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Approval Year

Unknown
139594
Substance Class
Concept
Record UNII
3Y7ANB3DKG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GI-101
Code English
GI 101 [WHO-DD]
Common Name English
Bi-specific fragment crystallizable region (Fc) fusion protein containing cluster of differentiation 80 ectodomain as an N-terminal moiety and interleukin-2 variant as a C-terminal moiety conjugated with human immunoglobulin G4 Fc
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 905422
Created by admin on Sat Dec 16 19:11:14 GMT 2023 , Edited by admin on Sat Dec 16 19:11:14 GMT 2023
Code System Code Type Description
FDA UNII
3Y7ANB3DKG
Created by admin on Sat Dec 16 19:11:14 GMT 2023 , Edited by admin on Sat Dec 16 19:11:14 GMT 2023
PRIMARY
This is a non-substance concept
Related Record Type Details
CYTOTOXIC T-LYMPHOCYTE PROTEIN 4
TARGET -> INHIBITOR
IN-VIVO
T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
TARGET -> ACTIVATOR
GI101 has high binding affinity to CTLA4 acting as a decoy ligand, thereby enhancing the interaction between endogenous CD80 and CD28, leading to the activation of T cells
IN-VIVO
Interleukin-2 receptor subunit beta and gamma complex
TARGET->LIGAND
Related Record Type Details
GI-101
ACTIVE MOIETY
This is a non-substance concept
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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National Center for Advancing Translational Sciences (NCATS),
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