SULFAMETROLE SODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H9N4O3S2.Na
Molecular Weight	308.313
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].COC1=NSN=C1[N-]S(=O)(=O)C2=CC=C(N)C=C2

InChI

InChIKey=JCHKHKZWVLSCQY-UHFFFAOYSA-N

InChI=1S/C9H9N4O3S2.Na/c1-16-9-8(11-17-12-9)13-18(14,15)7-4-2-6(10)3-5-7;/h2-5H,10H2,1H3;/q-1;+1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C9H10N4O3S2
Molecular Weight	286.331
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21741802 | https://www.ncbi.nlm.nih.gov/pubmed/24257317 | https://www.ncbi.nlm.nih.gov/pubmed/6343878

Sulfametrole is a sulfonamide antibiotic used typically in combination with trimethoprim. Sulfametrole combined with trimethoprim could provide a choice for difficult-to-treat infections, particularly when administered intravenously. Sulfametrole/trimethoprim is an alternative sulphonamide/trimethoprim combination available in several EU countries, including Austria and the Netherlands. Sulphonamide/trimethoprim combination is the most active antibacterial but sulfametrole and sulfametrole/trimethoprim did not overcome resistance to sulfamethoxazole and sulfamethoxazole/trimethoprim in Enterobacteriaceae.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dihydropteroate synthase 3 Target ID: CHEMBL4032 Sources: http://www.tf.ni.ac.rs/casopis-arhiva/sveska6vol1/c8.pdf	Inhibitor 8297

PubMed

Title	Date	PubMed
Order-disorder enantiotropy, monotropy, and isostructurality in a tetroxoprim-sulfametrole 1:1 molecular complex: Crystallographic and thermal studies.	2003 Nov	14603502
Synthesis, spectroscopic, thermal and antimicrobial studies of some novel metal complexes of Schiff base derived from [N1-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfanilamide] and 2-thiophene carboxaldehyde.	2007 Apr	16920390
Metal complexes of Schiff base derived from sulphametrole and o-vanilin. Synthesis, spectral, thermal characterization and biological activity.	2007 Apr	16891151

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:53:48 GMT 2023` Edited by `admin` on `Fri Dec 15 15:53:48 GMT 2023`
Record UNII	3N7Z5H82LD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SULFAMETROLE SODIUM

Common Name

English

BENZENESULFONAMIDE, 4-AMINO-N-(4-METHOXY-1,2,5-THIADIAZOL-3-YL)-, SODIUM SALT (1:1)

Common Name

English

Sulfametrole sodium [WHO-DD]

Common Name

English

Code System Code Type Description

PUBCHEM

71587257