PHTHALAZINONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H6N2O
Molecular Weight	146.146
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1NN=CC2=C1C=CC=C2

InChI

InChIKey=IJAPPYDYQCXOEF-UHFFFAOYSA-N

InChI=1S/C8H6N2O/c11-8-7-4-2-1-3-6(7)5-9-10-8/h1-5H,(H,10,11)

HIDE SMILES / InChI

Molecular Formula	C8H6N2O
Molecular Weight	146.146
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Novel selective PDE4 inhibitors. 1. Synthesis, structure-activity relationships, and molecular modeling of 4-(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones and analogues.	2001 Aug 2	11472205
Novel phthalazinone and benzoxazinone containing thiazolidinediones as antidiabetic and hypolipidemic agents.	2001 Jul-Aug	11600232
Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones.	2002 Jun 6	12036361
Synthesis and structural characterization of 1-(D-glycosyloxy)phthalazines.	2003 Oct 31	14572713
Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin.	2004	15625566
Some pyrrole substituted aryl pyridazinone and phthalazinone derivatives and their antihypertensive activities.	2004 Dec	15571871
Some pyridazinone and phthalazinone derivatives and their vasodilator activities.	2004 Jan	14969331
Human liver aldehyde oxidase: inhibition by 239 drugs.	2004 Jan	14681337
Anti-HIV activity of stilbene-related heterocyclic compounds.	2006 Aug 1	16713260
Microwave-assisted cyclic amidine synthesis using TiCl4.	2006 Aug 21	16886083
Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase.	2006 Feb 15	16290932
Synthesis and molluscicidal activity of some 1,3,4-triaryl-5-chloropyrazole, pyrano[2,3-c]pyrazole, pyrazolylphthalazine and pyrano[2,3-d]thiazole derivatives.	2006 Jun	16649159
Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales).	2006 Jun 8	16737291
Vasorelaxant activity of phthalazinones and related compounds.	2006 May 15	16513345
Design and syntheses of novel phthalazin-1(2H)-one derivatives as acetohydroxyacid synthase inhibitors.	2006 Nov 29	17117801
Azelastine hydrochloride: a review of pharmacology, pharmacokinetics, clinical efficacy and tolerability.	2007 Oct	17723160
Regioselective synthesis of N-aminoisoindolones and mono-N- and di-N,N'-substituted phthalazones utilizing hydrazine nucleophiles in a palladium-catalyzed three-component cascade process.	2008 Nov 7	18844421
Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors.	2009 Oct 1	19744860
Modifying a proton conductive membrane by embedding a "barrier".	2010 Oct 21	20873845
Azelastine hydrochloride, a dual-acting anti-inflammatory ophthalmic solution, for treatment of allergic conjunctivitis.	2010 Sep 7	20856595

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:27:23 GMT 2023` Edited by `admin` on `Sat Dec 16 01:27:23 GMT 2023`
Record UNII	463ZJB0EI2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHTHALAZINONE

Systematic Name

English

1(2H)-PHTHALAZINONE

Systematic Name

English

1-HYDROXYPHTHALAZINE

Systematic Name

English

1-OXOPHTHALAZINE

Systematic Name

English

NSC-10432

Code

English

1-PHTHALAZINONE [USP IMPURITY]

Common Name

English

NSC-52567

Code

English

PHTHALAZIN-1-ONE

Systematic Name

English

1-PHTHALAZINOL

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

204-319-8