Stereochemistry | ABSOLUTE |
Molecular Formula | C23H29NO12 |
Molecular Weight | 511.4759 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 10 / 10 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12OCO[C@@]1([H])[C@H](O)[C@H](NC(=O)C(\C)=C\C3=CC=C(O[C@@H]4O[C@@H]([C@@H](O)[C@@H]4O)C(C)=O)C(O)=C3)[C@H](O)[C@H]2O
InChI
InChIKey=YQYJSBFKSSDGFO-IIHALWDASA-N
InChI=1S/C23H29NO12/c1-8(22(32)24-13-14(27)16(29)21-20(15(13)28)33-7-34-21)5-10-3-4-12(11(26)6-10)35-23-18(31)17(30)19(36-23)9(2)25/h3-6,13-21,23,26-31H,7H2,1-2H3,(H,24,32)/b8-5+/t13-,14+,15-,16-,17+,18+,19-,20+,21-,23-/m1/s1
Molecular Formula | C23H29NO12 |
Molecular Weight | 511.4759 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 10 / 10 |
E/Z Centers | 1 |
Optical Activity | UNSPECIFIED |
Hygromycin A, an antibiotic produced by Streptomyces hiygroscopicus, is active against gram-positive bacteria including mycobacteria and actinomycetes, as well as against endomoeba, leptospira and pleuro- pneumonia-like organisms. Hygromycin A binds strongly to bacterial ribosomes and inhibits the ribosomal peptidyl transferase activity. The antibiotic binds to the ribosome in a distinct but overlapping manner with other antibiotics and offers a different template for generation of new agents effective against multidrug-resistant pathogens.