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Details

Stereochemistry ABSOLUTE
Molecular Formula C23H32O6
Molecular Weight 404.4966
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROCORTISONE ACETATE

SMILES

[H][C@@]12CC[C@](O)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])CCC4=CC(=O)CC[C@]34C

InChI

InChIKey=ALEXXDVDDISNDU-JZYPGELDSA-N
InChI=1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

HIDE SMILES / InChI

Molecular Formula C23H32O6
Molecular Weight 404.4966
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 7 / 7
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/008697s032_33lbl.pdf

Hydrocortisone is the main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In other words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). Hydrocortisone is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

CNS Activity

Curator's Comment: shown in dogs

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Cortef

Approved Use

CORTEF Tablets are indicated in the following conditions. 1. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance) Congenital adrenal hyperplasia Non suppurative thyroiditis Hypercalcemia associated with cancer 2. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Psoriatic arthritis Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy) Ankylosing spondylitis Acute and subacute bursitis Acute nonspecific tenosynovitis Acute gouty arthritis Post-traumatic osteoarthritis Synovitis of osteoarthritis Epicondylitis 3. Collagen Diseases During an exacerbation or as maintenance therapy in selected cases of: Systemic lupus erythematosus Systemic dermatomyositis (polymyositis) Acute rheumatic carditis 4. Dermatologic Diseases Pemphigus Bullous dermatitis herpetiformis Severe erythema multiforme (Stevens-Johnson syndrome) Exfoliative dermatitis Mycosis fungoides Severe psoriasis Severe seborrheic dermatitis 5. Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: Seasonal or perennial allergic rhinitis Serum sickness Bronchial asthma Contact dermatitis Atopic dermatitis Drug hypersensitivity reactions 6. Ophthalmic Diseases Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: Allergic conjunctivitis Keratitis Allergic corneal marginal ulcers Herpes zoster ophthalmicus Iritis and iridocyclitis Chorioretinitis Anterior segment inflammation Diffuse posterior uveitis and choroiditis Optic neuritis Sympathetic ophthalmia 7. Respiratory Diseases Symptomatic sarcoidosis Loeffler’s syndrome not manageable by other means Berylliosis Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy Aspiration pneumonitis 8. Hematologic Disorders Idiopathic thrombocytopenic purpura in adults Secondary thrombocytopenia in adults Acquired (autoimmune) hemolytic anemia Erythroblastopenia (RBC anemia) Congenital (erythroid) hypoplastic anemia 9. Neoplastic Diseases For palliative management of: Leukemias and lymphomas in adults Acute leukemia of childhood 10. Edematous States To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. 11. Gastrointestinal Diseases To tide the patient over a critical period of the disease in: Ulcerative colitis Regional enteritis 12. Nervous System Acute exacerbations of multiple sclerosis 13. Miscellaneous Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy Trichinosis with neurologic or myocardial involvement

Launch Date

1952
Primary
Cortef

Approved Use

CORTEF Tablets are indicated in the following conditions. 1. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance) Congenital adrenal hyperplasia Non suppurative thyroiditis Hypercalcemia associated with cancer 2. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Psoriatic arthritis Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy) Ankylosing spondylitis Acute and subacute bursitis Acute nonspecific tenosynovitis Acute gouty arthritis Post-traumatic osteoarthritis Synovitis of osteoarthritis Epicondylitis 3. Collagen Diseases During an exacerbation or as maintenance therapy in selected cases of: Systemic lupus erythematosus Systemic dermatomyositis (polymyositis) Acute rheumatic carditis 4. Dermatologic Diseases Pemphigus Bullous dermatitis herpetiformis Severe erythema multiforme (Stevens-Johnson syndrome) Exfoliative dermatitis Mycosis fungoides Severe psoriasis Severe seborrheic dermatitis 5. Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: Seasonal or perennial allergic rhinitis Serum sickness Bronchial asthma Contact dermatitis Atopic dermatitis Drug hypersensitivity reactions 6. Ophthalmic Diseases Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: Allergic conjunctivitis Keratitis Allergic corneal marginal ulcers Herpes zoster ophthalmicus Iritis and iridocyclitis Chorioretinitis Anterior segment inflammation Diffuse posterior uveitis and choroiditis Optic neuritis Sympathetic ophthalmia 7. Respiratory Diseases Symptomatic sarcoidosis Loeffler’s syndrome not manageable by other means Berylliosis Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy Aspiration pneumonitis 8. Hematologic Disorders Idiopathic thrombocytopenic purpura in adults Secondary thrombocytopenia in adults Acquired (autoimmune) hemolytic anemia Erythroblastopenia (RBC anemia) Congenital (erythroid) hypoplastic anemia 9. Neoplastic Diseases For palliative management of: Leukemias and lymphomas in adults Acute leukemia of childhood 10. Edematous States To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. 11. Gastrointestinal Diseases To tide the patient over a critical period of the disease in: Ulcerative colitis Regional enteritis 12. Nervous System Acute exacerbations of multiple sclerosis 13. Miscellaneous Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy Trichinosis with neurologic or myocardial involvement

