CHLOROBUTANOL HEMIHYDRATE

US Previously Marketed

First marketed in 1911

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C4H7Cl3O.H2O
Molecular Weight	372.929
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.CC(C)(O)C(Cl)(Cl)Cl.CC(C)(O)C(Cl)(Cl)Cl

InChI

InChIKey=WRWLCXJYIMRJIN-UHFFFAOYSA-N

InChI=1S/2C4H7Cl3O.H2O/c2*1-3(2,8)4(5,6)7;/h2*8H,1-2H3;1H2

HIDE SMILES / InChI

Molecular Formula	C4H7Cl3O
Molecular Weight	177.457
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.athenstaedt.de/download/Product_Information_Chlorobutanol.pdf

Chlorobutanol, or trichloro-2-methyl-2-propanol, is an analgesic and sedative hypnotic in man, and an experimental general anesthetic. It has antibacterial and antifungal properties. It is also used chemical preservative for parenteral drugs. It was found, that chlorobutanol inhibited mammalian Nav 1.2 channels at concentrations less than those used to preserve parenteral solutions. Its mechanism of inhibiting Na channels differs from that of local anesthetics in that it does not show use dependent or state dependent inhibition.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium channel protein type II alpha subunit 27 Target ID: CHEMBL4187 Sources: https://www.isaponline.org/application/files/8214/7034/5599/ISAP_AM_2011_Abstracts_3.pdf	Inhibitor 8504		3.9 mM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: https://www.isaponline.org/application/files/8214/7034/5599/ISAP_AM_2011_Abstracts_3.pdf	Preventing		Not Provided 511	Unknown Approved Use Unknown

T_1/2

Value	Dose	Co-administered	Analyte	Population
10 day EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7159691	600 mg single, oral dose: 600 mg route of administration: Oral experiment type: SINGLE co-administered:		CHLOROBUTANOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
43% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7159691	600 mg single, oral dose: 600 mg route of administration: Oral experiment type: SINGLE co-administered:		CHLOROBUTANOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

Doses

Dose	Population	Adverse events
600 mg single, oral Studied dose Dose: 600 mg Route: oral Route: single Dose: 600 mg Sources: https://pubmed.ncbi.nlm.nih.gov/7159691	healthy, 20-30 Health Status: healthy Age Group: 20-30 Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/7159691	Other AEs: Sedation, Light headedness... Other AEs: Sedation Light headedness Euphoria Sources: https://pubmed.ncbi.nlm.nih.gov/7159691

AEs

AE	Dose	Population
Euphoria	600 mg single, oral Studied dose Dose: 600 mg Route: oral Route: single Dose: 600 mg Sources: https://pubmed.ncbi.nlm.nih.gov/7159691	healthy, 20-30 Health Status: healthy Age Group: 20-30 Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/7159691
Light headedness	600 mg single, oral Studied dose Dose: 600 mg Route: oral Route: single Dose: 600 mg Sources: https://pubmed.ncbi.nlm.nih.gov/7159691	healthy, 20-30 Health Status: healthy Age Group: 20-30 Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/7159691
Sedation	600 mg single, oral Studied dose Dose: 600 mg Route: oral Route: single Dose: 600 mg Sources: https://pubmed.ncbi.nlm.nih.gov/7159691	healthy, 20-30 Health Status: healthy Age Group: 20-30 Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/7159691

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
			inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://www.ema.europa.eu/en/documents/scientific-guideline/chmp-safety-working-partys-response-cmdh-questions-chlorobutanol_en.pdf#page=4 Page: 4.0

