Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H23NS.ClH |
| Molecular Weight | 285.876 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.C1CCN(CC1)C2(CCCCC2)C3=CC=CS3
InChI
InChIKey=IIPLEZRBGQCZMF-UHFFFAOYSA-N
InChI=1S/C15H23NS.ClH/c1-3-9-15(10-4-1,14-8-7-13-17-14)16-11-5-2-6-12-16;/h7-8,13H,1-6,9-12H2;1H
| Molecular Formula | C15H23NS |
| Molecular Weight | 249.415 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Tenocyclidine (TCP) is a dissociative anesthetic drug with psychostimulant and hallucinogenic effects. This drug shows a broad spectrum of pharmacological activity including antidotal effect in organophosphorus compounds poisoning, radioprotective and anticancer effects. It was studied that the antidotal potency could protect acetylcholinesterase (AChE) in the case of organophosphate poisoning. However, the controversial role of TCP in brain protection should be studied further. Tenocyclidine has a high affinity for the N-methyl-D-aspartate (NMDA) receptors. This property allows using of TCP binding (association rate) as a marker of channel opening and thereby permitting measurement of NMDA receptor activation and ligand binding under identical conditions.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| 1,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action. | 2010-07 |
|
| Qualitative GC-MS assessment of TCP and TAMORF elimination in rats. | 2010-03 |
|
| Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency. | 2009-11 |
|
| High specific activity tritiation of TCP and BTCP. | 2009-06 |
|
| Engineering and characterization of a mouse/human chimeric anti-phencyclidine monoclonal antibody. | 2008-01 |
|
| Tenocyclidine treatment in soman-poisoned rats--intriguing results on genotoxicity versus protection. | 2008 |
|
| Molecular properties of local anesthetics as predictors of affinity for nicotinic acetylcholine receptors. | 2007-10 |
|
| Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure. | 2007-05-19 |
|
| Structure-activity relationships of pentacycloundecylamines at the N-methyl-d-aspartate receptor. | 2007-02-01 |
|
| In vitro biological efficiency of tenocyclidine-TCP and its adamantane derivative TAMORF. | 2006-12 |
|
| The role of antagonism of NMDA receptor-mediated neurotransmission and inhibition of the dopamine reuptake in the neuroendocrine effects of phencyclidine. | 2006-03-20 |
|
| Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors. | 2006-02-21 |
|
| Characterization of the non-competitive antagonist binding site of the NMDA receptor in dark Agouti rats. | 2004-08-06 |
|
| [An expert study of acute poisoning by phencyclidine derivatives]. | 2004-07-03 |
|
| Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants. | 2003-12 |
|
| Re-evaluation of phencyclidine low-affinity or "non-NMDA" binding sites. | 2002-05-01 |
|
| Decreased density of [3H]TCP binding following antipsychotic drug withdrawal in rats. | 2002-04-19 |
|
| Amphetamine inhibits the N-methyl-D-aspartate receptor-mediated responses by directly interacting with the receptor/channel complex. | 2002-03 |
|
| Beneficial effects of TCP on soman intoxication in guinea pigs: seizures, brain damage and learning behaviour. | 2001-12 |
|
| Effects of thienylphencyclidine (TCP) on seizure activity and brain damage produced by soman in guinea-pigs: ECoG correlates of neurotoxicity. | 2001-02 |
|
| Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine. | 1999-05 |
| Substance Class |
Chemical
Created
by
admin
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Edited
Mon Mar 31 18:27:44 GMT 2025
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| Record UNII |
425WW340S2
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| Record Status |
Validated (UNII)
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| Record Version |
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40903
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425WW340S2
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DBSALT002317
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16640802
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1867-65-8
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DTXSID40904770
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PARENT -> SALT/SOLVATE |
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