PERFLUORO TERT-BUTYLCYCLOHEXANE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10F20
Molecular Weight	500.0751
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PERFLUORO TERT-BUTYLCYCLOHEXANE

Structure Search

SMILES

FC(F)(F)C(C(F)(F)F)(C(F)(F)F)C1(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F

InChI

InChIKey=VLTXBOGHSBHSAC-UHFFFAOYSA-N

InChI=1S/C10F20/c11-2(1(8(22,23)24,9(25,26)27)10(28,29)30)3(12,13)5(16,17)7(20,21)6(18,19)4(2,14)15

HIDE SMILES / InChI

Molecular Formula	C10F20
Molecular Weight	500.0751
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18165547 | https://www.ncbi.nlm.nih.gov/pubmed/29356218 | https://www.ncbi.nlm.nih.gov/pubmed/24025081 | https://www.ncbi.nlm.nih.gov/pubmed/18431491

Perfluoro tert-butylcyclohexane (PTBCH) is a perfluorocarbon emulsion that acts as a highly effective oxygen carrier compared to blood. Administration of PTBCH significantly increased parenchymal tissue oxygen levels during the usual post-injury hypoxic phase, and PTBCH has been shown to be effective in stroke and head injury. Administration of PTBCH during cardiopulmonary bypass was associated with an excessive release of cytokines. This enhanced inflammatory response with subsequent hypotension may have contributed to mortality in rats receiving PTBCH. The observed patterns of myocardial injury indicate global hypoperfusion and catecholamine excess.

Approval Year

PubMed

Title	Date	PubMed
Brain oxygenation with a non-vasoactive perfluorocarbon emulsion in a rat model of traumatic brain injury.	2018-04	29356218
The Emulsified PFC Oxycyte® Improved Oxygen Content and Lung Injury Score in a Swine Model of Oleic Acid Lung Injury (OALI).	2016-12	27704259
The effect of the perfluorocarbon emulsion Oxycyte on platelet count and function in the treatment of decompression sickness in a swine model.	2016-09	26650458
In vitro alteration of hematological parameters and blood viscosity by the perfluorocarbon: Oxycyte.	2016-05	26886450
Cardiovascular parameters in a mixed-sex swine study of severe decompression sickness treated with the emulsified perfluorocarbon Oxycyte.	2015-01-01	25342702
Neuroprotective effects of perflurocarbon (oxycyte) after contusive spinal cord injury.	2014-02-01	24025081
Pefluorocarbon inhibition of bubble induced Ca2+ transients in an in vitro model of vascular gas embolism.	2014-01	24131543
Administration of a second generation perfluorochemical in combination with hyperbaric oxygenation does not provide additional benefit in a model of permanent middle cerebral artery occlusion in rats.	2014	25674426
The effect of isovolemic hemodilution with oxycyte, a perfluorocarbon emulsion, on cerebral blood flow in rats.	2008-04-23	18431491
Perfluorocarbon administration during cardiopulmonary bypass in rats: an inflammatory link to adverse outcome?	2008-01	18165547

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:33:13 GMT 2025` Edited by `admin` on `Mon Mar 31 18:33:13 GMT 2025`
Record UNII	3ZX1Z33VUU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PERFLUORO T-BUTYLCYCLOHEXANE

Preferred Name

English

PERFLUORO TERT-BUTYLCYCLOHEXANE

Systematic Name

English

PERFLUORO(TERT-BUTYLCYCLOHEXANE)

Systematic Name

English

PERFLUORO(1,1-DIMETHYLETHYL)CYCLOHEXANE

Systematic Name

English

CYCLOHEXANE, 1,1,2,2,3,3,4,4,5,5,6-UNDECAFLUORO-6-(2,2,2-TRIFLUORO-1,1-BIS(TRIFLUOROMETHYL)ETHYL)-

Systematic Name

English

OXYCYTE

Brand Name

English

CYCLOHEXANE, UNDECAFLUORO(2,2,2-TRIFLUORO-1,1-BIS(TRIFLUOROMETHYL)ETHYL)-

Systematic Name

English

Code System Code Type Description

SMS_ID

300000041530