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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 20:03:21 GMT 2025
Edited
by admin
on Tue Apr 01 20:03:21 GMT 2025
Protein Type RECEPTOR
Protein Sub Type NMDA|NMDA RECEPTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
43Q7J075IH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLUN2B
Preferred Name English
GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B
Common Name English
N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT 3
Common Name English
GLUTAMATE (NMDA) RECEPTOR SUBUNIT EPSILON-2
Common Name English
HNR3
Common Name English
NR3
Common Name English
NMDAR2B
Common Name English
NR2B
Common Name English
N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2B
Common Name English
Code System Code Type Description
PHAROS
Q13224
Created by admin on Tue Apr 01 20:03:21 GMT 2025 , Edited by admin on Tue Apr 01 20:03:21 GMT 2025
PRIMARY
FDA UNII
43Q7J075IH
Created by admin on Tue Apr 01 20:03:21 GMT 2025 , Edited by admin on Tue Apr 01 20:03:21 GMT 2025
PRIMARY
WIKIPEDIA
GRIN2B
Created by admin on Tue Apr 01 20:03:21 GMT 2025 , Edited by admin on Tue Apr 01 20:03:21 GMT 2025
PRIMARY
UNIPROT
Q13224
Created by admin on Tue Apr 01 20:03:21 GMT 2025 , Edited by admin on Tue Apr 01 20:03:21 GMT 2025
PRIMARY
From To
1_60 1_295
1_403 1_430
1_410 1_431
1_720 1_775
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_48
N 1_315
N 1_322
N 1_418
N 1_465
N 1_516
N 1_662
Related Record Type Details
Structure of PEAQX
INHIBITOR -> TARGET
the Ki of PEAQX revealed it only shows a 5 fold difference in affinity for GluN1/GluN2A vs. GluN1/GluN2B receptors. It is also a potent anticonvulsant in animal tests.
COMPETITIVE ANTAGONIST
Structure of NP-10679
INHIBITOR -> TARGET
Potent and selective GluN2B subunit-specific NMDA (N-methyl-D-aspartate) receptor inhibitor.
Structure of RISLENEMDAZ
INHIBITOR -> TARGET
Structure of TAURINE
INHIBITOR -> TARGET
Structure of TRAXOPRODIL
INHIBITOR -> TARGET
Structure of PLAZINEMDOR
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Structure of WMS-1405
INHIBITOR -> TARGET
Ki
Structure of (2S)-4-[[5-(2-Fluoro-4-methylphenoxy)-2-pyrazinyl]methyl]-N-methyl-2-morpholinecarboxamide
INHIBITOR -> TARGET
Structure of Onfasprodil
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
ALLOSTERIC INHIBITOR
IC50
Structure of RADIPRODIL
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
Structure of WMS-1405 C-11
RADIOLIGAND->TARGET
Ki

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_856] [1_860] [1_891] [1_894] [1_1032] [1_1035] [1_1038] [1_1117] [1_1229] [1_1233] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
NCATS
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