Launch Date

1952
Palliative
Cortef

Approved Use

CORTEF Tablets are indicated in the following conditions. 1. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance) Congenital adrenal hyperplasia Non suppurative thyroiditis Hypercalcemia associated with cancer 2. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Psoriatic arthritis Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy) Ankylosing spondylitis Acute and subacute bursitis Acute nonspecific tenosynovitis Acute gouty arthritis Post-traumatic osteoarthritis Synovitis of osteoarthritis Epicondylitis 3. Collagen Diseases During an exacerbation or as maintenance therapy in selected cases of: Systemic lupus erythematosus Systemic dermatomyositis (polymyositis) Acute rheumatic carditis 4. Dermatologic Diseases Pemphigus Bullous dermatitis herpetiformis Severe erythema multiforme (Stevens-Johnson syndrome) Exfoliative dermatitis Mycosis fungoides Severe psoriasis Severe seborrheic dermatitis 5. Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: Seasonal or perennial allergic rhinitis Serum sickness Bronchial asthma Contact dermatitis Atopic dermatitis Drug hypersensitivity reactions 6. Ophthalmic Diseases Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: Allergic conjunctivitis Keratitis Allergic corneal marginal ulcers Herpes zoster ophthalmicus Iritis and iridocyclitis Chorioretinitis Anterior segment inflammation Diffuse posterior uveitis and choroiditis Optic neuritis Sympathetic ophthalmia 7. Respiratory Diseases Symptomatic sarcoidosis Loeffler’s syndrome not manageable by other means Berylliosis Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy Aspiration pneumonitis 8. Hematologic Disorders Idiopathic thrombocytopenic purpura in adults Secondary thrombocytopenia in adults Acquired (autoimmune) hemolytic anemia Erythroblastopenia (RBC anemia) Congenital (erythroid) hypoplastic anemia 9. Neoplastic Diseases For palliative management of: Leukemias and lymphomas in adults Acute leukemia of childhood 10. Edematous States To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. 11. Gastrointestinal Diseases To tide the patient over a critical period of the disease in: Ulcerative colitis Regional enteritis 12. Nervous System Acute exacerbations of multiple sclerosis 13. Miscellaneous Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy Trichinosis with neurologic or myocardial involvement

Launch Date

1952
Primary
Cortef

Approved Use

CORTEF Tablets are indicated in the following conditions. 1. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance) Congenital adrenal hyperplasia Non suppurative thyroiditis Hypercalcemia associated with cancer 2. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Psoriatic arthritis Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy) Ankylosing spondylitis Acute and subacute bursitis Acute nonspecific tenosynovitis Acute gouty arthritis Post-traumatic osteoarthritis Synovitis of osteoarthritis Epicondylitis 3. Collagen Diseases During an exacerbation or as maintenance therapy in selected cases of: Systemic lupus erythematosus Systemic dermatomyositis (polymyositis) Acute rheumatic carditis 4. Dermatologic Diseases Pemphigus Bullous dermatitis herpetiformis Severe erythema multiforme (Stevens-Johnson syndrome) Exfoliative dermatitis Mycosis fungoides Severe psoriasis Severe seborrheic dermatitis 5. Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: Seasonal or perennial allergic rhinitis Serum sickness Bronchial asthma Contact dermatitis Atopic dermatitis Drug hypersensitivity reactions 6. Ophthalmic Diseases Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: Allergic conjunctivitis Keratitis Allergic corneal marginal ulcers Herpes zoster ophthalmicus Iritis and iridocyclitis Chorioretinitis Anterior segment inflammation Diffuse posterior uveitis and choroiditis Optic neuritis Sympathetic ophthalmia 7. Respiratory Diseases Symptomatic sarcoidosis Loeffler’s syndrome not manageable by other means Berylliosis Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy Aspiration pneumonitis 8. Hematologic Disorders Idiopathic thrombocytopenic purpura in adults Secondary thrombocytopenia in adults Acquired (autoimmune) hemolytic anemia Erythroblastopenia (RBC anemia) Congenital (erythroid) hypoplastic anemia 9. Neoplastic Diseases For palliative management of: Leukemias and lymphomas in adults Acute leukemia of childhood 10. Edematous States To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. 11. Gastrointestinal Diseases To tide the patient over a critical period of the disease in: Ulcerative colitis Regional enteritis 12. Nervous System Acute exacerbations of multiple sclerosis 13. Miscellaneous Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy Trichinosis with neurologic or myocardial involvement

Launch Date

1952
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
258 ng/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
HYDROCORTISONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1162 ng × h/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
HYDROCORTISONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
1.82 h
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
HYDROCORTISONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
9.9%
HYDROCORTISONE plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
200 mg 4 times / day multiple, intramuscular
Highest studied dose
Dose: 200 mg, 4 times / day
Route: intramuscular
Route: multiple
Dose: 200 mg, 4 times / day
Sources:
unhealthy, 56 years (tange: 40-64 years)
n = 10
Health Status: unhealthy
Condition: primary adrenal insufficiency
Age Group: 56 years (tange: 40-64 years)
Sex: M+F
Population Size: 10
Sources:
200 mg 4 times / day multiple, intravenous
Highest studied dose
Dose: 200 mg, 4 times / day
Route: intravenous
Route: multiple
Dose: 200 mg, 4 times / day
Sources:
unhealthy, 56 years (tange: 40-64 years)
n = 10
Health Status: unhealthy
Condition: primary adrenal insufficiency
Age Group: 56 years (tange: 40-64 years)
Sex: M+F
Population Size: 10
Sources:
200 mg 4 times / day multiple, oral
Highest studied dose
Dose: 200 mg, 4 times / day
Route: oral
Route: multiple
Dose: 200 mg, 4 times / day
Sources:
unhealthy, 56 years (tange: 40-64 years)
n = 10
Health Status: unhealthy
Condition: primary adrenal insufficiency
Age Group: 56 years (tange: 40-64 years)
Sex: M+F
Population Size: 10
Sources:
200 mg single, intravenous
Highest studied dose
Dose: 200 mg
Route: intravenous
Route: single
Dose: 200 mg
Sources:
unhealthy, 56 years (tange: 40-64 years)
n = 10
Health Status: unhealthy
Condition: primary adrenal insufficiency
Age Group: 56 years (tange: 40-64 years)
Sex: M+F
Population Size: 10
Sources:
2.5 % 4 times / day multiple, topical
Dose: 2.5 %, 4 times / day
Route: topical
Route: multiple
Dose: 2.5 %, 4 times / day
Sources:
unhealthy, adult
1 mg/kg 4 times / day multiple, intravenous
Dose: 1 mg/kg, 4 times / day
Route: intravenous
Route: multiple
Dose: 1 mg/kg, 4 times / day
Sources:
unhealthy, children
n = 23
Health Status: unhealthy
Condition: vasoactive infusion
Age Group: children
Population Size: 23
Sources:
Other AEs: Infection...
Other AEs:
Infection (below serious, 6 patients)
Sources:
0.5 mg/kg 4 times / day multiple, intravenous
Dose: 0.5 mg/kg, 4 times / day
Route: intravenous
Route: multiple
Dose: 0.5 mg/kg, 4 times / day
Sources:
unhealthy, neonate
n = 6
Health Status: unhealthy
Condition: Cardiovascular Insufficiency
Age Group: neonate
Population Size: 6
Sources:
Other AEs: Hyperbilirubinemia, Hypertension...
Other AEs:
Hyperbilirubinemia (serious, 1 patient)
Hypertension (serious, 1 patient)
Adrenal insufficiency (serious, 1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Infection below serious, 6 patients
1 mg/kg 4 times / day multiple, intravenous
Dose: 1 mg/kg, 4 times / day
Route: intravenous
Route: multiple
Dose: 1 mg/kg, 4 times / day
Sources:
unhealthy, children
n = 23
Health Status: unhealthy
Condition: vasoactive infusion
Age Group: children
Population Size: 23
Sources:
Adrenal insufficiency serious, 1 patient
0.5 mg/kg 4 times / day multiple, intravenous
Dose: 0.5 mg/kg, 4 times / day
Route: intravenous
Route: multiple
Dose: 0.5 mg/kg, 4 times / day
Sources:
unhealthy, neonate
n = 6
Health Status: unhealthy
Condition: Cardiovascular Insufficiency
Age Group: neonate
Population Size: 6
Sources:
Hyperbilirubinemia serious, 1 patient
0.5 mg/kg 4 times / day multiple, intravenous
Dose: 0.5 mg/kg, 4 times / day
Route: intravenous
Route: multiple
Dose: 0.5 mg/kg, 4 times / day
Sources:
unhealthy, neonate
n = 6
Health Status: unhealthy
Condition: Cardiovascular Insufficiency
Age Group: neonate
Population Size: 6
Sources:
Hypertension serious, 1 patient
0.5 mg/kg 4 times / day multiple, intravenous
Dose: 0.5 mg/kg, 4 times / day
Route: intravenous
Route: multiple
Dose: 0.5 mg/kg, 4 times / day
Sources:
unhealthy, neonate
n = 6
Health Status: unhealthy
Condition: Cardiovascular Insufficiency
Age Group: neonate
Population Size: 6
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG


