Maplirpacept

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 00:59:50 GMT 2025` Edited by `admin` on `Wed Apr 02 00:59:50 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type	IGG4
Sequence Type	COMPLETE
Record UNII	44D51T6SZH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TTI-622

Preferred Name

English

Maplirpacept

Official Name

English

1-118-Signal regulatory protein ? (human) fusion protein with immunoglobulin G4 [128-proline] (human ?4-chain C region C-terminal fragment), dimer

Common Name

English

Maplirpacept [WHO-DD]

Common Name

English

maplirpacept [INN]

Common Name

English

MAPLIRPACEPT [USAN]

Common Name

English

human signal-regulatory protein alpha (SIRP?, tyrosine-protein phosphatase non-receptor type substrate 1, inhibitory receptor SHPS-1), natural [L<sup>14</sup>>S, T<sup>20</sup>>S, T<sup>22</sup>>I, R<sup>24</sup>>H, A<sup>27</sup>>V, G<sup></sup>45>A, D<

Common Name

English

SIRP?-IgG4 F

Code

English

TTI622

Code

English

SIRPA-IGG4-FC FUSION PROTEIN TTI-622

Common Name

English

PF-07901801

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

858521

Created by admin on Wed Apr 02 00:59:50 GMT 2025 , Edited by admin on Wed Apr 02 00:59:50 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C150756

Created by admin on Wed Apr 02 00:59:50 GMT 2025 , Edited by admin on Wed Apr 02 00:59:50 GMT 2025

PRIMARY

NCIT

FDA UNII

44D51T6SZH

Created by admin on Wed Apr 02 00:59:50 GMT 2025 , Edited by admin on Wed Apr 02 00:59:50 GMT 2025

PRIMARY

USAN

LM-237

Created by admin on Wed Apr 02 00:59:50 GMT 2025 , Edited by admin on Wed Apr 02 00:59:50 GMT 2025

PRIMARY

CAS

2631667-06-4

Created by admin on Wed Apr 02 00:59:50 GMT 2025 , Edited by admin on Wed Apr 02 00:59:50 GMT 2025

PRIMARY

SMS_ID

300000024356

Created by admin on Wed Apr 02 00:59:50 GMT 2025 , Edited by admin on Wed Apr 02 00:59:50 GMT 2025

PRIMARY

INN

12295

Created by admin on Wed Apr 02 00:59:50 GMT 2025 , Edited by admin on Wed Apr 02 00:59:50 GMT 2025

PRIMARY

From	To
1_25	1_91
1_126	2_126
1_129	2_129
1_161	1_221
1_267	1_325
2_25	2_91
2_161	2_221
2_267	2_325

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_80
N	1_197
N	2_80
N	2_197

Related Record Type Details


					90DHW5TM9S

LEUKOCYTE SURFACE ANTIGEN CD47

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					44D51T6SZH

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_347] [2_347]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL