)26)19-20-16-12-5-3-2-4-11(12)9-13(17(16)21)18(22)23;;/h2-9,21H,1H3,(H,22,23)(H,24,25,26);;/q;2*+1/p-2/b20-19+;;

HIDE SMILES / InChI

Molecular Formula	C18H12N2O6S
Molecular Weight	384.363
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.makingcosmetics.com/Red-No-6-DC-Lake_p_229.html | https://www.law.cornell.edu/cfr/text/21/74.1306 | https://www.drugs.com/inactive/d-c-red-no-6-lake-352.html | https://www.makingcosmetics.com/Red-No-6-DC-Lake_p_229.html

D&C Red No. 6 is an excipient (pharmacologically inactive substance). It is FDA-approved, high-purity pigment. It can be tinted with titanium dioxide to create light red/pink shades. The color additive D&C Red No. 6 is principally the disodium salt of 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-2-naphthalenecarboxylic acid. To manufacture the additive, 2-amino-5-methylbenzenesulfonic acid is diazotized with hydrochloric acid and sodium nitrite. The diazo compound is coupled in alkaline medium with 3-hydroxy-2-naphthalenecarboxylic acid. The resulting dye precipitates as the disodium salt. D&C Red No. 6 is used in decorative cosmetic products including lipsticks, nail lacquers & face makeup (in USA prohibited for eye makeup), personal care products, soaps.

Approval Year

Sample Use Guides

In Vivo Use Guide

The color additive D&C Red No. 6 may be safely used for coloring drugs such that the combined total of D&C Red No. 6 and D&C Red No. 7 does not exceed 5 milligrams per daily dose of the drug.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:43:29 UTC 2023` Edited by `admin` on `Fri Dec 15 15:43:29 UTC 2023`
Record UNII	481744AI4O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

D&C RED NO. 6

Common Name

English

C.I. 15850

Common Name

English

LITHOL RUBIN B

Common Name

English

DC RED NO. 6

Common Name

English

AKA201 [INCI]

Common Name

English

PIGMENT RED 57, DISODIUM SALT

Common Name

English

2-NAPHTHALENECARBOXYLIC ACID, 3-HYDROXY-4-(2-(4-METHYL-2-SULFOPHENYL)DIAZENYL)-, SODIUM SALT (1:2)

Systematic Name

English

PIGMENT RED 57 [INCI]

Common Name

English

CI 15850 [INCI]

Common Name

English

RED 6

Official Name

English

D&C RED NO. 6 [II]

Common Name

English

CI 15850

Official Name

English

DISODIUM 3-HYDROXY-4-((E)-(4-METHYL-2-SULFONATOPHENYL)DIAZENYL)-2-NAPHTHOATE

Systematic Name

English

PIGMENT RED 57

Official Name

English

DISODIUM SALT OF 3-HYDROXY-4-((4-METHYL-2-SULFOPHENYL)AZO)-2-NAPHTHALENECARBOXYLIC ACID

Common Name

English

RED 6 [INCI]

Common Name

English

AKA201

Official Name

English

2-NAPHTHALENECARBOXYLIC ACID, 3-HYDROXY-4-((E)-(4-METHYL-2-SULFOPHENYL)AZO)-, DISODIUM SALT

Common Name

English

FD&C RED NO. 6 (DELISTED)

Common Name

English

DYE DC RED NO. 6

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C461