Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H23NS.ClH |
Molecular Weight | 285.876 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.C1CCN(CC1)C2(CCCCC2)C3=CC=CS3
InChI
InChIKey=IIPLEZRBGQCZMF-UHFFFAOYSA-N
InChI=1S/C15H23NS.ClH/c1-3-9-15(10-4-1,14-8-7-13-17-14)16-11-5-2-6-12-16;/h7-8,13H,1-6,9-12H2;1H
Molecular Formula | C15H23NS |
Molecular Weight | 249.415 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Tenocyclidine (TCP) is a dissociative anesthetic drug with psychostimulant and hallucinogenic effects. This drug shows a broad spectrum of pharmacological activity including antidotal effect in organophosphorus compounds poisoning, radioprotective and anticancer effects. It was studied that the antidotal potency could protect acetylcholinesterase (AChE) in the case of organophosphate poisoning. However, the controversial role of TCP in brain protection should be studied further. Tenocyclidine has a high affinity for the N-methyl-D-aspartate (NMDA) receptors. This property allows using of TCP binding (association rate) as a marker of channel opening and thereby permitting measurement of NMDA receptor activation and ligand binding under identical conditions.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Effects of thienylphencyclidine (TCP) on seizure activity and brain damage produced by soman in guinea-pigs: ECoG correlates of neurotoxicity. | 2001 Feb |
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Re-evaluation of phencyclidine low-affinity or "non-NMDA" binding sites. | 2002 May 1 |
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Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants. | 2003 Dec |
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Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure. | 2007 May 19 |
|
Tenocyclidine treatment in soman-poisoned rats--intriguing results on genotoxicity versus protection. | 2008 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:25:53 GMT 2023
by
admin
on
Fri Dec 15 16:25:53 GMT 2023
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Record UNII |
425WW340S2
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Record Status |
Validated (UNII)
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Record Version |
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425WW340S2
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DBSALT002317
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16640802
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1867-65-8
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DTXSID40904770
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ACTIVE MOIETY |