CYTHIOATE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H12NO5PS2
Molecular Weight	297.288
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COP(=S)(OC)OC1=CC=C(C=C1)S(N)(=O)=O

InChI

InChIKey=BSBSDQUZDZXGFN-UHFFFAOYSA-N

InChI=1S/C8H12NO5PS2/c1-12-15(16,13-2)14-7-3-5-8(6-4-7)17(9,10)11/h3-6H,1-2H3,(H2,9,10,11)

HIDE SMILES / InChI

Molecular Formula	C8H12NO5PS2
Molecular Weight	297.288
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.law.cornell.edu/cfr/text/21/520.530 | https://www.drugs.com/international/cythioate.html | https://www.bestpricepets.com/products/Proban-Tablets-%252d-100%27s.html#

Cythioate is an organothiophosphate chemical used as an insecticide and anthelmintic. Cythioate is a cholinesterase inhibitor. Marketed under the trade names Cyflee and Proban, Cythioate is indicated for the control of ticks, fleas, and demodectic mange in dogs, and fleas in cats.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) 1 Target ID: CHEMBL2111475 Sources: https://www.ncbi.nlm.nih.gov/pubmed/992748 \| http://www.ijp-online.com/article.asp?issn=0253-7613;year=1976;volume=8;issue=1;spage=13;epage=15;aulast=Doval;type=0	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Demodicosis 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12591200 https://www.ncbi.nlm.nih.gov/pubmed/11812623 https://www.ncbi.nlm.nih.gov/pubmed/5393090	Curative		Approved 8429	Proban Approved Use Proban® is an oral medication for the control of ticks, fleas, and demodectic mange in dogs, and fleas in cats. Launch Date 1966

PubMed

Title	Date	PubMed
Motor unit irritability in Beagles Before and after exposure to cholinesterase inhibitors.	1979 Jun	89824
Comparative speed of kill between nitenpyram, fipronil, imidacloprid, selamectin and cythioate against adult Ctenocephalides felis (Bouché) on cats and dogs.	2003 Mar 10	12591200

Patents

Sample Use Guides

In Vivo Use Guide

Dogs: 15 milligrams cythioate per 10 pounds of body weight every third day or twice a week.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:08:18 GMT 2023` Edited by `admin` on `Fri Dec 15 15:08:18 GMT 2023`
Record UNII	3OOH7Q4333
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CYTHIOATE

Common Name

English

O-(4-(AMINOSULFONYL)PHENYL) O,O-DIMETHYL PHOSPHOROTHIOATE

Systematic Name

English

CYTHIOATE [GREEN BOOK]

Common Name

English

O,O-DIMETHYL O-(4-SULFAMOYLPHENYL) PHOSPHOROTHIOATE

Systematic Name

English

NSC-310287

Code

English

O,O-DIMETHYL O-4-SULFAMOYLPHENYL PHOSPHOROTHIOATE

Systematic Name

English

CYTHIOATE [MI]

Common Name

English

CYTHIOATE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QP53BB01