3-METHYLGLUTARIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H10O4
Molecular Weight	146.1412
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CC(O)=O)CC(O)=O

InChI

InChIKey=XJMMNTGIMDZPMU-UHFFFAOYSA-N

InChI=1S/C6H10O4/c1-4(2-5(7)8)3-6(9)10/h4H,2-3H2,1H3,(H,7,8)(H,9,10)

HIDE SMILES / InChI

Molecular Formula	C6H10O4
Molecular Weight	146.1412
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Studies on a child suspected of having a dficiency in 3-hydroxy-3-methylglutaryl-Co A lyase.	1979 Jul 2	509721
Inherited 3-methylglutaconic aciduria in two brothers--another defect of leucine metabolism.	1982 Oct	6181239
Behr's syndrome and 3-methylglutaconic aciduria.	1992 Oct 15	1384336
Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.	1994 Jun	8087979
Type III 3-methylglutaconic aciduria (optic atrophy plus syndrome, or Costeff optic atrophy syndrome): identification of the OPA3 gene and its founder mutation in Iraqi Jews.	2001 Dec	11668429
Mitochondrial DNA depletion associated with partial complex II and IV deficiencies and 3-methylglutaconic aciduria.	2001 Feb	11292221
3-Hydroxy-3-methylglutaric aciduria in an Italian patient is caused by a new nonsense mutation in the HMGCL gene.	2001 Jul	11461194
3-Methylglutaconic aciduria type III in a non-Iraqi-Jewish kindred: clinical and molecular findings.	2002 Jul	12126933
3-methyglutaconic aciduria in a Chinese patient with glycogen storage disease Ib.	2003	14707520
Vitamin E analogues as inducers of apoptosis: structure-function relation.	2003 Jun 16	12799642
A new sensitive isotropic-anisotropic separation experiment-SPEED MAS.	2004 Jun	15140441
NMR spectroscopic studies on the late onset form of 3-methylglutaconic aciduria type I and other defects in leucine metabolism.	2006 Apr	16541463
3-Methylglutaric acid as a 13C solid-state NMR standard.	2006 Oct	16887343
3-methylglutaconic aciduria type 4 manifesting as Leigh syndrome in 2 siblings.	2007 Feb	17621487
Costeff optic atrophy syndrome: new clinical case and novel molecular findings.	2008 Dec	18985435
Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats.	2008 Mar 12	18261750
Striatum is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as compared to liver.	2009 Jun	19460629
Inherited mitochondrial optic neuropathies.	2009 Mar	19001017
OPA3, mutated in 3-methylglutaconic aciduria type III, encodes two transcripts targeted primarily to mitochondria.	2010 Jun	20350831

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:39:02 GMT 2023` Edited by `admin` on `Fri Dec 15 18:39:02 GMT 2023`
Record UNII	3Q0P190C7B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

3-METHYLGLUTARIC ACID

Systematic Name

English

NSC-14870

Code

English

3-METHYLPENTANEDIOIC ACID

Systematic Name

English

GLUTARIC ACID, .BETA.-METHYL-

Common Name

English

PENTANEDIOIC ACID, 3-METHYL-

Common Name

English

.BETA.-METHYLGLUTARIC ACID

Common Name

English

GLUTARIC ACID, 3-METHYL-

Common Name

English

Code System Code Type Description

NSC

14870