U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 23:02:53 GMT 2025
Edited
by admin
on Tue Apr 01 23:02:53 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG4
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
3L7R886Y06
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SABATOLIMAB
USAN   INN  
Official Name English
sabatolimab [INN]
Preferred Name English
Sabatolimab [WHO-DD]
Common Name English
MBG453
Code English
NVP-MBG453
Code English
ANTI-TIM-3 MONOCLONAL ANTIBODY MBG453
Common Name English
IMMUNOGLOBULIN G4 (226-PROLINE,DE-C-TERMINAL-LYSINE), ANTI-(HUMAN HEPATITIS VIRUS A CELLULAR RECEPTOR 2) (HUMAN-MUS MUSCULUS MONOCLONAL CLONE NVS260714 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL CLONE NVS260714 .KAPPA.-CHAIN, DIMER
Common Name English
ANTI-TIM3 CHECKPOINT INHIBITOR MBG453
Common Name English
SABATOLIMAB [JAN]
Common Name English
SABATOLIMAB [USAN]
Common Name English
MBG-453
Code English
IMMUNOGLOBULIN G4-KAPPA, ANTI-(HOMO SAPIENS HAVCR2 (HEPATITIS A VIRUS CELLULAR RECEPTOR 2, T-CELL IMMUNOGLOBULIN MUCIN FAMILY MEMBER 3, TIM-3, TIM3, TIMD3, CD366)), HUMANIZED MONOCLONAL ANTIBODY
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C129820
Created by admin on Tue Apr 01 23:02:53 GMT 2025 , Edited by admin on Tue Apr 01 23:02:53 GMT 2025
NCI_THESAURUS C20401
Created by admin on Tue Apr 01 23:02:53 GMT 2025 , Edited by admin on Tue Apr 01 23:02:53 GMT 2025
NCI_THESAURUS C129822
Created by admin on Tue Apr 01 23:02:53 GMT 2025 , Edited by admin on Tue Apr 01 23:02:53 GMT 2025
Code System Code Type Description
FDA UNII
3L7R886Y06
Created by admin on Tue Apr 01 23:02:53 GMT 2025 , Edited by admin on Tue Apr 01 23:02:53 GMT 2025
PRIMARY
CAS
2128742-61-8
Created by admin on Tue Apr 01 23:02:53 GMT 2025 , Edited by admin on Tue Apr 01 23:02:53 GMT 2025
NO STRUCTURE GIVEN
SMS_ID
300000023293
Created by admin on Tue Apr 01 23:02:53 GMT 2025 , Edited by admin on Tue Apr 01 23:02:53 GMT 2025
PRIMARY
NCI_THESAURUS
C124850
Created by admin on Tue Apr 01 23:02:53 GMT 2025 , Edited by admin on Tue Apr 01 23:02:53 GMT 2025
PRIMARY
USAN
JK-100
Created by admin on Tue Apr 01 23:02:53 GMT 2025 , Edited by admin on Tue Apr 01 23:02:53 GMT 2025
PRIMARY
INN
11256
Created by admin on Tue Apr 01 23:02:53 GMT 2025 , Edited by admin on Tue Apr 01 23:02:53 GMT 2025
PRIMARY
NCI_THESAURUS
C125187
Created by admin on Tue Apr 01 23:02:53 GMT 2025 , Edited by admin on Tue Apr 01 23:02:53 GMT 2025
ALTERNATIVE
CAS
2252262-24-9
Created by admin on Tue Apr 01 23:02:53 GMT 2025 , Edited by admin on Tue Apr 01 23:02:53 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_132 4_218
2_145 2_201
2_259 2_319
1_132 3_218
2_365 2_423
3_23 3_92
3_138 3_198
4_23 4_92
4_138 4_198
1_145 1_201
1_224 2_224
1_227 2_227
1_259 1_319
1_365 1_423
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_295
N 2_295
Related Record Type Details
HEPATITIS A VIRUS CELLULAR RECEPTOR 2
TARGET -> INHIBITOR
Related Record Type Details
SABATOLIMAB
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS Amount: PIDOLIC ACID SZB83O1W42
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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