U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 18:35:25 GMT 2023
Edited
by admin
on Sat Dec 16 18:35:25 GMT 2023
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family Parvoviridae
Organism Genus Dependoparvovirus
Organism Species adeno-associated dependoparvovirus a
Infraspecific Type SEROTYPE
Infraspecific Name scAAV8-​pRLBP1-​hRLBP1
Part whole
Record UNII
45V2TAF3KB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SIRELRETIGENE SUBOPARVOVEC
INN  
Official Name English
A RECOMBINANT NON-REPLICATING SELF-COMPLEMENTARY ADENO-ASSOCIATED VIRUS SEROTYPE 8 (SCAAV8) VECTOR, ENCODING HUMAN CELLULAR RETINALDEHYDE-BINDING PROTEIN 1 (RLBP1) UNDER THE CONTROL OF THE RETINALDEHYDE-BINDING PROTEIN 1 PROMOTER (PRLBP1) AND SV40 POLY A
Common Name English
DNA (SELF-COMPLEMENTARY ADENO-ASSOCIATED VIRUS 8 VECTOR SCAAV-PRLBP1-HRLBP1 HUMAN GENE RLBP1 PROMOTER PLUS HUMAN RETINALDEHYDE-BINDING PROTEIN RLBP1-SPECIFYING)
Common Name English
A NON-REPLICATING SELF-COMPLEMENTARY ADENO-ASSOCIATED VIRUS SEROTYPE 8 (SCAAV8) VECTOR, ENCODING HUMAN CELLULAR RETINALDEHYDE-BINDING PROTEIN 1 (RLBP1)
Common Name English
sirelretigene suboparvovec [INN]
Common Name English
Code System Code Type Description
FDA UNII
45V2TAF3KB
Created by admin on Sat Dec 16 18:35:25 GMT 2023 , Edited by admin on Sat Dec 16 18:35:25 GMT 2023
PRIMARY
INN
11554
Created by admin on Sat Dec 16 18:35:25 GMT 2023 , Edited by admin on Sat Dec 16 18:35:25 GMT 2023
PRIMARY INN
CAS
2395524-75-9
Created by admin on Sat Dec 16 18:35:25 GMT 2023 , Edited by admin on Sat Dec 16 18:35:25 GMT 2023
PRIMARY
NCI_THESAURUS
C179122
Created by admin on Sat Dec 16 18:35:25 GMT 2023 , Edited by admin on Sat Dec 16 18:35:25 GMT 2023
PRIMARY
Related Record Type Details
EXPRESSED PROTEIN->VECTOR
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
TRANSGENE SIRELRETIGENE SUBOPARVOVEC TRANSGENE INSERT CW5FS6F5GQ