OverviewOther

Other InhibitorOther SubstrateOther Inducer



Drug as perpetrator​Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
major
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Functional adrenocorticotropic hormone receptor in cultured human vascular endothelial cells : possible role in control of blood pressure.
2000 Nov
The stress hormone, cortisol, synergizes with HIV-1 gp-120 to induce apoptosis of normal human peripheral blood mononuclear cells.
2000 Nov
Methotrexate treatment protocols and the central nervous system: significant cure with significant neurotoxicity.
2000 Sep
Inducers of gamma-glutamylcysteine synthetase and their effects on glutathione synthetase expression.
2000 Sep 7
Endocrine and metabolic effects of insulin sensitizers in the treatment of patients with polycystic ovary syndrome and hyperinsulinaemia.
2001
Circulatory support of the sick preterm infant.
2001 Feb
Interactions among paternal behavior, steroid hormones, and parental experience in male marmosets (Callithrix kuhlii).
2001 Feb
Menstrual cycle variation in spatial ability: relation to salivary cortisol levels.
2001 Feb
Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching.
2001 Feb
Glucocorticoids protect against apoptosis induced by serum deprivation, cyclic adenosine 3',5'-monophosphate and p53 activation in immortalized human granulosa cells: involvement of Bcl-2.
2001 Feb
PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells.
2001 Feb
Postnatal glucocorticoids in very preterm infants: "the good, the bad, and the ugly"?
2001 Feb
The patients with incidentally discovered adrenal adenoma (incidentaloma) are not at increased risk of osteoporosis.
2001 Feb
Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studies.
2001 Feb
Fertility and body composition after laparoscopic bilateral adrenalectomy in a 30-year-old female with congenital adrenal hyperplasia.
2001 Feb
Electrophysiological effects of corticosteroids on the retinal pigment epithelium.
2001 Feb
Switch from systemic steroids to budesonide in steroid dependent patients with inactive Crohn's disease.
2001 Feb
Dose response of arginine vasopressin to the CCK-B agonist pentagastrin.
2001 Feb
Neuroendocrine and behavioral responses to mCPP in Obsessive-Compulsive Disorder.
2001 Feb
Relationship functioning and home and work demands predict individual differences in diurnal cortisol patterns in women.
2001 Feb
Abnormalities in response to vasopressin infusion in chronic fatigue syndrome.
2001 Feb
Use of salivary biomarkers in biobehavioral research: cotton-based sample collection methods can interfere with salivary immunoassay results.
2001 Feb
Post-dexamethasone cortisol level and memory performance in elderly depressed patients.
2001 Feb 2
Inhibition of cortisol secretion in dispersed head kidney cells of rainbow trout (Oncorhynchus mykiss) by endosulfan, an organochlorine pesticide.
2001 Jan
Tixocortol pivalate contact allergy in the GPMT: frequency and cross-reactivity.
2001 Jan
Growth hormone deficiency caused by pituitary stalk interruption in Fanconi's anemia.
2001 Jan
Back to basics: early diagnosis and compliance improve final height outcome in congenital adrenal hyperplasia.
2001 Jan
Serum thyrotropin concentrations and bioactivity during sleep deprivation in depression.
2001 Jan
Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice.
2001 Jan
Localization and developmental regulation of 11beta-hydroxysteroid dehydrogenase-1 and -2 in the baboon syncytiotrophoblast.
2001 Jan
Effects of cortisol on chloride cells in the gill epithelium of Japanese eel, Anguilla japonica.
2001 Jan
Diabetes insipidus and anterior pituitary insufficiency as presenting features of Wegener's granulomatosis.
2001 Jan
Adrenocortical dysfunction following etomidate induction in emergency department patients.
2001 Jan
Effect of glucocorticoid therapy on glucocorticoid receptors in children with autoimmune diseases.
2001 Jan
