DIHYDRALAZINE SULFATE, HYDRATED

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C8H10N6.5H2O.2H2O4S
Molecular Weight	666.644
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DIHYDRALAZINE SULFATE, HYDRATED

Structure Search

SMILES

O.O.O.O.O.OS(O)(=O)=O.OS(O)(=O)=O.NNC1=C2C=CC=CC2=C(NN)N=N1.NNC3=C4C=CC=CC4=C(NN)N=N3

InChI

InChIKey=JOPVPUGEMVRMOY-UHFFFAOYSA-N

InChI=1S/2C8H10N6.2H2O4S.5H2O/c2*9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7;2*1-5(2,3)4;;;;;/h2*1-4H,9-10H2,(H,11,13)(H,12,14);2*(H2,1,2,3,4);5*1H2

HIDE SMILES / InChI

Molecular Formula	C8H10N6
Molecular Weight	190.2052
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O4S
Molecular Weight	98.078
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6477782

Dihydralazine is a compound with antihypertensive properties and is in clinical trials, where is studied its effect on kidney function and hormones in healthy individuals.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
High blood pressure 6 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6477782	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Effects of acute hypotension and hypertension on serum TSH concentrations in male rats.	1979 Oct	525373
[Rare liver damage caused by an antihypertensive and anti-arrhythmic agents].	1980 Apr 1	7405322
Side-effects with long-term labetalol: an open study of 251 patients in a single centre.	1983	6844370
Action of vasodilating drugs on small and large arteries of hypertensive patients.	1983 Jul-Aug	6193361
Mode of antihypertensive action of nitrendipine.	1984	6085384
Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion.	1988 May	3383316
Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.	1996 Oct-Nov	8902272
[Hypertensive disorders in pregnancy].	2001 Feb 15	11253286
Plasma volume and blood pressure regulation in hypertensive pregnancy.	2004 Jul	15201535
Protein adduct-trapping by hydrazinophthalazine drugs: mechanisms of cytoprotection against acrolein-mediated toxicity.	2004 Mar	14978244
Flow-injection chemiluminescence determination of dihydralazine sulfate based on hexacyanoferrate(III) oxidation sensitized by eosin Y.	2004 Oct 8	18969628
3,6-Bis(2-pyridyl)di-1,2,4-triazolo[3,4-a:4',3'-c]phthalazine.	2004 Sep	15345850
Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.	2005	15762770
Isolated sarcoid granulomatous interstitial nephritis responding to infliximab therapy.	2005 Feb	15685521
Antihypertensive therapy in patients with pre-eclampsia: A prospective randomised multicentre study comparing dihydralazine with urapidil.	2006 Aug	16253414
[Hypertension in pregnancy].	2006 Mar	16722158
Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation?	2007 Dec	17823234
Method development for dihydralazine with HPLC-MS/MS--an old but tricky substance in human plasma.	2007 Jan 17	16950590
Nitric oxide-deficiency regulates hepatic heme oxygenase-1.	2008 Feb	17999922
Maternal and fetal hemodynamic effects induced by nitric oxide donors and plasma volume expansion in pregnancies with gestational hypertension complicated by intrauterine growth restriction with absent end-diastolic flow in the umbilical artery.	2008 Jan	18098350
Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development.	2009	19754423
Hemodynamic, morphometric and autonomic patterns in hypertensive rats - Renin-Angiotensin system modulation.	2010	20126350
[Drugs during preeclampsia. Fetal risks and pharmacology].	2010 Apr	20347563
Flow-injection chemiluminescence determination of dihydralazine sulfate in serum using luminol and diperiodatocuprate (III) system.	2010 Jan	19910243
Autoimmune hepatitis triggered by nitrofurantoin: a case series.	2010 Sep 23	20863377
A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.	2014 Jan	24085192

Patents

Sample Use Guides

In Vivo Use Guide

The influence of a pure afterload reduction on systolic time intervals and various echocardiographic indices was assessed in six healthy volunteers, who underwent a single blind placebo controlled trial of three regimens of intravenous dihydralazine (6.25, 12.5, and 25.0 mg).

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:37:19 GMT 2023` Edited by `admin` on `Fri Dec 15 18:37:19 GMT 2023`
Record UNII	3RYP614N6L
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DIHYDRALAZINE SULFATE, HYDRATED

Common Name

English

1,4-DIHYDRAZINOPHTHALAZINIUM MONOSULFATE HYDRATE

Systematic Name

English

DIHYDRALAZINE SULFATE, HYDRATED [EP MONOGRAPH]

Common Name

English

PHTHALAZINE, 1,4-DIHYDRAZINYL-, COMPD. WITH SULFURIC ACID, HYDRATE (1:1:2.5)

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID30220456