Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H6Cl4 |
| Molecular Weight | 291.988 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=C(C(Cl)=C1)C2=CC=C(Cl)C=C2Cl
InChI
InChIKey=QORAVNMWUNPXAO-UHFFFAOYSA-N
InChI=1S/C12H6Cl4/c13-7-1-3-9(11(15)5-7)10-4-2-8(14)6-12(10)16/h1-6H
| Molecular Formula | C12H6Cl4 |
| Molecular Weight | 291.988 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. | 2015-04-01 |
|
| Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO₂-PCBs. | 2011-10-10 |
|
| Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines. | 2011-04 |
|
| PCB-47, PBDE-47, and 6-OH-PBDE-47 differentially modulate human GABAA and alpha4beta2 nicotinic acetylcholine receptors. | 2010-12 |
|
| Activation and potentiation of human GABAA receptors by non-dioxin-like PCBs depends on chlorination pattern. | 2010-11 |
|
| Changes in mitogen-activated protein kinase in cerebellar granule neurons by polybrominated diphenyl ethers and polychlorinated biphenyls. | 2010-05-15 |
|
| Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells. | 2009-12-10 |
|
| Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro. | 2008-06 |
|
| Non-dioxin-like polychlorinated biphenyls induce a release of arachidonic acid in liver epithelial cells: a partial role of cytosolic phospholipase A(2) and extracellular signal-regulated kinases 1/2 signalling. | 2008-05-02 |
|
| Differential inhibition of hepatic microsomal alkoxyresorufin O-dealkylation activities by tetrachlorobiphenyls. | 2007-08-15 |
|
| 2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB. | 2007-06-15 |
|
| Kinetic and mechanistic study of photodechlorination of 2,2',4,4'-tetrachlorobiphenyl in surfactant solutions. | 2007-02 |
|
| In silico prediction of pregnane X receptor activators by machine learning approaches. | 2007-01 |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006-11 |
|
| The effect of chlorine substitution on the disposition of polychlorinated biphenyls following dermal administration. | 2006-10-01 |
|
| Chronic toxicity of 2,4,2',4'-tetrabromodiphenyl ether on the marine alga Skeletonema costatum and the crustacean Daphnia magna. | 2006-06 |
|
| Coplanar PCB congeners increase uterine weight and frontal cortical dopamine in the developing rat: implications for developmental neurotoxicity. | 2005-07 |
|
| Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2. | 2005-04 |
|
| Influence of a combination of two tetrachlorobiphenyl congeners (PCB 47; PCB 77) on thyroid status, choline acetyltransferase (ChAT) activity, and short- and long-term memory in 30-day-old Sprague-Dawley rats. | 2004-10-15 |
|
| Ortho-substituted but not coplanar PCBs rapidly kill cerebellar granule cells. | 2004-05 |
|
| Spectral interactions of tetrachlorobiphenyls with hepatic microsomal cytochrome p450 enzymes. | 2003-12-15 |
|
| Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. | 2003-10 |
|
| Influence of aeration on hydrophobic organic contaminant distribution and diffusive flux in estuarine sediments. | 2003-08-15 |
|
| Effects of PCB congeners on the immune function of Mytilus hemocytes: alterations of tyrosine kinase-mediated cell signaling. | 2003-05-08 |
|
| Developmental exposure to polychlorinated biphenyls affects sexual behavior of rats. | 2002-04-15 |
|
| Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. | 2001-03 |
|
| Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element. | 1998-12 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:58:30 GMT 2025
by
admin
on
Mon Mar 31 18:58:30 GMT 2025
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| Record UNII |
4470AQR07D
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| Record Status |
Validated (UNII)
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| Record Version |
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17097
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34204
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219-444-3
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4470AQR07D
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DTXSID0022513
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