SOMAN

Details

Stereochemistry	MIXED
Molecular Formula	C7H16FO2P
Molecular Weight	182.1729
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(OP(C)(F)=O)C(C)(C)C

InChI

InChIKey=GRXKLBBBQUKJJZ-UHFFFAOYSA-N

InChI=1S/C7H16FO2P/c1-6(7(2,3)4)10-11(5,8)9/h6H,1-5H3

HIDE SMILES / InChI

Molecular Formula	C7H16FO2P
Molecular Weight	182.1729
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

PubMed

Title	Date	PubMed
[Scientific principles of sanitary and hygienic basis of chemical weapons demolishment].	2002	12593148
Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents.	2002	12475193
Measurements of chemical warfare agent degradation products using an electrophoresis microchip with contactless conductivity detector.	2002 Dec 1	12498212
Vesicants and nerve agents in chemical warfare. Decontamination and treatment strategies for a changed world.	2002 Oct	12400151
A review of nerve agent exposure for the critical care physician.	2002 Oct	12394966
Physostigmine and hyoscine improves protection against the lethal and incapacitating effects of nerve agent poisoning in the guinea-pig.	2002 Sep	12387361
The ratio of serum paraoxonase/arylesterase activity using an improved assay for arylesterase activity to discriminate PON1(R192) from PON1(Q192).	2003	15037822
Inhalation apparatus for generating sarin and soman toxic vapors.	2003	14965166
A comparison of the neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in soman-poisoned rats.	2003	14677718
Nimodipine affects the microcirculation and modulates the vascular effects of acetylcholinesterase inhibition.	2003	14649325
Alterations in brain glutathione homeostasis induced by the nerve gas soman.	2003	12835122
Hydrolytic properties of per (3,6-anhydro, 2-O-carboxymethyl) alpha cyclodextrin complexes of Ce (III) and Eu (III): application to soman (GD) degradation.	2003 Apr	12806827
Field verification of Test-mate ChE.	2003 Apr	12733677
Control of nerve agent-induced seizures is critical for neuroprotection and survival.	2003 Apr 15	12691725
Organophosphate nerve agent toxicity in Hydra attenuata.	2003 Aug	12924922
Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase.	2003 Aug 1	12907237
Pharmacokinetics of intramuscularly administered biperiden in guinea pigs challenged with soman.	2003 Feb	12643036
Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors.	2003 Jan	12490599
Effects of pretreatment with 8018 on the toxicokinetics of soman in rabbits and distribution in mice.	2003 Jul 11	12818357
Chemical warfare agents: their past and continuing threat and evolving therapies. Part I of II.	2003 Jul-Aug	14673274
Neuroprotective effects of currently used antidotes in tabun-poisoned rats.	2003 Jun	12787257
Pharmacological agents, hippocampal EEG, and anticonvulsant effects on soman-induced seizures in rats.	2003 Jun	12782101
Human carboxylesterase 1: from drug metabolism to drug discovery.	2003 Jun	12773168
Partial adenosine A(1) receptor agonists inhibit sarin-induced epileptiform activity in the hippocampal slice.	2003 Jun 20	12818696
Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioural effects of organophosphates in the common marmoset (Callithrix jacchus).	2003 Mar	12589520
Clinical trials. New rule triggers debate over best way to test drugs.	2003 Mar 14	12637715
Effects of pretreatment with verapamil on the toxicokinetics of soman in rabbits and distribution in mouse brain and diaphragm.	2003 Mar 3	12565199
The effect of acetylcholinesterase-inhibition on depolarization-induced GABA release from rat striatal slices.	2003 Mar 3	12499118
Gulf war syndrome: narrowing the possibilities.	2003 May	12849177
Take your pyridostigmine: that's an (ethical?) order!	2003 May	12849173
Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme.	2003 May	12679808
Putative role of proteolysis and inflammatory response in the toxicity of nerve and blister chemical warfare agents: implications for multi-threat medical countermeasures.	2003 May-Jun	12794939
Early changes in MAP2 protein in the rat hippocampus following soman intoxication.	2003 Nov	14582377
DNA fragmentation in leukocytes following subacute low-dose nerve agent exposure.	2003 Oct	14618272
Central neuro-inflammatory gene response following soman exposure in the rat.	2003 Oct 9	12951190
A comparison of the decontamination efficacy of foam-making blends based on cationic and nonionic tensides against organophosphorus compounds determined in vitro and in vivo.	2003 Sep	14580011
Anticholinergic and antiglutamatergic agents protect against soman-induced brain damage and cognitive dysfunction.	2003 Sep	12832655
A fluorogenic substrate for detection of organophosphatase activity.	2004 Apr 1	15033522
A guinea pig hippocampal slice model of organophosphate-induced seizure activity.	2004 Aug	15031302
The application of the fluoride reactivation process to the detection of sarin and soman nerve agent exposures in biological samples.	2004 Feb	15038250
Function of plasma and microsomal enzymes in soman toxicity.	2004 Feb	15038249
Effects of fosphenytoin on nerve agent-induced status epilepticus.	2004 Feb	15038246
Antagonism of anticholinesterase (DFP) toxicity by donepezil plus scopolamine: a preliminary study.	2004 Feb	14751462
Estimation of the upper limit of human butyrylcholinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model.	2004 Feb	14600276
The effect of fluoride on the scavenging of organophosphates by human butyrylcholinesterase in buffer solutions and human plasma.	2004 Jan 1	14728983
Cognitive side effects in rats caused by pharmacological agents used to prevent soman-induced lethality.	2004 Jan 12	14729117
Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase.	2004 Jun	14985944
Inhalational exposure to nerve agents.	2004 Mar	15062227
Organophosphate-induced convulsions and prevention of neuropathological damages.	2004 Mar 1	15036754
Periodic orbit analysis reveals subtle effects of atropine on epileptiform activity in the guinea-pig hippocampal slice.	2004 Mar 11	15003280

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:13:47 GMT 2023` Edited by `admin` on `Sat Dec 16 08:13:47 GMT 2023`
Record UNII	3OF3WXB67Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SOMAN

Systematic Name

English

METHYL PINACOLYL PHOSPHONOFLUORIDATE

Common Name

English

SOMAN [MI]

Common Name

English

GD (CHEMICAL WARFARE AGENT)

Common Name

English

METHYL PINACOLYLOXY PHOSPHORYLFLUORIDE

Systematic Name

English

3,3-DIMETHYL-N-BUT-2-YL METHYLPHOSPHONOFLUORIDATE

Common Name

English

PINACOLYL METHYLFLUOROPHOSPHONATE

Common Name

English

PHOSPHONOFLUORIDIC ACID, P-METHYL-, 1,2,2-TRIMETHYLPROPYL ESTER

Systematic Name

English

PMFP

Common Name

English

1,2,2-TRIMETHYLPROPYL METHYLPHOSPHONOFLUORIDATE

Systematic Name

English

PINACOLOXYMETHYLPHOSPHORYL FLUORIDE

Common Name

English

Code System Code Type Description

HSDB

6764