ENAPOTAMAB VEDOTIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:13:39 GMT 2025` Edited by `admin` on `Tue Apr 01 22:13:39 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|TOXIN CONJUGATE\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	43HH4XYH2N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ENAPOTAMAB VEDOTIN

Official Name

English

AXL-107-MMAE

Preferred Name

English

HUMAXAXLADC

Code

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN GROWTH FACTOR RECEPTOR AXL)(HUMAN HUMAX-AXL GAMMA LIGHT CHAIN), DISULFIDE WITH HUMAN HUMAX-AXL KAPPA CHAIN, DIMER, MONOMETHYL AURISTATIN E CONJUGATE

Common Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN GROWTH FACTOR RECEPTOR AXL)(HUMAN HUMAX-AXL .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN HUMAX-AXL .KAPPA.-CHAIN, DIMER TETRAKIS(THIOETHER) WITH VEDOTIN

Common Name

English

enapotamab vedotin [INN]

Common Name

English

HUMAX-AXL-ADC

Code

English

Enapotamab vedotin [WHO-DD]

Common Name

English

Code System Code Type Description

INN

10769

Created by admin on Tue Apr 01 22:13:39 GMT 2025 , Edited by admin on Tue Apr 01 22:13:39 GMT 2025

PRIMARY

NCI_THESAURUS

C132017

Created by admin on Tue Apr 01 22:13:39 GMT 2025 , Edited by admin on Tue Apr 01 22:13:39 GMT 2025

PRIMARY

SMS_ID

100000181700

Created by admin on Tue Apr 01 22:13:39 GMT 2025 , Edited by admin on Tue Apr 01 22:13:39 GMT 2025

PRIMARY

CAS

1912424-97-5

Created by admin on Tue Apr 01 22:13:39 GMT 2025 , Edited by admin on Tue Apr 01 22:13:39 GMT 2025

PRIMARY

FDA UNII

43HH4XYH2N

Created by admin on Tue Apr 01 22:13:39 GMT 2025 , Edited by admin on Tue Apr 01 22:13:39 GMT 2025

PRIMARY

From	To
1_22	1_96
1_143	1_199
1_260	1_320
1_366	1_424
2_22	2_96
2_143	2_199
2_260	2_320
2_366	2_424
1_219	3_215
1_225	2_225
1_228	2_228
2_219	4_215
3_23	3_89
3_135	3_195
4_23	4_89
4_135	4_195

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					FFX71LCS5T

CONJUGATE COMPONENT->CONJUGATE

Amount:


					8EJE45ZR0I

TYROSINE-PROTEIN KINASE RECEPTOR UFO

TARGET->CONJUGATED TOXIN

Amount:


					Q3606FDE0B

VEDOTIN FRAGMENT

CONJUGATE COMPONENT->CONJUGATE

Amount:

Related Record Type Details


					43HH4XYH2N

ENAPOTAMAB VEDOTIN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	C	Amount:	Cysteinyl vedotin	6603L01WUR

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL