Obertamig

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 17:44:19 GMT 2025` Edited by `admin` on `Wed Apr 02 17:44:19 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	3NCP89Y74H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Immunoglobulin G1 [263-serine,277-alanine,278-alanine,308-serine,393-valine,409-leucine,435-leucine,437-tryptophan], anti-(human histocompatibility antigen HLA-G ?-chain) (human monoclonal MHGB732 single-chain variable fragment VL-(GGSEGKSSGSGSESKSTGGS)-

Preferred Name

English

Obertamig

Official Name

English

immunoglobulin half IG G1-lambda2/scFv-h-CH2-CH3, anti-[Homo sapiens CD3E (CD3 epsilon)] and anti-[Homo sapiens HLA-G (class I major histocompatibility (MH1) antigen G, human leucocyte antigen G) C-like domain], Homo sapiens monoclonal antibody, bispecif

Common Name

English

obertamig [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C199013

Created by admin on Wed Apr 02 17:44:19 GMT 2025 , Edited by admin on Wed Apr 02 17:44:19 GMT 2025

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SMS_ID

300000050103

Created by admin on Wed Apr 02 17:44:19 GMT 2025 , Edited by admin on Wed Apr 02 17:44:19 GMT 2025

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FDA UNII

3NCP89Y74H

Created by admin on Wed Apr 02 17:44:19 GMT 2025 , Edited by admin on Wed Apr 02 17:44:19 GMT 2025

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INN

12551

Created by admin on Wed Apr 02 17:44:19 GMT 2025 , Edited by admin on Wed Apr 02 17:44:19 GMT 2025

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CAS

2750126-32-8

Created by admin on Wed Apr 02 17:44:19 GMT 2025 , Edited by admin on Wed Apr 02 17:44:19 GMT 2025

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From	To
2_370	2_428
2_264	2_324
2_223	3_215
2_147	2_203
2_22	2_99
1_410	1_468
1_304	1_364
1_272	2_232
1_269	2_229
1_155	1_232
1_23	1_94

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_340
N	2_300

Related Record Type Details


					ZLW14X2D30

CD3

TARGET -> ACTIVATOR

Amount:

Related Record Type Details


					3NCP89Y74H

Obertamig

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[2_1] [3_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_490] [2_450]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL