MANGANESE

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Mn
Molecular Weight	54.938045
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Mn]

InChI

InChIKey=PWHULOQIROXLJO-UHFFFAOYSA-N

InChI=1S/Mn

HIDE SMILES / InChI

Molecular Formula	Mn
Molecular Weight	54.938045
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Inhibition of lipopolysaccharide activation of Kupffer cells by transition metals.	2008-08	18547589
Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways.	2008-07	18335517
Manganese cell labeling of murine hepatocytes using manganese(III)-transferrin.	2008-06-12	18546093
Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates.	2008-06	18284614
Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging.	2008-05	18234737
The role of dopamine transporter in selective toxicity of manganese and rotenone.	2008-02-28	18206288
The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells.	2008-02-15	18041089
Mitochondrial-mediated apoptosis in neural stem cells exposed to manganese.	2008-02	17977900
Ovotransferrin possesses SOD-like superoxide anion scavenging activity that is promoted by copper and manganese binding.	2007-12-01	17919719
Role of Ca2+-independent phospholipase A2 and store-operated pathway in urocortin-induced vasodilatation of rat coronary artery.	2007-11-26	17885217
Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.	2007-11-08	18317567
Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects.	2007-11	17662456
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.	2007-09	17916923
Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus.	2007-09	17827730
The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats: comparison with the toxic effect on NAD(P)H:quinone reductase.	2007-07-31	17573173
Manganese induces oxidative impairment in cultured rat astrocytes.	2007-07	17468184
Subchronic inhalation of soluble manganese induces expression of hypoxia-associated angiogenic genes in adult mouse lungs.	2007-06-01	17467022
Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells.	2007-06	17469137
Induction of cyclooxygenase-2 expression by manganese in cultured astrocytes.	2007-06	17084486
Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells.	2007-05	17175027
Putative proteins involved in manganese transport across the blood-brain barrier.	2007-04	17615110
KATP channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart.	2007-04	17189350
Effect of manganese supplementation and source on carcass traits, meat quality, and lipid oxidation in broilers.	2007-03	17040939
Amino acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system.	2007-02-15	16937399
Induction of metallothionein by manganese is completely dependent on interleukin-6 production.	2007-02	17065364
Olfactory uptake of manganese requires DMT1 and is enhanced by anemia.	2007-01	17116743
Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain.	2007-01	17060373
Manganese is highly effective in protecting cells from cadmium intoxication.	2006-12-08	17055454
Environmental stressors (salinity, heavy metals, H2O2) modulate expression of glutathione reductase (GR) gene from the intertidal copepod Tigriopus japonicus.	2006-12-01	17079028
Activation of MAP kinases by hexavalent chromium, manganese and nickel in human lung epithelial cells.	2006-12-01	17045426
The kinetics of inhibition of Vigna catjang cotyledon and buffalo liver arginase by L-proline and branched-chain amino acids.	2006-12	17252946
Cytogenetic effects of a mixture of selected metals following subchronic exposure through drinking water in male rats.	2006-12	17176674
TAK1-binding protein 1 is a pseudophosphatase.	2006-11-01	16879102
Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure.	2006-11	16991145
Manganese suppresses ATP-dependent intercellular calcium waves in astrocyte networks through alteration of mitochondrial and endoplasmic reticulum calcium dynamics.	2006-10-03	16934782
Signaling pathways mediating manganese-induced toxicity in human glioblastoma cells (u87).	2006-10	17043766
Differential effect of nerve growth factor on dopaminergic neurotoxin-induced apoptosis.	2006-10	17029596
The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.	2006-10	16860484
Divalent-metal-dependent nucleolytic activity of Cu, Zn superoxide dismutase.	2006-10	16804677
Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain.	2006-09	16842851
Brain accumulation and toxicity of Mn(II) and Mn(III) exposures.	2006-09	16740617
SOD2-deficiency sideroblastic anemia and red blood cell oxidative stress.	2006-08-17	16910769
Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase.	2006-07-28	16737955
p44/42 MAP kinase and c-Jun N-terminal kinase contribute to the up-regulation of caspase-3 in manganese-induced apoptosis in PC12 cells.	2006-07-12	16787641
Structural insights into the mechanism of PEPCK catalysis.	2006-07-11	16819824
Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro.	2006-06-30	16729984
Evidence for a two-step mechanism involved in the formation of covalent HC x TSG-6 complexes.	2006-06-20	16768462
Lactoferrin and bone; structure-activity relationships.	2006-06	16936800
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.	2006	16943606
[Environmental factors in western Pacific foci of ALS and a possible pathogenetic role of aluminum (Al) in motor neuron degeneration].	1991-12	1817796

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:03:52 GMT 2025` Edited by `admin` on `Mon Mar 31 18:03:52 GMT 2025`
Record UNII	42Z2K6ZL8P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MANGANUM METALLICUM

Preferred Name

English

MANGANESE

Systematic Name

English

MN

Common Name

English

MANGANESE [VANDF]

Common Name

English

MANGANESE [HSDB]

Common Name

English

MANGANESE [MI]

Common Name

English

Manganese [WHO-DD]

Common Name

English

MANGANESE [MART.]

Common Name

English

MANGANUM METALLICUM [HPUS]

Common Name

English

Classification Tree Code System Code

LIVERTOX

580