DEXAMETHASONE 9,11-EPOXIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H28O5
Molecular Weight	372.4547
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@@H]3O[C@]34[C@@]2([H])CCC5=CC(=O)C=C[C@]45C

InChI

InChIKey=GBDXNHBVYAMODG-QDBZYVRYSA-N

InChI=1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)22(15)18(27-22)10-20(16,3)21(12,26)17(25)11-23/h6-7,9,12,15-16,18,23,26H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19+,20+,21+,22-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H28O5
Molecular Weight	372.4547
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.clearsynth.com/en/CST52335.html | https://www.ncbi.nlm.nih.gov/pubmed/15212303 | https://www.drugs.com/pro/dexamethasone.html

Dexamethasone 9, 11-epoxide is an impurity in the commercial preparation of dexamethasone. Dexamethasone is an anti-inflammatory compound approved by the FDA for several conditions, including arthritis, skin diseases, croup, brain swelling, and others.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:58:04 UTC 2023` Edited by `admin` on `Fri Dec 15 15:58:04 UTC 2023`
Record UNII	45O198JS6W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEXAMETHASONE 9,11-EPOXIDE

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 9,11-EPOXY-17,21-DIHYDROXY-16-METHYL-, (9.BETA.,11.BETA.,16.ALPHA.)-

Systematic Name

English

8DM

Code

English

DEXAMETHASONE IMPURITY D [EP IMPURITY]

Common Name

English

MOMETASONE FUROATE IMPURITY L [EP IMPURITY]

Common Name

English

9.BETA.-PREGNA-1,4-DIENE-3,20-DIONE, 9,11.BETA.-EPOXY-17,21-DIHYDROXY-16.ALPHA.-METHYL-

Systematic Name

English

9.BETA.,11.BETA.-EPOXY-17,21-DIHYDROXY-16.ALPHA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID10862499