Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H12Cl2N2 |
| Molecular Weight | 267.154 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=CC=C(CC2=CC=C(N)C(Cl)=C2)C=C1Cl
InChI
InChIKey=IBOFVQJTBBUKMU-UHFFFAOYSA-N
InChI=1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2
| Molecular Formula | C13H12Cl2N2 |
| Molecular Weight | 267.154 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens. | 2015-08-17 |
|
| Cancer incidence and exposure to 4,4'-methylene-bis-ortho-chloroaniline (MbOCA). | 2009-09 |
|
| A survey of occupational exposure to 4,4'-methylene-bis (2-chloroaniline) (MbOCA) in the UK. | 2009-07 |
|
| Simultaneous analysis of urinary 4,4'-methylenebis(2-chloroaniline) and N-acetyl 4,4'-methylenebis(2-chloroaniline) using solid-phase extraction and liquid chromatography/tandem mass spectrometry. | 2007 |
|
| Identification and characterization of functional rat arylamine N-acetyltransferase 3: comparisons with rat arylamine N-acetyltransferases 1 and 2. | 2006-10 |
|
| Differential induction of micronuclei in peripheral lymphocytes and exfoliated urothelial cells of workers exposed to 4,4'-methylenebis-(2-chloroaniline) (MOCA) and bitumen fumes. | 2005-12-13 |
|
| Bladder cancer screening and monitoring of 4,4'-methylenebis(2-chloroaniline) exposure among workers in Taiwan. | 2005-08 |
|
| Occupational bladder cancer in a 4,4 -methylenebis(2-chloroaniline) (MBOCA)-exposed worker. | 2005-06 |
|
| Embryonic turkey liver: activities of biotransformation enzymes and activation of DNA-reactive carcinogens. | 2004-10 |
|
| Assessment of the performance of the Ames II assay: a collaborative study with 19 coded compounds. | 2004-03-14 |
|
| 4,4'-Methylenebis(2-chloroaniline). | 2004 |
|
| Lack of DNA binding in the rat nasal mucosa and other tissues of the nasal toxicants roflumilast, a phosphodiesterase 4 inhibitor, and a metabolite, 4-amino-3,5-dichloropyridine, in contrast to the nasal carcinogen 2,6-dimethylaniline. | 2002-02 |
|
| 4,4'-Methylenebis(2-chloroaniline). | 2002 |
|
| Carcinogen substrate specificity of human COX-1 and COX-2. | 2001-01 |
|
| Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation. | 1997-08-01 |
|
| Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline). | 1992-02 |
|
| 4,4'-Methylenebis(2-chloroaniline) (MOCA): the effect of multiple oral administration, route, and phenobarbital induction on macromolecular adduct formation in the rat. | 1991-01 |
|
| Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases. | 1989-01-01 |
|
| Bladder tumors in two young males occupationally exposed to MBOCA. | 1988 |
|
| Determination of the tumorigenic potential of methylene-bis-orthochloroaniline. | 1979-05-01 |
|
| Urinary bladder tumors in dogs from 4,4'-methylene-bis (2-chloroaniline) (MOCA). | 1978-09-01 |
|
| Experimental neoplasia in rats from oral administration of 3,3'-dichlorobenzidine, 4,4'-methylene-bis-bis(2-chloroaniline), and 4,4'-methylene-bis(2-methylaniline). | 1975-01 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:26:47 GMT 2025
by
admin
on
Mon Mar 31 19:26:47 GMT 2025
|
| Record UNII |
3L2W5VTT2A
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
202-918-9
Created by
admin on Mon Mar 31 19:26:47 GMT 2025 , Edited by admin on Mon Mar 31 19:26:47 GMT 2025
|
PRIMARY | |||
|
3L2W5VTT2A
Created by
admin on Mon Mar 31 19:26:47 GMT 2025 , Edited by admin on Mon Mar 31 19:26:47 GMT 2025
|
PRIMARY | |||
|
m7401
Created by
admin on Mon Mar 31 19:26:47 GMT 2025 , Edited by admin on Mon Mar 31 19:26:47 GMT 2025
|
PRIMARY | Merck Index | ||
|
4,4'-Methylenebis(2-chloroaniline)
Created by
admin on Mon Mar 31 19:26:47 GMT 2025 , Edited by admin on Mon Mar 31 19:26:47 GMT 2025
|
PRIMARY | |||
|
101-14-4
Created by
admin on Mon Mar 31 19:26:47 GMT 2025 , Edited by admin on Mon Mar 31 19:26:47 GMT 2025
|
PRIMARY | |||
|
C44319
Created by
admin on Mon Mar 31 19:26:47 GMT 2025 , Edited by admin on Mon Mar 31 19:26:47 GMT 2025
|
PRIMARY | |||
|
7543
Created by
admin on Mon Mar 31 19:26:47 GMT 2025 , Edited by admin on Mon Mar 31 19:26:47 GMT 2025
|
PRIMARY | |||
|
DTXSID5020865
Created by
admin on Mon Mar 31 19:26:47 GMT 2025 , Edited by admin on Mon Mar 31 19:26:47 GMT 2025
|
PRIMARY | |||
|
300000053717
Created by
admin on Mon Mar 31 19:26:47 GMT 2025 , Edited by admin on Mon Mar 31 19:26:47 GMT 2025
|
PRIMARY | |||
|
2629
Created by
admin on Mon Mar 31 19:26:47 GMT 2025 , Edited by admin on Mon Mar 31 19:26:47 GMT 2025
|
PRIMARY | |||
|
52954
Created by
admin on Mon Mar 31 19:26:47 GMT 2025 , Edited by admin on Mon Mar 31 19:26:47 GMT 2025
|
PRIMARY |