Short-term 17beta-estradiol decreases glucose R(a) but not whole body metabolism during endurance exercise.
2001 Jan
Acute effects of 3,4-methylenedioxymethamphetamine alone and in combination with ethanol on the immune system in humans.
2001 Jan
Reference intervals for glucose, beta-cell polypeptides, and counterregulatory factors during prolonged fasting.
2001 Jan
Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus.
2001 Jan
Hydrocortisone abolishes the angiotensin II-mediated potentiation of endothelin-1 in bovine bronchi.
2001 Jan
Lower baseline plasma cortisol and prolactin together with increased body temperature and higher mCPP-induced cortisol responses in men with pedophilia.
2001 Jan
Neuroendocrine responses to experimentally-induced psychological stress in healthy humans.
2001 Jan
Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior.
2001 Jan
Circadian variation in O6-alkylguanine-DNA alkyltransferase activity in circulating blood mononuclear cells of healthy human subjects.
2001 Jan 1
A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-beta-hydroxysteroid dehydrogenase activity by glycyrrhetic acid.
2001 Jan 1
Ultrarapid opioid detoxification: effects on cardiopulmonary physiology, stress hormones and clinical outcomes.
2001 Jan 1
Neural correlates of maternal separation in rhesus monkeys.
2001 Jan 15
Altered levels of hypothalamic-pituitary-adrenocortical axis hormones in baboons and mice during the course of infection with Schistosoma mansoni.
2001 Jan 15
Crystallization of hydrocortisone acetate: influence of polymers.
2001 Jan 16
Fetal hypothalamus-pituitary-adrenal axis on the road to parturition.
2001 Jan-Feb
Dynamics of circadian fluctuations in serum concentration of cortisol and TNF-alpha soluble receptors in gastrointestinal cancer patients.
2001 Jan-Feb
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Many Hydrocortisone products are used topically https://www.drugs.com/pro/hydrocortisone.html
The initial dosage of CORTEF (Hydrocortisone) Tablets may vary from 20 mg to 240 mg of hydrocortisone per day depending on the specific disease entity being treated.
Route of Administration: Oral
Hydrocortisone concentration-dependently inhibited the current induced by 3 x 10(-5) M ACh with a half maximum inhibitory concentration (IC50) of 2.1 x 10(-4) M (in rats).
Substance Class Chemical
Created
by admin
on Sat Dec 16 20:00:08 GMT 2023
Edited
by admin
on Sat Dec 16 20:00:08 GMT 2023
Record UNII
3X7931PO74
Record Status Validated (UNII)
Record Version
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Name Type Language
HYDROCORTISONE ACETATE
EP   GREEN BOOK   INCI   MART.   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INCI  
Official Name English
HYDROCORTISONE ACETATE COMPONENT OF TERRA-CORTRIL
Common Name English
DRICORT
Brand Name English
HYDROCORTISONE ACETATE [EP IMPURITY]
Common Name English
HYDROCORTISONE ACETATE [ORANGE BOOK]
Common Name English
HYDROCORTISONE ACETATE COMPONENT OF CARMOL HC
Common Name English
HYDROCORTISONE ACETATE COMPONENT OF NEO-CORTEF
Common Name English
HYDROCORTISONI ACETAS [WHO-IP LATIN]
Common Name English
HYDROCORTISONE IMPURITY C [EP IMPURITY]
Common Name English
HYDROCORTISONE ACETATE COMPONENT OF U-CORT
Common Name English
PREDNISOLONE ACETATE IMPURITY A [EP]
Common Name English
HYDROCORTISONE HYDROGEN SUCCINATE IMPURITY B [EP IMPURITY]
Common Name English
EPIFOAM COMPONENT HYDROCORTISONE ACETATE
Common Name English
HYDROCORTISONE ACETATE [MART.]
Common Name English
TERRA-CORTRIL COMPONENT HYDROCORTISONE ACETATE
Common Name English
PRAMOSONE COMPONENT HYDROCORTISONE ACETATE
Common Name English
HYDROCORTISONE ACETATE [USP-RS]
Common Name English
HYDROCORTISONE ACETATE COMPONENT OF PRAMOSONE
Common Name English
HEMSOL-HC
Brand Name English
HYDROCORTISONE ACETATE [USP MONOGRAPH]
Common Name English
CARMOL HC COMPONENT HYDROCORTISONE ACETATE
Common Name English
COR-OTICIN COMPONENT HYDROCORTISONE ACETATE
Common Name English
HYDROCORTISONE ACETATE [INCI]
Common Name English
HYDROCORTISONE ACETATE COMPONENT OF COR-OTICIN
Common Name English
HYDROCORTISONE ACETATE COMPONENT OF EPIFOAM
Common Name English
HYDROCORTISONE 21-ACETATE
MI  
Common Name English
ORABASE HCA
Brand Name English
HYDROCORTISONE ACETATE COMPONENT OF CHLOROMYCETIN HYDROCORTISONE
Common Name English
HYDROCORTISONE ACETATE COMPONENT OF PROCTOFOAM HC
Common Name English
NSC-741
Code English
CORTIFOAM
Brand Name English
NEO-CORTEF COMPONENT HYDROCORTISONE ACETATE
Common Name English
COLY-MYCIN S COMPONENT HYDROCORTISONE ACETATE
Common Name English
HYDROCORTISONE ACETATE [GREEN BOOK]
Common Name English
MICORT-HC
Brand Name English
PREGN-4-ENE-3,20-DIONE, 21-(ACETYLOXY)-11,17-DIHYDROXY-, (11.BETA.)-
Systematic Name English
CHLOROMYCETIN HYDROCORTISONE COMPONENT HYDROCORTISONE ACETATE
Common Name English
HYDROCORTISONE ACETATE [WHO-IP]
Common Name English
Hydrocortisone acetate [WHO-DD]
Common Name English
OPHTHOCORT COMPONENT HYDROCORTISONE ACETATE
Common Name English
HYDROCORTISONE ACETATE [VANDF]
Common Name English
HYDROCORTISONE ACETATE COMPONENT OF COLY-MYCIN S
Common Name English
HYDROCORTISONE 21-ACETATE [MI]
Common Name English
HYDROCORTISONE SODIUM SUCCINATE IMPURITY B [EP IMPURITY]
Common Name English
U-CORT COMPONENT HYDROCORTISONE ACETATE
Common Name English
PROCTOFOAM HC COMPONENT HYDROCORTISONE ACETATE
Common Name English
HYDROCORTISONE ACETATE COMPONENT OF OPHTHOCORT
Common Name English
CORTEF ACETATE
Brand Name English
HYDROCORTISONE ACETATE [EP MONOGRAPH]
Common Name English
Cortisol 21-acetate
Common Name English
HYDROCORTISONE ACETATE [JAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C521
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
FDA ORPHAN DRUG 568616
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
Code System Code Type Description
DRUG CENTRAL
4213
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
DAILYMED
3X7931PO74
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
NSC
741
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
RXCUI
27197
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY RxNorm
CAS
50-03-3
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
RS_ITEM_NUM
1317007
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
MESH
C021650
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
WIKIPEDIA
Hydrocortisone acetate
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
EVMPD
SUB02562MIG
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
HYDROCORTISONE ACETATE
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY Description: A white or almost white, crystalline powder; odourless. Solubility: Practically insoluble in water; slightly soluble in ethanol (~750 g/l) TS; very slightly soluble in ether R. Category: Adrenocortical steroid. Storage: Hydrocortisone acetate should be kept in a well-closed container, protected from light.Additional information: Hydrocortisone acetate melts at about 220?C with decomposition. Definition: Hydrocortisone acetate contains not less than 97.0% and not more than 102.0% of C23H32O6, calculated with reference to the dried substance.
ECHA (EC/EINECS)
200-004-4
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
DRUG BANK
DB14539
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
NCI_THESAURUS
C61785
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
MERCK INDEX
m6094
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY Merck Index
FDA UNII
3X7931PO74
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
SMS_ID
100000092260
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
ChEMBL
CHEMBL1091
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
EPA CompTox
DTXSID0048686
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
CHEBI
17609
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
PUBCHEM
5744
Created by admin on Sat Dec 16 20:00:09 GMT 2023 , Edited by admin on Sat Dec 16 20:00:09 GMT 2023
PRIMARY
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