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY561036	https://www.001chemical.com/chem/57-15-8
3B Scientific (Wuhan) Corp	3B3-033157	http://www.3bsc.com/index/pro_info.php?id=54421
abcr GmbH	AB539259	http://www.abcr.com/shop/en/AB539259
Accela ChemBio Inc	SY277495	http://www.accelachem.com/cn/search.html?keyword=SY277495&attname=GoodsCode
Achemtek	0104-014893	http://www.achemtek.com/57-15-8
Acorn PharmaTech	ACN-037780	http://www.acornpharmatech.com/
AHH Chemical co.,ltd	MT-26160	http://www.ahhchemical.com/product/MT-26160.html
Alfa Chemistry	28471-22-9	https://www.alfa-chemistry.com/cas_28471-22-9.htm
Allbio Pharm Co., Ltd	AD03646	http://www.allbiopharm.com/product/n/AD03646
Ambeed	A829380	https://www.ambeed.com/products/57-15-8.html
Ark Pharm	AK00061249	http://www.arkpharminc.com/products/57-15-8.html
Aurora Fine Chemicals LLC	K02.100.495	http://online.aurorafinechemicals.com/info?ID=K02.100.495
Aurum Pharmatech LLC	NE21463	http://www.Aurumpharmatech.com/Product/ProductDetails/NE21463
BioSynth	W-105484	https://www.biosynth.com/en/products/chemical-intermediates/basic-intermediates/products/W-105484.html
BLD Pharm	BD52008	http://www.bldpharm.com/products/57-15-8.html
Chem Scene	CS-B1703	http://www.chemscene.com/57-15-8.html
ChemMol	49416380	http://www.chemmol.com/chemmol/49416380.html
ChemMol	99057858	http://www.chemmol.com/chemmol/99057858.html
Chemspace	CSSB00000210252	https://chem-space.com/CSSB00000210252
Clearsynth	CS-EB-00475	https://www.clearsynth.com/en/CSEB00475.html
CSNpharm	CSN21964	https://www.csnpharm.com/products/chlorobutanol.html
Enamine	Z1259084902	https://www.enaminestore.com/catalog/Z1259084902
Finetech	FT-0605936	http://www.finetechnology-ind.com/prod/detail/pub/6001-64-5.html
Finetech	FT-0612881	http://www.finetechnology-ind.com/prod/detail/pub/57-15-8.html
iChemical	EBD2761144	http://www.ichemical.com/products/57-15-8.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
Lab Network	LN00226967	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00226967
mcule	MCULE-7565024869	https://mcule.com/MCULE-7565024869/
MedChem Express	HY-B1263	https://www.medchemexpress.com/chlorobutanol.html
Molcore	MC561036	https://www.molcore.com/product/57-15-8
OlainFarm JSC	Chlorobutanol Hemihydrate	http://www.olainfarm.lv/product/chlorobutanol-hemihydrate/
Otava	2848491	https://search.otavachemicals.com/#!/search?query=2848491&type=code&base=dbb
Selleck Chemicals	S3705	http://www.selleckchem.com/products/chlorobutanol.html
Smolecule	S523513	http://www.smolecule.com/products/s523513
Smolecule	S772652	https://www.smolecule.com/products/s772652
TCI (Tokyo Chemical Industry)	T0386	http://www.tcichemicals.com/eshop/en/us/commodity/T0386/index.html
THE BioTek	bt-264172	https://www.thebiotek.com/product/inhibitors/bt-264172

