TECHNETIUM TC-99M TETROFOSMIN

First approved in 1973

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H42O3P2.C18H40O4P2.O2Tc
Molecular Weight	893.8429
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TECHNETIUM TC-99M TETROFOSMIN

Structure Search

SMILES

O=[99Tc]=O.CCCCCP(CCOCC)CCP(CCOCC)CCOCC.CCOCCP(CCOCC)CCP(CCOCC)CCOCC

InChI

InChIKey=ZHNAJKOTNXMUGO-RCUQKECRSA-N

InChI=1S/C19H42O3P2.C18H40O4P2.2O.Tc/c1-5-9-10-14-23(15-11-20-6-2)18-19-24(16-12-21-7-3)17-13-22-8-4;1-5-19-9-13-23(14-10-20-6-2)17-18-24(15-11-21-7-3)16-12-22-8-4;;;/h5-19H2,1-4H3;5-18H2,1-4H3;;;/i;;;;1+1

HIDE SMILES / InChI

Molecular Formula	C19H42O3P2
Molecular Weight	380.4825
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C18H40O4P2
Molecular Weight	382.4553
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	O2Tc
Molecular Weight	130.9051
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.hindawi.com/journals/stni/2014/839369/
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/books/NBK215133/ | https://www.iaea.org/OurWork/ST/NE/NEFW/Technical-Areas/RRS/documents /mo99/WORKINGMATERIALSmo99CM.pdf | https://www.ncbi.nlm.nih.gov/pubmed/27854401

Molybdenum-99 (99Mo, half-life = 66 h) is a parent radionuclide of a diagnostic nuclear isotope. It decays in technetium-99 m (half-life = 6 h), which is used in over 30 million procedures per year around the world. Between 95 and 98 percent of Mo-99 is currently being produced using highly enriched uranium (HEU) targets. Other medical isotopes such as iodine-131 (I-131) and xenon-133 (Xe-133) are by-products of the Mo-99 production process and will be sufficiently available if Mo-99 is available.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
bone problems 43 Sources: https://www.drugs.com/cons/osteolite.html	Diagnostic	Approved 8429	OSTEOLITE Approved Use Unknown Launch Date 1977
osteogenesis 43 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018035s032lbl.pdf	Diagnostic	Approved 8429	DRAXIMAGE MDP-10 Approved Use MDP-25 (Kit for the Preparation of Technetium Tc 99m Medronate) may be used as a bone imaging agent to delineate areas of altered osteogenesis. Launch Date 1978

PubMed

Title	Date	PubMed
Future of low specific activity molybdenum-99/technetium-99m generator.	2012 Oct	22642420

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:36:04 GMT 2023` Edited by `admin` on `Fri Dec 15 17:36:04 GMT 2023`
Record UNII	42FOP1YX93
Record Status	`Validated (UNII)`
Record Version

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Related Record	Type

Name

Type

Language

TECHNETIUM TC-99M TETROFOSMIN

Common Name

English

TETROFOSMIN COMPLEX WITH 99MTC [MI]

Common Name

English

PPN-1011

Code

English

99MTC-TETROFOSMIN

Common Name

English

TECHNETIUM TC 99M TETROFOSMIN [USP IMPURITY]

Common Name

English

TECHNETIUM TC 99M 1,2-BIS(BIS(2-ETHOXYETHYL)PHOSPHINO)ETHANE

Common Name

English

Technetium tc 99m tetrofosmin [WHO-DD]

Common Name

English

MYOVIEW

Brand Name

English

TECHNETIUM(1+)-99TC, BIS(6,9-BIS(2-ETHOXYETHYL)-3,12-DIOXA-6,9-DIPHOSPHATETRADECANE-.KAPPA.P,.KAPPA.P')DIOXO-, (OC-6-11)-

Systematic Name

English

TECHNETIUM-99 TETROFOSMIN

Common Name

English

TECHNETIUM TC 99M TETROFOSMIN

Common Name

English

Classification Tree Code System Code

WHO-ATC

V09GA02