PNU-37783A

Details

Stereochemistry	MIXED
Molecular Formula	C21H35N3O
Molecular Weight	345.5221
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1CCC(CC1)NC(=NC23CC4CC(CC(C4)C2)C3)N5CCOCC5

InChI

InChIKey=GKCGWXNLOYTUNC-UHFFFAOYSA-N

InChI=1S/C21H35N3O/c1-2-4-19(5-3-1)22-20(24-6-8-25-9-7-24)23-21-13-16-10-17(14-21)12-18(11-16)15-21/h16-19H,1-15H2,(H,22,23)

HIDE SMILES / InChI

Molecular Formula	C21H35N3O
Molecular Weight	345.5221
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Potassium channel, inwardly rectifying, subfamily J, member 8 1 Target ID: CHEMBL4770 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14757705\|https://www.ncbi.nlm.nih.gov/pubmed/10516647	Blocker 555		32.0 µM [IC50]
ATP-sensitive potassium channel complex 1 Target ID: GO:0008282 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9750009\|https://www.ncbi.nlm.nih.gov/pubmed/8058048\|https://www.ncbi.nlm.nih.gov/pubmed/8229751	Blocker 555		0.78 µM [IC50]

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:53:01 GMT 2025` Edited by `admin` on `Mon Mar 31 22:53:01 GMT 2025`
Record UNII	43NV3J455P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

U-37883

Preferred Name

English

PNU-37783A

Code

English

4-Morpholinecarboximidamide, N-cyclohexyl-N?-tricyclo[3.3.1.13,7]dec-1-yl-

Systematic Name

English

Code System Code Type Description

FDA UNII

43NV3J455P

Created by admin on Mon Mar 31 22:53:01 GMT 2025 , Edited by admin on Mon Mar 31 22:53:01 GMT 2025

PRIMARY

EPA CompTox

DTXSID80206200

Created by admin on Mon Mar 31 22:53:01 GMT 2025 , Edited by admin on Mon Mar 31 22:53:01 GMT 2025

PRIMARY

PUBCHEM

64392

Created by admin on Mon Mar 31 22:53:01 GMT 2025 , Edited by admin on Mon Mar 31 22:53:01 GMT 2025

PRIMARY

CAS

57568-80-6

Created by admin on Mon Mar 31 22:53:01 GMT 2025 , Edited by admin on Mon Mar 31 22:53:01 GMT 2025

PRIMARY

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Adenosine 5?-triphosphate-sensitive potassium ion (KATP) channel Kir6.1/Sur 2B

TARGET -> INHIBITOR

Comments:

Selective for Kir6.1/Sur2b potassium channel

Qualification:

IC50

Amount:

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					43NV3J455P

PNU-37783A

ACTIVE MOIETY

Comments:

PNU37783A was stopped in clinical development.

Amount: