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Details

Stereochemistry ACHIRAL
Molecular Formula CO3.Sr
Molecular Weight 147.63
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of STRONTIUM CARBONATE

SMILES

[Sr++].[O-]C([O-])=O

InChI

InChIKey=LEDMRZGFZIAGGB-UHFFFAOYSA-L
InChI=1S/CH2O3.Sr/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2

HIDE SMILES / InChI

Molecular Formula Sr
Molecular Weight 87.62
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula CO3
Molecular Weight 60.0089
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Strontium ranelate is composed of an organic moiety (ranelic acid) and of two atoms of stable nonradioactive strontium. In vitro, strontium ranelate increases collagen and noncollagenic proteins synthesis by mature osteoblast enriched cells. The effects of strontium ranelate on bone formation were confirmed as strontium ranelate enhanced pre-osteoblastic cell replication. The stimulation by strontium ranelate of the replication of osteoprogenitor cell and collagen, as well as noncollagenic protein synthesis in osteoblasts, provides substantial evidence to categorize strontium ranelate as a bone-forming agent. In the isolated rat osteoclast assay, a pre-incubation of bone slices with strontium ranelate induced a dose- dependent inhibition of the bone resorbing activity of treated rat osteoclast. Strontium ranelate also dose-dependently inhibited, in a chicken bone marrow culture, the expression of both carbonic anhydrase II and the alpha-subunit of the vitronectin receptor. These effects showing that strontium ranelate significantly affects bone resorption due to a direct and/or matrix-mediated inhibition of osteoclast activity and also inhibits osteoclasts differentiation, are compatible with the profile of an anti-resorptive drug. Pharmacological and clinical studies suggest that strontium ranelate optimizes bone resorption and bone formation, resulting in increased bone mass, which may be of great value in the treatment of osteoporosis. Strontium ranelate is approved by EMA for the treatment of severe osteoporosis in postmenopausal women and in adult men.

CNS Activity

Curator's Comment: Strontium ranelate had no behavioural effects, no CNS toxicity nor CNS accumulation demonstrated with Strontium ranelate in the non-clinical studies.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PROTELOS

Approved Use

Treatment of severe osteoporosis: - in postmenopausal women, - in adult men, at high risk of fracture, for whom treatment with other medicinal products approved for the treatment of osteoporosis is not possible due to, for example, contraindications or intolerance. In postmenopausal women, strontium ranelate reduces the risk of vertebral and hip fractures.

Launch Date

1.09563838E12
PubMed

PubMed

TitleDatePubMed
Adequacy of dialysis: trace elements in dialysis fluids.
1996
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.
1999 May
Inhibition of HIV-1 infection by zinc group metal compounds.
1999 Sep
Delay of natural bone loss by higher intakes of specific minerals and vitamins.
2001 May
Strontium ranelate: a novel mode of action optimizing bone formation and resorption.
2005 Jan
Osteoporosis: non-hormonal treatment.
2007 Oct
Could strontium ranelate have a synergistic role in the treatment of osteoporosis?
2009 Aug
Mechanism of action of strontium ranelate: what are the facts?
2010 Jan
The position of strontium ranelate in today's management of osteoporosis.
2015 Jun
Strontium ranelate, a promising disease modifying osteoarthritis drug.
2017 Mar
Strontium and strontium ranelate: Historical review of some of their functions.
2017 Sep 1
Patents

Sample Use Guides

The recommended dose is one sachet containing 2 g of strontium ranelate once daily by oral administration.
Route of Administration: Oral
Osteoblastic MC3TE-E1 cell cultures exposed to Strontium ranelate (SR) at 0.5 mM exhibited a decrease in both cell proliferation and cell viability in all time points assayed. High levels of protein and mRNA for Type I Collagen and Osteopontin were detected in cultures exposed to SR, particularly at 0.5 mM. SR allowed the expression of fibronectin in osteoblastic cell cultures as observed by epifluorescence analysis. The mineralized bone-like nodule formation was affected in a concentration-dependent manner by SR, with large bone-like nodules being detected in osteoblastic cell cultures exposed to SR at 0.5 mM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:03:49 UTC 2023
Edited
by admin
on Fri Dec 15 17:03:49 UTC 2023
Record UNII
41YPU4MMCA
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
STRONTIUM CARBONATE
HSDB   MI  
Systematic Name English
CARBONIC ACID, STRONTIUM SALT (1:1)
Common Name English
STRONTIUM CARBONATE (SRCO3)
Common Name English
STRONTIUM CARBONATE [HSDB]
Common Name English
NSC-112224
Code English
CI 77837
Common Name English
STRONTIUM CARBONICUM [HPUS]
Common Name English
STRONTIUM CARBONICUM
HPUS  
Common Name English
STRONTIANITE
Common Name English
STRONTIUM CARBONATE [MI]
Common Name English
Strontium carbonas [WHO-DD]
Common Name English
STRONTIUM CARBONAS
WHO-DD  
Common Name English
Code System Code Type Description
MESH
C054286
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
DAILYMED
41YPU4MMCA
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
RXCUI
1311308
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
FDA UNII
41YPU4MMCA
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
EPA CompTox
DTXSID3029651
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
HSDB
5845
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
NSC
112224
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
SMS_ID
100000178338
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
ECHA (EC/EINECS)
216-643-7
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
EVMPD
SUB194066
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
MERCK INDEX
m10238
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY Merck Index
PUBCHEM
15407
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
CAS
1633-05-2
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
WIKIPEDIA
STRONTIUM CARBONATE
Created by admin on Fri Dec 15 17:03:49 UTC 2023 , Edited by admin on Fri Dec 15 17:03:49 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
ACTIVE MOIETY