Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H8N2O2 |
| Molecular Weight | 116.1185 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=NN1CCOCC1
InChI
InChIKey=ZKXDGKXYMTYWTB-UHFFFAOYSA-N
InChI=1S/C4H8N2O2/c7-5-6-1-3-8-4-2-6/h1-4H2
| Molecular Formula | C4H8N2O2 |
| Molecular Weight | 116.1185 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver. | 1990 Apr |
|
| Toxicological studies on a benzofurane derivative. I. A comparative study with phenobarbital on rat liver. | 1990 Dec |
|
| Overexpression of P-glycoprotein in rat hepatocellular carcinomas induced with N-nitrosomorpholine. | 1990 Jan |
|
| Site-specific hypomethylation of c-myc protooncogene in liver nodules and inhibition of DNA methylation by N-nitrosomorpholine. | 1991 Jul 5 |
|
| Inhibition by retinoic acid of hepatocarcinogenesis induced by N-nitrosomorpholine and of expression of myc oncogene protein in Sprague-Dawley rats. | 1991 Sep 30 |
|
| N-Nitrosomorpholine. | 2004 |
|
| Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine. | 2005 |
|
| The carcinogenic significance of reactive intermediates derived from 3-acetoxy- and 5-acetoxy-2-hydroxy-N-nitrosomorpholine. | 2005 Dec |
|
| Effects of dietary intake of a fungal beta-D-glucan derivative on the level of DNA damage induced in primary rat hepatocytes by various carcinogens. | 2006 |
|
| Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition. | 2006 Apr |
|
| Application of a color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment. | 2006 Aug |
|
| Comparison of software tools to improve the detection of carcinogen induced changes in the rat liver proteome by analyzing SELDI-TOF-MS spectra. | 2006 Feb |
|
| Synthesis and aqueous chemistry of alpha-acetoxy-N-nitrosomorpholine: reactive intermediates and products. | 2006 Jan 6 |
|
| Comparative evaluation of DNA damage by genotoxicants in primary rat cells applying the comet assay. | 2006 Jun 20 |
|
| Proteomics: recent applications and new technologies. | 2006 May |
|
| Occurrence and fate of nitrosamines and nitrosamine precursors in wastewater-impacted surface waters using boron as a conservative tracer. | 2006 May 15 |
|
| Divide and conquer: rat liver tissue proteomics based on the analysis of purified constituents. | 2006 Oct |
|
| Hepatic progenitor cells, stem cells, and AFP expression in models of liver injury. | 2006 Oct |
|
| Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication. | 2007 Aug |
|
| Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation. | 2007 Dec |
|
| Pravastatin reduces lung metastasis of rat hepatocellular carcinoma via a coordinated decrease of MMP expression and activity. | 2007 Jan |
|
| N-nitrosamine generation from ingested nitrate via nitric oxide in subjects with and without gastroesophageal reflux. | 2007 Jul |
|
| Occupational exposure to NDMA and NMor in the European rubber industry. | 2007 Mar |
|
| The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract. | 2007 Mar |
|
| Prevalidation of potential protein biomarkers in toxicology using iTRAQ reagent technology. | 2007 May |
|
| Comparison of mode of action of four hepatocarcinogens: a model-based approach. | 2007 Oct |
|
| Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype. | 2008 |
|
| Reduction of genotoxic effects of N-nitrosomorpholine in human hepatoma cells and hamster lung cells by carboxymethyl chitin-glucan. | 2008 |
|
| Analysis of nitrosamines in wastewater: exploring the trace level quantification capabilities of a hybrid linear ion trap/orbitrap mass spectrometer. | 2008 Feb 1 |
|
| Formation of N-nitrosamines from eleven disinfection treatments of seven different surface waters. | 2008 Jul 1 |
|
| Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants. | 2008 Jun 16 |
|
| Gene set enrichment analysis for non-monotone association and multiple experimental categories. | 2008 Nov 14 |
|
| Proteomics reveals acute pro-inflammatory and protective responses in rat Kupffer cells and hepatocytes after chemical initiation of liver cancer and after LPS and IL-6. | 2009 Aug |
|
