KP-1461

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H28N4O6
Molecular Weight	372.4167
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCOC(=O)NC1=NC(=O)N(CN1)[C@H]2C[C@H](O)[C@@H](CO)O2

InChI

InChIKey=SZWIAFVYPPMZML-YNEHKIRRSA-N

InChI=1S/C16H28N4O6/c1-2-3-4-5-6-7-25-16(24)19-14-17-10-20(15(23)18-14)13-8-11(22)12(9-21)26-13/h11-13,21-22H,2-10H2,1H3,(H2,17,18,19,23,24)/t11-,12+,13+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H28N4O6
Molecular Weight	372.4167
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67522536 | https://aidsinfo.nih.gov/drugs/554/kp-1461/0/patient | https://www.ncbi.nlm.nih.gov/pubmed/15890415

KP-1461 is a prodrug of KP-1212, an antiviral agent developed for the treatment of human immunodeficiency virus (HIV) infection. KP-1212 induces an increase in the HIV mutation rate thus leading to viral ablation.

Originator

Approval Year

PubMed

Title	Date	PubMed
Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461.	2011 Jan 14	21264288
Safety, Tolerability, and Pharmacokinetics of KP-1461 in Phase I Clinical Studies: A Single Oral Dose Study in Non-HIV-Infected Adults, and a 14-Day Dose-Escalating Study in Highly Antiretroviral-Experienced HIV-Infected Adults.	2011 Jul-Aug	21593403
Safety, tolerability, and efficacy of KP-1461 as monotherapy for 124 days in antiretroviral-experienced, HIV type 1-infected subjects.	2013 Feb	22738014

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:58:23 UTC 2023` Edited by `admin` on `Fri Dec 15 18:58:23 UTC 2023`
Record UNII	3PEN569TJP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

KP-1461

Common Name

English

KP 1461

Common Name

English

CARBAMIC ACID, (5-(2-DEOXY-.BETA.-D-ERYTHRO-PENTOFURANOSYL)-1,4,5,6-TETRAHYDRO-4-OXO-1,3,5-TRIAZIN-2-YL)-, HEPTYL ESTER

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID101112194