BAVUNALIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 01:29:50 GMT 2025` Edited by `admin` on `Wed Apr 02 01:29:50 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	3PT70X17VS
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

XMAB22841

Preferred Name

English

BAVUNALIMAB

Official Name

English

IMMUNOGLOBULIN, ANTI-(HUMAN CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 4) (HUMAN-MUS MUSCULUS MONOCLONAL XMAB22841 SINGLE-CHAIN VARIABLE FRAGMENT VH-LINKER-VL) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN .GAMMA.1-CHAIN C-REGION C-TERMINAL FRAGMENT), (257

Common Name

English

ANTI-CTLA-4/LAG-3 BISPECIFIC ANTIBODY XMAB22841

Common Name

English

XMAB-22841

Code

English

Bavunalimab [WHO-DD]

Common Name

English

bavunalimab [INN]

Common Name

English

PAVUNALIMAB

Common Name

English

BAVUNALIMAB [USAN]

Common Name

English

IMMUNOGLOBULIN HALF-IG G1-KAPPA/SCFV-H-CH2-CH3, ANTI-(HOMO SAPIENS LAG3 (LYMPHOCYTE ACTIVATING 3, LYMPHOCYTE-ACTIVATION 3, CD223)) AND ANTI-(HOMO SAPIENS CTLA4 (CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 4, CD152)), MONOCLONAL ANTIBODY, BISPECIFIC; GAMMA1

Common Name

English

Code System Code Type Description

INN

11465

Created by admin on Wed Apr 02 01:29:50 GMT 2025 , Edited by admin on Wed Apr 02 01:29:50 GMT 2025

PRIMARY

NCI_THESAURUS

C159530

Created by admin on Wed Apr 02 01:29:50 GMT 2025 , Edited by admin on Wed Apr 02 01:29:50 GMT 2025

PRIMARY

SMS_ID

300000028011

Created by admin on Wed Apr 02 01:29:50 GMT 2025 , Edited by admin on Wed Apr 02 01:29:50 GMT 2025

PRIMARY

CAS

2250088-66-3

Created by admin on Wed Apr 02 01:29:50 GMT 2025 , Edited by admin on Wed Apr 02 01:29:50 GMT 2025

NO STRUCTURE GIVEN

USAN

JK-27

Created by admin on Wed Apr 02 01:29:50 GMT 2025 , Edited by admin on Wed Apr 02 01:29:50 GMT 2025

PRIMARY

FDA UNII

3PT70X17VS

Created by admin on Wed Apr 02 01:29:50 GMT 2025 , Edited by admin on Wed Apr 02 01:29:50 GMT 2025

PRIMARY

CAS

2329669-78-3

Created by admin on Wed Apr 02 01:29:50 GMT 2025 , Edited by admin on Wed Apr 02 01:29:50 GMT 2025

PRIMARY

From	To
1_260	2_233
1_257	2_230
2_224	3_218
3_138	3_198
3_23	3_92
2_370	2_428
2_264	2_324
2_148	2_204
2_22	2_98
1_397	1_455
1_291	1_351
1_161	1_227
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_327

Related Record Type Details


					KYU4T5WAI2

CYTOTOXIC T-LYMPHOCYTE PROTEIN 4

TARGET -> INHIBITOR

Amount:


					AK0JDV1ZK5

LYMPHOCYTE ACTIVATION GENE 3 PROTEIN

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					3PT70X17VS

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_477] [2_450]			Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL