ROSTEROLONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H38O2
Molecular Weight	346.5466
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4CC(=O)C[C@H](C)[C@]4(C)[C@H]3CC[C@]12C

InChI

InChIKey=IMFNBOMNWHWKQD-MXENSADDSA-N

InChI=1S/C23H38O2/c1-5-10-23(25)12-9-19-18-7-6-16-14-17(24)13-15(2)22(16,4)20(18)8-11-21(19,23)3/h15-16,18-20,25H,5-14H2,1-4H3/t15-,16-,18-,19-,20-,21-,22-,23-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C23H38O2
Molecular Weight	346.5466
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: Luderschmidt, C., Eiermann, W., Jawny, J. et al. Naunyn-Schmiedeberg's Arch. Pharmacol. (1984) 328: 214., retrieved from: https://doi.org/10.1007/BF00512076

Rosterolone (also known as a17α-propylmesterolone) is a synthetic 5alpha-reduced steroid that was studied for acne treatment on animal models. It was shown that the topical administration was more effective than systemic treatment. Rosterolone exerted a potent topical sebosuppressive effect in the animal model. This compound has never been marketed.

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:30:48 GMT 2025` Edited by `admin` on `Mon Mar 31 18:30:48 GMT 2025`
Record UNII	3L5C5C8ZNG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ROSTEROLONE

Official Name

English

rosterolone [INN]

Preferred Name

English

Classification Tree Code System Code

NCI_THESAURUS

C243