TROQUIDAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H15N5O3
Molecular Weight	301.3006
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][N+](=O)C1=C(NC(=N)N2CCOCC2)C3=C(C=CC=C3)N=C1

InChI

InChIKey=UUJSXEHRMRPYEX-UHFFFAOYSA-N

InChI=1S/C14H15N5O3/c15-14(18-5-7-22-8-6-18)17-13-10-3-1-2-4-11(10)16-9-12(13)19(20)21/h1-4,9H,5-8H2,(H2,15,16,17)

HIDE SMILES / InChI

Molecular Formula	C14H15N5O3
Molecular Weight	301.3006
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_toc_pr?p_JournalID=2&p_IssueID=266 | https://www.ncbi.nlm.nih.gov/pubmed/2086588

Troquidazole (EGIS-4136) is a radiosensitizer. It is a nitroquinoline derivative which enhances the radiosensitivity of hamster’s ovarian cells in both normoxia and hypoxia. Misonidazole at a concentration of 5 mM exerted a radiosensitizing effect as strong as 0.5 mM EGIS-4136.

Approval Year

PubMed

Title	Date	PubMed
Determination of N-(3-nitro-4-quinoline)morpholino-4-carboxamidine in plasma high-performance liquid chromatography.	1990 Nov 9	2086588

Patents

Sample Use Guides

In Vivo Use Guide

Rats: single oral dose of 50 mg/kg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:42:21 GMT 2023` Edited by `admin` on `Sat Dec 16 16:42:21 GMT 2023`
Record UNII	41X4FOR202
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TROQUIDAZOLE

Official Name

English

troquidazole [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C277