| Toxicogenomic analysis of N-nitrosomorpholine induced changes in rat liver: comparison of genomic and proteomic responses and anchoring to histopathological parameters. | 2009 Dec 1 |
|
| Highly sensitive method for determination of N-nitrosamines using high-performance liquid chromatography with online UV irradiation and luminol chemiluminescence detection. | 2009 Jan 2 |
|
| Discernment of possible mechanisms of hepatotoxicity via biological processes over-represented by co-expressed genes. | 2009 Jun 18 |
|
| [Prevention of hepatic tumor growth and metastasis in rats with rapamycin]. | 2009 Mar |
|
| Expression and correlation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor and microvessel density in experimental rat hepatocarcinogenesis. | 2009 Mar-Apr |
|
| Occurrence and removal of N-nitrosamines in wastewater treatment plants. | 2009 Sep |
|
| Application of a two-phenotype color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment. | 2010 Apr |
|
| Fully automated determination of N-nitrosamines in environmental waters by headspace solid-phase microextraction followed by GC-MS-MS. | 2010 Dec |
|
| Evaluation of the protective effect of ascorbic acid on nitrite- and nitrosamine-induced cytotoxicity and genotoxicity in human hepatoma line. | 2010 Feb |
|
| Products of the direct reaction of the diazonium ion of a metabolite of the carcinogen N-nitrosomorpholine with purines of nucleosides and DNA. | 2010 Jul 19 |
|
| Screening of N-nitrosamines in tap and swimming pool waters using fast gas chromatography. | 2010 Mar |
|
| Fate of nine recycled water trace organic contaminants and metal(loid)s during managed aquifer recharge into a anaerobic aquifer: Column studies. | 2010 Mar |
|
| Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. | 2010 Mar 15 |
|
| Effect of allyl isothiocyanate (AITC) in both nitrite- and nitrosamine-induced cell death, production of reactive oxygen species, and DNA damage by the single-cell gel electrophoresis (SCGE): does it have any protective effect on HepG2 cells? | 2010 May-Jun |
|
| UVA activation of N-dialkylnitrosamines releasing nitric oxide, producing strand breaks as well as oxidative damages in DNA, and inducing mutations in the Ames test. | 2010 Sep 10 |
|
| New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats. | 2011 |
|
| Upregulation of the insulin receptor and type I insulin-like growth factor receptor are early events in hepatocarcinogenesis. | 2011 Apr |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:29:43 GMT 2023
by
admin
on
Fri Dec 15 19:29:43 GMT 2023
|
| Record UNII |
3L25FO7FN7
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Code | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
IARC | <i>N</i>-Nitrosomorpholine | ||
|
NCI_THESAURUS |
C45402
Created by
admin on Fri Dec 15 19:29:43 GMT 2023 , Edited by admin on Fri Dec 15 19:29:43 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
C44420
Created by
admin on Fri Dec 15 19:29:43 GMT 2023 , Edited by admin on Fri Dec 15 19:29:43 GMT 2023
|
PRIMARY | |||
|
6046
Created by
admin on Fri Dec 15 19:29:43 GMT 2023 , Edited by admin on Fri Dec 15 19:29:43 GMT 2023
|
PRIMARY | |||
|
DTXSID4021056
Created by
admin on Fri Dec 15 19:29:43 GMT 2023 , Edited by admin on Fri Dec 15 19:29:43 GMT 2023
|
PRIMARY | |||
|
3L25FO7FN7
Created by
admin on Fri Dec 15 19:29:43 GMT 2023 , Edited by admin on Fri Dec 15 19:29:43 GMT 2023
|
PRIMARY | |||
|
m7997
Created by
admin on Fri Dec 15 19:29:43 GMT 2023 , Edited by admin on Fri Dec 15 19:29:43 GMT 2023
|
PRIMARY | Merck Index | ||
|
59-89-2
Created by
admin on Fri Dec 15 19:29:43 GMT 2023 , Edited by admin on Fri Dec 15 19:29:43 GMT 2023
|
PRIMARY | |||
|
4308
Created by
admin on Fri Dec 15 19:29:43 GMT 2023 , Edited by admin on Fri Dec 15 19:29:43 GMT 2023
|
PRIMARY | |||
|
76326
Created by
admin on Fri Dec 15 19:29:43 GMT 2023 , Edited by admin on Fri Dec 15 19:29:43 GMT 2023
|
PRIMARY | |||
|
139
Created by
admin on Fri Dec 15 19:29:43 GMT 2023 , Edited by admin on Fri Dec 15 19:29:43 GMT 2023
|
PRIMARY | |||
|
C002741
Created by
admin on Fri Dec 15 19:29:43 GMT 2023 , Edited by admin on Fri Dec 15 19:29:43 GMT 2023
|
PRIMARY |