ACETAMIDE, N-((2-(METHOXY)PHENYL)METHYL)-N-(6-PHENOXY-3-PYRIDINYL)-

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H20N2O3
Molecular Weight	348.3951
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ACETAMIDE, N-((2-(METHOXY)PHENYL)METHYL)-N-(6-PHENOXY-3-PYRIDINYL)-

Structure Search

SMILES

COC1=C(CN(C(C)=O)C2=CC=C(OC3=CC=CC=C3)N=C2)C=CC=C1

InChI

InChIKey=SLJDUPUOYWPBAB-UHFFFAOYSA-N

InChI=1S/C21H20N2O3/c1-16(24)23(15-17-8-6-7-11-20(17)25-2)18-12-13-21(22-14-18)26-19-9-4-3-5-10-19/h3-14H,15H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C21H20N2O3
Molecular Weight	348.3951
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30463776 | https://www.ncbi.nlm.nih.gov/pubmed/18024084 | https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/pbr28-pet-in-inflammatory-joint-disease-astrid/

PBR28 or PBR-28, a chemical substance that binds to translocator protein TSPO, also known as Peripheral-type benzodiazepine receptor (PBR). TSPO located within the cells such as macrophages reaches high levels of expression in inflammatory conditions and thus can be a biomarker of neuroinflammation. When radioactivity in the form of carbon-11 is tagged to PBR 28 and is administered, its uptake in the inflammatory body regions can be measured using positron emission tomography (PET). PBR28 now is involved in a clinical trial to evaluate the specificity of its binding in the joints of patients with inflammatory joint disease, like rheumatoid and psoriatic arthritis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Translocator protein 13 Target ID: P30536 Gene ID: 706.0 Gene Symbol: TSPO Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/18024084	Binding Agent 1064		0.59 nM [Ki]

PubMed

Title	Date	PubMed
Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors.	2008 Feb 1	18024084
Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28.	2015	25685708
Tracking Macrophage Infiltration in a Mouse Model of Pancreatic Cancer with the Positron Emission Tomography Tracer [11C]PBR28.	2018 Dec	30463776

Sample Use Guides

In Vivo Use Guide

Whole-body peripheral benzodiazepine receptor (PBR) images were acquired after intravenous bolus administration of (11)C-PBR28 in 7 healthy humans (651 +/- 111 MBq)

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:25:46 GMT 2023` Edited by `admin` on `Sat Dec 16 08:25:46 GMT 2023`
Record UNII	3KRN834K22
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACETAMIDE, N-((2-(METHOXY)PHENYL)METHYL)-N-(6-PHENOXY-3-PYRIDINYL)-

Systematic Name

English

Code System Code Type Description

FDA UNII

3KRN834K22

Created by admin on Sat Dec 16 08:25:46 GMT 2023 , Edited by admin on Sat Dec 16 08:25:46 GMT 2023

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PUBCHEM

76972681

Created by admin on Sat Dec 16 08:25:46 GMT 2023 , Edited by admin on Sat Dec 16 08:25:46 GMT 2023

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Related Record Type Details


					82MI0GT75Z

PBR-28 C-11

LABELED -> NON-LABELED

Amount: