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Details

Stereochemistry ACHIRAL
Molecular Formula Mn
Molecular Weight 54.938
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MANGANESE

SMILES

[Mn]

InChI

InChIKey=PWHULOQIROXLJO-UHFFFAOYSA-N
InChI=1S/Mn

HIDE SMILES / InChI

Molecular Formula Mn
Molecular Weight 54.938
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
[Environmental factors in western Pacific foci of ALS and a possible pathogenetic role of aluminum (Al) in motor neuron degeneration].
1991 Dec
Manganese oxidation state mediates toxicity in PC12 cells.
2005 Jun 15
NF-kappaB-dependent production of nitric oxide by astrocytes mediates apoptosis in differentiated PC12 neurons following exposure to manganese and cytokines.
2005 Nov 18
Early environmental origins of neurodegenerative disease in later life.
2005 Sep
Hydrogen peroxide cleavage of the prion protein generates a fragment able to initiate polymerisation of full length prion protein.
2006
A manganese-enhanced diet alters brain metals and transporters in the developing rat.
2006 Aug
Cytogenetic effects of a mixture of selected metals following subchronic exposure through drinking water in male rats.
2006 Dec
Activation of MAP kinases by hexavalent chromium, manganese and nickel in human lung epithelial cells.
2006 Dec 1
Water manganese exposure and children's intellectual function in Araihazar, Bangladesh.
2006 Jan
ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties.
2006 Jul
SOD2-deficiency sideroblastic anemia and red blood cell oxidative stress.
2006 Jul-Aug
Lactoferrin and bone; structure-activity relationships.
2006 Jun
Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes.
2006 Jun 15
Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro.
2006 Jun 30
Uncompetitive inhibition of Xenopus laevis aldehyde dehydrogenase 1A1 by divalent cations.
2006 Mar
Manganese antagonizes iron blocking mitochondrial aconitase expression in human prostate carcinoma cells.
2006 May
N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen.
2006 May
Decreased expression of inflammation-related genes following inhalation exposure to manganese.
2006 May
Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells.
2006 May 1
TAK1-binding protein 1 is a pseudophosphatase.
2006 Nov 1
Signaling pathways mediating manganese-induced toxicity in human glioblastoma cells (u87).
2006 Oct
The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.
2006 Oct
Divalent-metal-dependent nucleolytic activity of Cu, Zn superoxide dismutase.
2006 Oct
Manganese suppresses ATP-dependent intercellular calcium waves in astrocyte networks through alteration of mitochondrial and endoplasmic reticulum calcium dynamics.
2006 Oct 3
Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain.
2006 Sep
Copper(II) and manganese(III) complexes of N'-[(2-hydroxy phenyl) carbonothioyl] pyridine-2-carbohydrazide: novel therapeutic agents for cancer.
2006 Sep
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.
2006 Summer
Putative proteins involved in manganese transport across the blood-brain barrier.
2007 Apr
KATP channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart.
2007 Apr
Ovotransferrin possesses SOD-like superoxide anion scavenging activity that is promoted by copper and manganese binding.
2007 Dec 1
Induction of metallothionein by manganese is completely dependent on interleukin-6 production.
2007 Feb
Olfactory uptake of manganese requires DMT1 and is enhanced by anemia.
2007 Jan
Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain.
2007 Jan
Manganese induces oxidative impairment in cultured rat astrocytes.
2007 Jul
The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats: comparison with the toxic effect on NAD(P)H:quinone reductase.
2007 Jul 31
Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells.
2007 Jun
Subchronic inhalation of soluble manganese induces expression of hypoxia-associated angiogenic genes in adult mouse lungs.
2007 Jun 1
Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells.
2007 May
Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects.
2007 Nov
Role of Ca2+-independent phospholipase A2 and store-operated pathway in urocortin-induced vasodilatation of rat coronary artery.
2007 Nov 26
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.
2007 Sep
Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus.
2007 Sep
Inhibition of lipopolysaccharide activation of Kupffer cells by transition metals.
2008 Aug
Mitochondrial-mediated apoptosis in neural stem cells exposed to manganese.
2008 Feb
The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells.
2008 Feb 15
The role of dopamine transporter in selective toxicity of manganese and rotenone.
2008 Feb 28
Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways.
2008 Jul
Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.
2008 Mar-Apr
Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging.
2008 May
Manganese cell labeling of murine hepatocytes using manganese(III)-transferrin.
2008 May-Jun
Patents

Patents

Substance Class Chemical
Created
by admin
on Wed Jul 05 23:07:31 UTC 2023
Edited
by admin
on Wed Jul 05 23:07:31 UTC 2023
Record UNII
42Z2K6ZL8P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MANGANESE
HSDB   MART.   MI   VANDF   WHO-DD  
Systematic Name English
MN
Common Name English
MANGANESE [VANDF]
Common Name English
MANGANUM METALLICUM
HPUS  
Common Name English
MANGANESE [HSDB]
Common Name English
MANGANESE [MI]
Common Name English
Manganese [WHO-DD]
Common Name English
MANGANESE [MART.]
Common Name English
MANGANUM METALLICUM [HPUS]
Common Name English
Classification Tree Code System Code
LIVERTOX 580
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
NCI_THESAURUS C637
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
NCI_THESAURUS C896
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
DSLD 252 (Number of products:6106)
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
Code System Code Type Description
EVMPD
SUB14477MIG
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
ALTERNATIVE
CAS
7439-96-5
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
WIKIPEDIA
Manganese
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
MESH
D008345
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
SMS_ID
100000091504
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
DRUG BANK
DB06757
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
RXCUI
6623
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY RxNorm
DAILYMED
42Z2K6ZL8P
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
CHEBI
18291
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
ECHA (EC/EINECS)
231-105-1
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
FDA UNII
42Z2K6ZL8P
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
HSDB
550
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
EVMPD
SUB14466MIG
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
NCI_THESAURUS
C68266
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
PUBCHEM
23930
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
CHEBI
35154
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
MERCK INDEX
M7058
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID2024169
Created by admin on Wed Jul 05 23:07:31 UTC 2023 , Edited by admin on Wed Jul 05 23:07:31 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
PARENT -> CONSTITUENT ALWAYS PRESENT
Nutritional value per 100 g (3.5 oz) - 0.21 mg (10%)
Related Record Type Details
ACTIVE MOIETY