HYDROPRENE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H30O2
Molecular Weight	266.4189
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)\C=C(C)\C=C\CC(C)CCCC(C)C

InChI

InChIKey=FYQGBXGJFWXIPP-UEVLXMDPSA-N

InChI=1S/C17H30O2/c1-6-19-17(18)13-16(5)12-8-11-15(4)10-7-9-14(2)3/h8,12-15H,6-7,9-11H2,1-5H3/b12-8+,16-13+

HIDE SMILES / InChI

Molecular Formula	C17H30O2
Molecular Weight	266.4189
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	2
Optical Activity	( + / - )

Description
Sources: http://npic.orst.edu/factsheets/hydropregen.pdf
Curator's Comment: description was created based on several sources, including: DOI: 10.1016/j.cropro.2006.01.014 http://pmep.cce.cornell.edu/profiles/insect-mite/fenitrothion-methylpara/hydroprene/(S)-Hydroprene_tol_597.html

Hydroprene is a synthetic version of the insect hormone that regulates growth and development. Hydroprene can be considered as an alternative to conventional insecticides because of its specific activity against immature insect stages, low persistence in the environment, and virtually non-toxic effects on mammals. Hydroprene products are used on a variety of indoor sites including homes, offices, warehouses, restaurants, hospitals, and greenhouses.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
CYP4C7 (Corpora allata cytochrome P450) 1 Target ID: CYP4C7 (Corpora allata cytochrome P450) Sources: https://www.ncbi.nlm.nih.gov/pubmed/10818249	Activator 1430
Insect juvenile hormones 2 Target ID: Insect juvenile hormones Sources: doi: 10.1016/j.cropro.2006.01.014	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Flea infestations 12 Sources: https://www.americanpest.net/docs/msds/gentrol-igr-label.pdf https://www.ncbi.nlm.nih.gov/pubmed/8756312	Curative		Approved 8429	GENCOR Approved Use Hydroprene disrupts the normal life cycle of fleas, thus killing these insects Launch Date 1984
Mite infestation 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8510113	Curative		Basic research	GENCOR Approved Use Unknown Launch Date 1984

PubMed

Title	Date	PubMed
Population growth of Dermatophagoides farinae Hughes (Acari: Epidermoptidae) suppressed by methoprene and hydroprene.	1993 May	8510113
Terpenoid omega-hydroxylase (CYP4C7) messenger RNA levels in the corpora allata: a marker for ovarian control of juvenile hormone synthesis in Diploptera punctata.	2000 Aug 1	10818249

Patents

Sample Use Guides

In Vivo Use Guide

Treatments with 10% hydroprene resulted in the maximum growth reduction of house dust mite at both 30 d (94%) and 90 d (97%)

Route of Administration: Other

In Vitro Use Guide

53% of the hydroprene (4.54 uCi/uM in 5 uL of ethanol) was metabolized after 30 min of incubation with isolated (3.6 x 10^6 per ml) hepatocytes.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:16:55 GMT 2023` Edited by `admin` on `Sat Dec 16 05:16:55 GMT 2023`
Record UNII	3SS174B1Y9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HYDROPRENE

Common Name

English

ETHYL (2E,4E)-3,7,11-TRIMETHYLDODECA-2,4-DIENOATE

Systematic Name

English

ZR-512

Code

English

SHA-486300

Code

English

GENCOR

Brand Name

English

OMS-1696

Code

English

DL-ETHYL 3,7,11-TRIMETHYL-TRANS-TRANS-2,4-DODECADIENOATE

Common Name

English

HYDROPRENE, (±)-

Common Name

English

GENTROL

Brand Name

English

HYDROPRENE [ISO]

Common Name

English

2,4-DODECADIENOIC ACID, 3,7,11-TRIMETHYL-, ETHYL ESTER, (2E,4E)-

Common Name

English

HYDROPRENE [MI]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

486300