Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C14H20N4O.ClH |
| Molecular Weight | 296.796 |
| Optical Activity | ( - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.C(C1CONC(=N1)C2=CC=CN=C2)N3CCCCC3
InChI
InChIKey=AVKGCNAECFSXHH-UHFFFAOYSA-N
InChI=1S/C14H20N4O.ClH/c1-2-7-18(8-3-1)10-13-11-19-17-14(16-13)12-5-4-6-15-9-12;/h4-6,9,13H,1-3,7-8,10-11H2,(H,16,17);1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C14H20N4O |
| Molecular Weight | 260.3348 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
IROXANADINE, a pyridine derivative, is under development for the treatment of atherosclerosis and the complications of atherosclerosis such as ischaemic heart disease, peripheral arterial disease, and restenosis. It induces phosphorylation of p38 stress-activated protein kinase, which plays an important role in endothelial cells (EC) homeostasis. EC function plays a central role in vascular diseases.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacologically activated migration of aortic endothelial cells is mediated through p38 SAPK. | 2002 Jun |
|
| Pharmacological attenuation of apoptosis in reoxygenated endothelial cells. | 2004 Dec |
|
| Reverse regulation of endothelial cells and myointimal hyperplasia on cell proliferation by a heatshock protein-coinducer after hypoxia. | 2008 Mar |
|
| Restenosis and therapy. | 2012 |
Sample Use Guides
Iroxanadine (BRX-235) may improve survival of vascular endothelial cells (ECs) following ischemia/reperfusion stress. ECs cultured from human umbilical veins were exposed to hypoxia/reoxygenation to mimic ischemia/reperfusion. Caspase activation and apoptosis were monitored in the reoxygenated cells. Addition of BRX-235 (0.1-1 microM) to culture medium prior to hypoxia or at start of reoxygenation significantly reduced the caspase-dependent apoptosis. The cytoprotection conferred by the pre-hypoxic drug administration was sensitive to quercetin and seems to be based on enhanced heat shock protein accumulation in stressed ECs.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:05:30 UTC 2023
by
admin
on
Sat Dec 16 09:05:30 UTC 2023
|
| Record UNII |
3NXX6SVU3A
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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276690-59-6
Created by
admin on Sat Dec 16 09:05:30 UTC 2023 , Edited by admin on Sat Dec 16 09:05:30 UTC 2023
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3NXX6SVU3A
Created by
admin on Sat Dec 16 09:05:30 UTC 2023 , Edited by admin on Sat Dec 16 09:05:30 UTC 2023
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PRIMARY |
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PARENT -> SALT/SOLVATE |
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