Patritumab Deruxtecan

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:21:00 GMT 2025` Edited by `admin` on `Tue Apr 01 23:21:00 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	3XPI7EG4W8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Patritumab Deruxtecan

Official Name

English

U3-1402

Preferred Name

English

ANTI-HER3 ANTIBODY-DRUG CONJUGATE U3 1402

Common Name

English

patritumab deruxtecan [INN]

Common Name

English

U3-1402A

Code

English

PATRITUMAB DERUXTECAN [JAN]

Common Name

English

Immunoglobulin G1, anti-(human epidermal growth factor receptor HER3) (human monoclonal U3-1287 ?1-chain), complex with human monoclonal U3-1287 ?-chain, dimer, octakis(thioether) with N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]glycylglycyl-L-

Common Name

English

U31402

Code

English

Patritumab deruxtecan [WHO-DD]

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3)], Homo sapiens monoclonal antibody, conjugated to deruxtecan, comprising a linker and a camptothecin derivative; gamma1 heavy chain Homo sapiens (1-447) [VH

Common Name

English

PATRITUMAB DERUXTECAN [USAN]

Common Name

English

Code System Code Type Description

SMS_ID

300000010791

Created by admin on Tue Apr 01 23:21:00 GMT 2025 , Edited by admin on Tue Apr 01 23:21:00 GMT 2025

PRIMARY

INN

11093

Created by admin on Tue Apr 01 23:21:00 GMT 2025 , Edited by admin on Tue Apr 01 23:21:00 GMT 2025

PRIMARY

USAN

KL-231

Created by admin on Tue Apr 01 23:21:00 GMT 2025 , Edited by admin on Tue Apr 01 23:21:00 GMT 2025

PRIMARY

CAS

2227102-46-5

Created by admin on Tue Apr 01 23:21:00 GMT 2025 , Edited by admin on Tue Apr 01 23:21:00 GMT 2025

PRIMARY

FDA UNII

3XPI7EG4W8

Created by admin on Tue Apr 01 23:21:00 GMT 2025 , Edited by admin on Tue Apr 01 23:21:00 GMT 2025

PRIMARY

NCI_THESAURUS

C136987

Created by admin on Tue Apr 01 23:21:00 GMT 2025 , Edited by admin on Tue Apr 01 23:21:00 GMT 2025

PRIMARY

From	To
1_22	1_95
1_144	1_200
1_261	1_321
1_367	1_425
2_22	2_95
2_144	2_200
2_261	2_321
2_367	2_425
3_23	3_94
3_140	3_200
4_23	4_94
4_140	4_200

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_52
N	1_297
N	2_52
N	2_297

Related Record Type Details


					RSO83C9PIA

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3

TARGET->LIGAND

Amount:


					86780VJI1Q

PARENT -> DERIVATIVE

Amount:


					FUV56ZH0GB

DNA TOPOISOMERASE 1

TARGET->CONJUGATED TOXIN

Amount:

Related Record Type Details


					3XPI7EG4W8

Patritumab Deruxtecan

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_220] [1_226] [1_229] [2_220] [2_226] [2_229] [3_220] [4_220]	SITE_SPECIFIC			CYSTEINYL DERUXTECAN	I1NS1DHT5R

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL