CYTHIOATE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H12NO5PS2
Molecular Weight	297.288
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COP(=S)(OC)OC1=CC=C(C=C1)S(N)(=O)=O

InChI

InChIKey=BSBSDQUZDZXGFN-UHFFFAOYSA-N

InChI=1S/C8H12NO5PS2/c1-12-15(16,13-2)14-7-3-5-8(6-4-7)17(9,10)11/h3-6H,1-2H3,(H2,9,10,11)

HIDE SMILES / InChI

Molecular Formula	C8H12NO5PS2
Molecular Weight	297.288
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Cythioate is an organothiophosphate chemical used as an insecticide and anthelmintic. Cythioate is a cholinesterase inhibitor. Marketed under the trade names Cyflee and Proban, Cythioate is indicated for the control of ticks, fleas, and demodectic mange in dogs, and fleas in cats.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) 1	Inhibitor 8,297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Demodicosis 1	Curative		Approved 8,429	Proban

PubMed

Show entries

Title	Date	PubMed
Motor unit irritability in Beagles Before and after exposure to cholinesterase inhibitors.	1979 Jun	89824
Comparative speed of kill between nitenpyram, fipronil, imidacloprid, selamectin and cythioate against adult Ctenocephalides felis (Bouché) on cats and dogs.	2003 Mar 10	12591200

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Patents

Sample Use Guides

In Vivo Use Guide

Dogs: 15 milligrams cythioate per 10 pounds of body weight every third day or twice a week.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical
Record UNII	3OOH7Q4333
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

CYTHIOATE

Common Name

English

O-(4-(AMINOSULFONYL)PHENYL) O,O-DIMETHYL PHOSPHOROTHIOATE

Systematic Name

English

CYTHIOATE [GREEN BOOK]

Common Name

English

O,O-DIMETHYL O-(4-SULFAMOYLPHENYL) PHOSPHOROTHIOATE

Systematic Name

English

NSC-310287

Code

English

Showing 1 to 5 of 8 entries

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Show entries

Classification Tree

Code System

Code

Organophosphorous compounds

WHO-VATC

QP53BB01

EPA PESTICIDE

EPA PESTICIDE CODE

59501

Anti-Infective Agent

NCI_THESAURUS

C276

PART 520 ORAL DOSAGE FORM NEW ANIMAL DRUGS

CFR

21 CFR 520.531

Organophosphorous compounds

WHO-VATC

QP53AF10

Showing 1 to 5 of 6 entries

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Show entries

Code System

Code

Type

Description

SMS_ID

300000023791

PRIMARY

CAS

115-93-5

PRIMARY

ALANWOOD

cythioate

PRIMARY

PUBCHEM

8293

PRIMARY

EPA CompTox

DTXSID8041828

PRIMARY

Showing 1 to 5 of 14 entries

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