BIS(2-CYANOETHYL)AMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H9N3
Molecular Weight	123.1558
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N#CCCNCCC#N

InChI

InChIKey=SBAJRGRUGUQKAF-UHFFFAOYSA-N

InChI=1S/C6H9N3/c7-3-1-5-9-6-2-4-8/h9H,1-2,5-6H2

HIDE SMILES / InChI

Molecular Formula	C6H9N3
Molecular Weight	123.1558
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
The ototoxicity of 3,3'-iminodipropionitrile: functional and morphological evidence of cochlear damage.	1994 Nov	7896571
Characterization of olfactory deficits in the rat following administration of 2,6-dichlorobenzonitrile (dichlobenil), 3,3'-iminodipropionitrile, or methimazole.	1996 Jan	8838641
Behavioural disturbances and sensory pathology following allylnitrile exposure in rats.	2001 Jun 22	11406128
Pathology of the rat vestibular sensory epithelia during subchronic 3,3'-iminodipropionitrile exposure: hair cells may not be the primary target of toxicity.	2001 Oct	11603809
Relationship between insult intensity and mode of hair cell loss in the vestibular system of rats exposed to 3,3'-iminodipropionitrile.	2001 Oct 29	11596061
Masses of phosphorylated neurofilaments are associated with abnormal golgi apparatus of anterior horn neurons of beta, beta'-iminodipropionitrile-intoxicated rats.	2002 Jun	12075937
Attenuation of iminodipropionitrile induced behavioral syndrome by sodium salicylate in rats.	2002 Oct	12151040
Expression of neurotransmitter genes in motor regions of the dyskinetic rat after iminodipropionitrile.	2003 Aug 14	12865138
A hypothetical mathematical construct explaining the mechanism of biological amplification in an experimental model utilizing picoTesla (PT) electromagnetic fields.	2003 Jun	12699707
Comparison of cis- and trans-crotononitrile effects in the rat reveals specificity in the neurotoxic properties of nitrile isomers.	2003 Mar 1	12649041
[Neurobehavioral toxicity of acrylamide and IDPN (3,3'-iminodipropionitrile) in rats by 28-day oral administration--problems encountered in collaborative study and a commentary on conducting neurobehavioral testing].	2003 May	12822443
Three-dimensional mapping of the lesions induced by beta-beta'-iminodiproprionitrile, methyl iodide and methyl methacrylate in the rat nasal cavity.	2003 May-Jun	12746123
Distal effects in a model of proximal axonopathy: 3,3'-iminodipropionitrile causes specific loss of neurofilaments in rat vestibular afferent endings.	2003 Nov	12898157
Influence of age on iminodipropionitrile-induced vestibular and neurobehavioral toxicities in rats.	2003 Sep	14620540
Inhibitory effect of free radical scavenger, MCI-186, in the increase of hydroxyl radical induced by iminodipropionitrile in rats.	2004 Apr 15	15050436
Sodium benzoate attenuates iminodipropionitrile-induced behavioral syndrome in rats.	2004 Dec	15577457
Retinal microvascular patency in the diabetic rat.	2004 Jul	16200444
Metoclopramide attenuates iminodipropionitrile-induced oxidative stress and neurobehavioral toxicity in rats.	2004 Nov	15582028
On the similarity of cocaine and 3,3'-iminodipropionitrile.	2005	15893140
Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer.	2005	15607570
Behavioral and pathological effects in the rat define two groups of neurotoxic nitriles.	2005 Dec	16150883
Does copper ameliorate the vestibular toxicity of iminodipropionitrile (IDPN)?	2005 Jun	15885797
The neurotoxicity of iminodipropionitrile (IDPN) is ameliorated by copper.	2005 Mar	15713348
Extruding auditory hair cells in rats exposed to subchronic 3,3'-iminodipropionitrile.	2005 May	21783528
Mechanism of neurotoxic 3,3'-iminodipropionitrile: relation to unsaturated nitriles, cocaine, and reactive oxygen species.	2006	16188394
Propagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters.	2007 Jan-Feb	17181988
Protective effect of hydrocortisone on iminodipropionitrile-induced neurotoxicity in rats.	2007 Mar	17309521
Behavioral disturbances and hair cell loss in the inner ear following nitrile exposure in mice, guinea pigs, and frogs.	2007 Mar	17159233
Requirement of vimentin filament assembly for beta3-adrenergic receptor activation of ERK MAP kinase and lipolysis.	2007 Mar 23	17251187
[Curative effect and possible mechanisms of topiramate in treatment of Tourette syndrome in rats].	2008 Aug	18706175
Phosphorylation and compactness of neurofilaments in multiple sclerosis: indicators of axonal pathology.	2008 Oct	18619438
Pentoxifylline attenuates iminodipropionitrile-induced behavioral abnormalities in rats.	2009 Jul	19584713
Nervous and vestibular toxicities of acrylonitrile and iminodipropionitrile.	2009 Jul	19403855
Neurovestibular toxicities of acrylonitrile and iminodipropionitrile in rats: a comparative evaluation of putative mechanisms and target sites.	2009 May	19244277
Clinical physiology and mechanism of dizocilpine (MK-801): electron transfer, radicals, redox metabolites and bioactivity.	2010 Jan-Feb	20716924
Acute reproductive toxicity of 3,3'-iminodipropionitrile in female rats.	2012 Jan	22074697
Role of CYP2E1-mediated metabolism in the acute and vestibular toxicities of nineteen nitriles in the mouse.	2012 Jan 25	22051853
Acute toxic effects of 3,3'-iminodipropionitrile on hypothalamic-pituitary-gonadal axis in male rats.	2014 Jan	24172839

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:07:17 GMT 2023` Edited by `admin` on `Fri Dec 15 18:07:17 GMT 2023`
Record UNII	3XP1CVU865
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BIS(2-CYANOETHYL)AMINE

Systematic Name

English

3,3'-IMINODIPROPIONITRILE

Systematic Name

English

BIS-(2-CYANOETHYL)AMINE

Systematic Name

English

BIS(.BETA.-CYANOETHYL)AMINE

Systematic Name

English

3,3'-IMINOBISPROPANENITRILE

Systematic Name

English

.BETA.,.BETA.'-IMINODIPROPIONITRILE [HSDB]

Common Name

English

NSC-7770

Code

English

Classification Tree Code System Code

EPA PESTICIDE CODE

600004