MANGANESE

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Mn
Molecular Weight	54.938
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Mn]

InChI

InChIKey=PWHULOQIROXLJO-UHFFFAOYSA-N

InChI=1S/Mn

HIDE SMILES / InChI

Molecular Formula	Mn
Molecular Weight	54.938
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Elevated levels of ferrimagnetic metals in foodchains supporting the Guam cluster of neurodegeneration: do metal nucleated crystal contaminants [corrected] evoke magnetic fields that initiate the progressive pathogenesis of neurodegeneration?	2004	15488650
Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death.	2004 Dec	15681813
Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells.	2004 Sep 24	15342272
Structural studies of the biomineralized species of calcified pancreatic stones in patients suffering from chronic pancreatitis.	2005 Apr 22	15829347
Manganese oxidation state mediates toxicity in PC12 cells.	2005 Jun 15	15922012
NF-kappaB-dependent production of nitric oxide by astrocytes mediates apoptosis in differentiated PC12 neurons following exposure to manganese and cytokines.	2005 Nov 18	16168523
Early environmental origins of neurodegenerative disease in later life.	2005 Sep	16140633
Hydrogen peroxide cleavage of the prion protein generates a fragment able to initiate polymerisation of full length prion protein.	2006	16595185
A manganese-enhanced diet alters brain metals and transporters in the developing rat.	2006 Aug	16705042
The kinetics of inhibition of Vigna catjang cotyledon and buffalo liver arginase by L-proline and branched-chain amino acids.	2006 Dec	17252946
Environmental stressors (salinity, heavy metals, H2O2) modulate expression of glutathione reductase (GR) gene from the intertidal copepod Tigriopus japonicus.	2006 Dec 1	17079028
Water manganese exposure and children's intellectual function in Araihazar, Bangladesh.	2006 Jan	16393669
ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties.	2006 Jul	16638970
Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase.	2006 Jul 28	16737955
Temporal responses in the disruption of iron regulation by manganese.	2006 Jun	16568477
Manganese and iron transport across pulmonary epithelium.	2006 Jun	16428268
Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes.	2006 Jun 15	16386771
Evidence for a two-step mechanism involved in the formation of covalent HC x TSG-6 complexes.	2006 Jun 20	16768462
Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro.	2006 Jun 30	16729984
Uncompetitive inhibition of Xenopus laevis aldehyde dehydrogenase 1A1 by divalent cations.	2006 Mar	16603817
Manganese antagonizes iron blocking mitochondrial aconitase expression in human prostate carcinoma cells.	2006 May	16625280
N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen.	2006 May	16606368
Decreased expression of inflammation-related genes following inhalation exposure to manganese.	2006 May	16476481
Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells.	2006 May 1	16417967
Postnatal manganese exposure attenuates cocaine-induced locomotor activity and reduces dopamine transporters in adult male rats.	2006 May-Jun	16571372
Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure.	2006 Nov	16991145
The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.	2006 Oct	16860484
Manganese suppresses ATP-dependent intercellular calcium waves in astrocyte networks through alteration of mitochondrial and endoplasmic reticulum calcium dynamics.	2006 Oct 3	16934782
Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain.	2006 Sep	16842851
Brain accumulation and toxicity of Mn(II) and Mn(III) exposures.	2006 Sep	16740617
Copper(II) and manganese(III) complexes of N'-[(2-hydroxy phenyl) carbonothioyl] pyridine-2-carbohydrazide: novel therapeutic agents for cancer.	2006 Sep	16600465
Molecular mechanism of distorted iron regulation in the blood-CSF barrier and regional blood-brain barrier following in vivo subchronic manganese exposure.	2006 Sep	16545456
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.	2006 Summer	16943606
Putative proteins involved in manganese transport across the blood-brain barrier.	2007 Apr	17615110
KATP channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart.	2007 Apr	17189350
Ovotransferrin possesses SOD-like superoxide anion scavenging activity that is promoted by copper and manganese binding.	2007 Dec 1	17919719
Induction of metallothionein by manganese is completely dependent on interleukin-6 production.	2007 Feb	17065364
Amino acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system.	2007 Feb 15	16937399
Manganese induces oxidative impairment in cultured rat astrocytes.	2007 Jul	17468184
The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats: comparison with the toxic effect on NAD(P)H:quinone reductase.	2007 Jul 31	17573173
Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells.	2007 Jun	17469137
Subchronic inhalation of soluble manganese induces expression of hypoxia-associated angiogenic genes in adult mouse lungs.	2007 Jun 1	17467022
Effect of manganese supplementation and source on carcass traits, meat quality, and lipid oxidation in broilers.	2007 Mar	17040939
Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects.	2007 Nov	17662456
Role of Ca2+-independent phospholipase A2 and store-operated pathway in urocortin-induced vasodilatation of rat coronary artery.	2007 Nov 26	17885217
Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus.	2007 Sep	17827730
Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways.	2008 Jul	18335517
Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates.	2008 Jun	18284614
Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging.	2008 May	18234737
Manganese cell labeling of murine hepatocytes using manganese(III)-transferrin.	2008 May-Jun	18546093

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:38:18 GMT 2023` Edited by `admin` on `Fri Dec 15 15:38:18 GMT 2023`
Record UNII	42Z2K6ZL8P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MANGANESE

Systematic Name

English

MN

Common Name

English

MANGANESE [VANDF]

Common Name

English

MANGANUM METALLICUM

Common Name

English

MANGANESE [HSDB]

Common Name

English

MANGANESE [MI]

Common Name

English

Manganese [WHO-DD]

Common Name

English

MANGANESE [MART.]

Common Name

English

MANGANUM METALLICUM [HPUS]

Common Name

English

Classification Tree Code System Code

LIVERTOX

580