PHTHALAZINONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H6N2O
Molecular Weight	146.146
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1NN=CC2=C1C=CC=C2

InChI

InChIKey=IJAPPYDYQCXOEF-UHFFFAOYSA-N

InChI=1S/C8H6N2O/c11-8-7-4-2-1-3-6(7)5-9-10-8/h1-5H,(H,10,11)

HIDE SMILES / InChI

Molecular Formula	C8H6N2O
Molecular Weight	146.146
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Modifying a proton conductive membrane by embedding a "barrier".	2010-10-21	20873845
Azelastine hydrochloride, a dual-acting anti-inflammatory ophthalmic solution, for treatment of allergic conjunctivitis.	2010-09-07	20856595
Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors.	2009-10-01	19744860
Regioselective synthesis of N-aminoisoindolones and mono-N- and di-N,N'-substituted phthalazones utilizing hydrazine nucleophiles in a palladium-catalyzed three-component cascade process.	2008-11-07	18844421
Azelastine hydrochloride: a review of pharmacology, pharmacokinetics, clinical efficacy and tolerability.	2007-10	17723160
Design and syntheses of novel phthalazin-1(2H)-one derivatives as acetohydroxyacid synthase inhibitors.	2006-11-29	17117801
Microwave-assisted cyclic amidine synthesis using TiCl4.	2006-08-21	16886083
Anti-HIV activity of stilbene-related heterocyclic compounds.	2006-08-01	16713260
Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales).	2006-06-08	16737291
Synthesis and molluscicidal activity of some 1,3,4-triaryl-5-chloropyrazole, pyrano[2,3-c]pyrazole, pyrazolylphthalazine and pyrano[2,3-d]thiazole derivatives.	2006-06	16649159
Vasorelaxant activity of phthalazinones and related compounds.	2006-05-15	16513345
Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase.	2006-02-15	16290932
Some pyrrole substituted aryl pyridazinone and phthalazinone derivatives and their antihypertensive activities.	2004-12	15571871
Some pyridazinone and phthalazinone derivatives and their vasodilator activities.	2004-01	14969331
Human liver aldehyde oxidase: inhibition by 239 drugs.	2004-01	14681337
Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin.	2004	15625566
Synthesis and structural characterization of 1-(D-glycosyloxy)phthalazines.	2003-10-31	14572713
Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones.	2002-06-06	12036361
Novel phthalazinone and benzoxazinone containing thiazolidinediones as antidiabetic and hypolipidemic agents.	2001-10-16	11600232
Novel selective PDE4 inhibitors. 1. Synthesis, structure-activity relationships, and molecular modeling of 4-(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones and analogues.	2001-08-02	11472205

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:51:09 GMT 2025` Edited by `admin` on `Mon Mar 31 20:51:09 GMT 2025`
Record UNII	463ZJB0EI2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHTHALAZINONE

Systematic Name

English

NSC-10432

Preferred Name

English

1(2H)-PHTHALAZINONE

Systematic Name

English

1-HYDROXYPHTHALAZINE

Systematic Name

English

1-OXOPHTHALAZINE

Systematic Name

English

1-PHTHALAZINONE [USP IMPURITY]

Common Name

English

NSC-52567

Code

English

PHTHALAZIN-1-ONE

Systematic Name

English

1-PHTHALAZINOL

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

204-319-8