PubMed

Title	Date	PubMed
[Chlorobutanol poisoning: about a case].	2010-10	20724106
Cytotoxicity of five fluoroquinolone and two nonsteroidal anti-inflammatory benzalkonium chloride-free ophthalmic solutions in four corneoconjunctival cell lines.	2010-09-20	20922036
Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension.	2010-08-09	20714366
High gene expression of inflammatory markers and IL-17A correlates with severity of injection site reactions of Atlantic salmon vaccinated with oil-adjuvanted vaccines.	2010-05-27	20507624
The world's richest tadpole communities show functional redundancy and low functional diversity: ecological data on Madagascar's stream-dwelling amphibian larvae.	2010-05-12	20459864
Interactions at human ether-à-go-go-related gene channels.	2010-04	20071423
Modification of cell wall properties in lettuce improves shelf life.	2010-02	20179011
Evaluation of acute corneal barrier change induced by topically applied preservatives using corneal transepithelial electric resistance in vivo.	2010-01	19770721
Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization.	2009-12-17	20015408
Therapeutic approaches to cerebral vasospasm complicating ruptured aneurysm.	2009-11-16	21577350
Allergy to ophthalmic preservatives.	2009-10	19697451
Randomized, placebo-controlled evaluation of chlorobutanol, potassium carbonate, and irrigation in cerumen removal.	2009-08	19746751
Methadone-associated Q-T interval prolongation and torsades de pointes.	2009-05-01	19386945
A Freshwater clam (Corbicula fluminea) extract reduces cholesterol level and hepatic lipids in normal rats and xenobiotics-induced hypercholesterolemic rats.	2009-04-22	19275237
In vitro permeation of desmopressin across rabbit nasal mucosa from liquid nasal sprays: the enhancing effect of potassium sorbate.	2009-04-11	19162181
GC determination of acetone, acetaldehyde, ethanol, and methanol in biological matrices and cell culture.	2009-04	19406012
Reichardt's dye and its reactions with the alkylating agents 4-chloro-1-butanol, ethyl methanesulfonate, 1-bromobutane and Fast Red B - a potentially useful reagent for the detection of genotoxic impurities in pharmaceuticals.	2009-04	19298702
Comparative toxicity of preservatives on immortalized corneal and conjunctival epithelial cells.	2009-04	19284328
Atlantic salmon eggs favour sperm in competition that have similar major histocompatibility alleles.	2009-02-07	18854296
Minimally invasive strabismus surgery (MISS) for inferior obliquus recession.	2009-02	18958486
Regeneration of the radial nerve cord in the sea cucumber Holothuria glaberrima.	2009-01-06	19126208
Ocular preservatives: associated risks and newer options.	2009	19505226
Minimally invasive strabismus surgery for horizontal rectus muscle reoperations.	2008-12	18782805
DNA damage in preserved specimens and tissue samples: a molecular assessment.	2008-10-23	18947416
Cytotoxicity of ophthalmic solutions with and without preservatives to human corneal endothelial cells, epithelial cells and conjunctival epithelial cells.	2008-08	18954319
[Efficacy of an antiseptic dialysis of purulent wounds in the dentofacial region with hyvalix].	2008-04-18	18416174
Ototoxicity of triethanolamine polypeptide (cerumenex) in the chinchilla.	2008-03	18090863
Development and evaluation of a chloramphenicol hypertonic ophthalmic solution.	2008-01	20390083
Common cellular events occur during wound healing and organ regeneration in the sea cucumber Holothuria glaberrima.	2007-10-18	17945004
Equimolar mixture of 2,2,2-trifluoroethanol and 4-chloro-1-butanol is a stronger inducer of molten globule state: isothermal titration calorimetric and spectroscopic studies.	2007-10	17786546
[The treatment of hyperemesis gravidarum with chlorobutanol-caffeine rectal suppositories in Denmark: practice and evidence].	2007-05-28	17553397
Medication administered to children from 0 to 7.5 years in the Avon Longitudinal Study of Parents and Children (ALSPAC).	2007-02	17200835
Development and validation of a stability-indicating analytical method for the quantitation of oxytocin in pharmaceutical dosage forms.	2007-01-04	16920323
[Contact allergy to triethanolamine in ear drops and shampoo].	2007-01	17384563
Vitamin C. Biosynthesis, recycling and degradation in mammals.	2007-01	17222174
Conjunctival provocation test for the diagnosis of ocular hypersensitivity to chlorobutanol.	2007-01	17198021
Effect of ophthalmic solution components on acrylic intraocular lenses.	2007-01	17189806
Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage.	2007	17705883
Are multidose over-the-counter artificial tears adequately preserved?	2006-05	16670481
Glucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver.	2006-04	16689937
An efficient synthesis of a dual PPAR alpha/gamma agonist and the formation of a sterically congested alpha-aryloxyisobutyric acid via a Bargellini reaction.	2005-10-14	16209608
Cerumen removal products.	2005-10-06	16202844
Preventing exposure keratopathy in the critically ill: a prospective study comparing eye care regimes.	2005-08	16024871
Allergic contact dermatitis from triethanolamine polypeptide oleate condensate in eardrops and shampoo.	2005-04	15860001
Application of a capillary electrophoresis method for simultaneous determination of preservatives in pharmaceutical formulations.	2005-02	15754820
Assessment of corneal epitheliopathy in the critically ill.	2005-02	15565358
Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.	2004-11	15472097
Randomized, placebo-controlled evaluation of Cerumenex and Murine earwax removal products.	2004-10	15492164
Chronic tinnitus resulting from cerumen removal procedures.	2004	15379348
Is ketamine or its preservative responsible for neurotoxicity in the rabbit?	1993-01	8424543

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

It was examined chlorobutanol effect on on exocrine response and intracellular Ca2+ dynamics in isolated pancreatic acini of the rat. Chlorobutanol (1 mg ml-1) markedly inhibited the secretory response to cholecystokinin octapeptide (CCK-8), carbamylcholine chloride (carbachol), or sodium fluoride, a direct G-protein activator. However, chlorobutanol itself induced a maximal release of amylase when the dose was increased to 4 mg ml-1. Chlorobutanol inhibited 13 pM [125I]-CCK-8 or 0.5 nM [3H]-methylscopolamine chloride binding to the acinar cells in a dose-dependent manner. These results indicate that chlorobutanol produces discernible pharmacological effects on the secretory response in rat pancreatic acinar cells through changes in the Ca2+ dynamics.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:08:34 GMT 2025` Edited by `admin` on `Mon Mar 31 18:08:34 GMT 2025`
Record UNII	3X4P6271OX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLOROBUTANOL HEMIHYDRATE

Common Name

English

CHLOROBUTANOL HEMIHYDRATE [WHO-IP]

Preferred Name

English

2-PROPANOL, 1,1,1-TRICHLORO-2-METHYL-, HEMIHYDRATE

Common Name

English

1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

Common Name

English

CHLOROBUTANOL HEMIHYDRATE [EP MONOGRAPH]

Common Name

English

CHLOROBUTANOL HEMIHYDRATE [II]

Common Name

English

NSC-760101

Code

English

Chlorobutanol hemihydrate [WHO-DD]

Common Name

English

Code System Code Type Description

SMS_ID

100000092147