Details
Stereochemistry | ACHIRAL |
Molecular Formula | C18H40O4P2 |
Molecular Weight | 382.4553 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOCCP(CCOCC)CCP(CCOCC)CCOCC
InChI
InChIKey=QCWJONLQSHEGEJ-UHFFFAOYSA-N
InChI=1S/C18H40O4P2/c1-5-19-9-13-23(14-10-20-6-2)17-18-24(15-11-21-7-3)16-12-22-8-4/h5-18H2,1-4H3
Molecular Formula | C18H40O4P2 |
Molecular Weight | 382.4553 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Tetrofosmin is a phosphor-organic compound, belonging to the group of diphosphines. Tetrofosmin is used as a component of a Technetium (99mTc) tetrofosmin complex. Due to the relatively short half-life of Tc99m (6 hours), just before the administration, the solution of tetrofosmin should be reconstituted with Tc99m pertechnetate to form a complex of Tc99m Tetrofosmin. When administered intravenously, Tc99m Tetrofosmin shows rapid myocardial uptake and its distribution follows a linear relationship with coronary blood flow. It is taken up by the mitochondria of myocardial cells by passive diffusion and appears to accumulate in viable myocardial tissue. Tc99m Tetrofosmin is used as a diagnostic agent used to assess areas of reversible myocardial ischemia in the presence or absence of infracted myocardium and is also used to assess ventricular function.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Diagnostic | MYOVIEW Approved UseMYOVIEW is indicated for scintigraphic imaging of the myocardium following separate administrations under exercise and/or resting conditions. It is useful in the delineation of regions of reversible myocardial ischemia in the presence or absence of infarcted myocardium. MYOVIEW is also indicated for scintigraphic imaging of the myocardium to identify changes in perfusion induced by pharmacologic stress in patients with known or suspected coronary artery disease. MYOVIEW is also indicated for the assessment of left ventricular function (left ventricular ejection fraction and wall motion) in patients being evaluated for heart disease. Launch Date1996 |
PubMed
Title | Date | PubMed |
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Recurrent hyperparathyroidism after total parathyroidectomy due to multiple ectopic parathyroid glands in a patient with long-term haemodialysis. | 2001 |
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[Welcome the multicenter studies]. | 2001 Apr |
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[Utility of SPECT with 99m Tc-tetrofosmin and stimulus with dipyridamole in patients with permanent ventricular pacemakers]. | 2001 Apr |
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Assessment of ampulla (Takotsubo) cardiomyopathy with coronary angiography, two-dimensional echocardiography and 99mTc-tetrofosmin myocardial single photon emission computed tomography. | 2001 Aug |
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Dynamic changes in cardiac fatty acid metabolism in the stunned human myocardium. | 2001 Aug |
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Study of tea polyphenol as a reversal agent for carcinoma cell lines' multidrug resistance (study of TP as a MDR reversal agent). | 2001 Aug |
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To predict chemotherapy response using technetium-99m tetrofosmin and compare with p-glycoprotein and multidrug resistance related protein-1 expression in patients with untreated small cell lung cancer. | 2001 Aug 28 |
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99mTc-Tetrofosmin pinhole-SPECT (P-SPECT) and radioguided sentinel node (SN) biopsy and in breast cancer axillary lymph node staging. | 2001 Dec |
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Duodenogastric reflux on (99m)Tc-tetrofosmin myocardial SPECT mimics left ventricle inferior wall reverse redistribution and falsely decreases ejection fraction: a case report. | 2001 Dec |
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Evaluation of left ventricular function using electrocardiographically gated myocardial SPECT with (123)I-labeled fatty acid analog. | 2001 Dec |
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Significance of reduced uptake of iodinated fatty acid analogue for the evaluation of patients with acute chest pain. | 2001 Dec |
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Technetium-99m tetrofosmin for parathyroid scintigraphy: a direct comparison with (99m)Tc-MIBI, (201)Tl, MRI and US. | 2001 Dec |
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Early detection of myocardial ischaemia in the emergency department by rest or exercise (99m)Tc tracer myocardial SPET in patients with chest pain and non-diagnostic ECG. | 2001 Dec |
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(99)mTc-tetrofosmin SPET in the detection of both primary breast cancer and axillary lymph node metastasis. | 2001 Dec |
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Comparison between rest technetium-99m-tetrofosmin and rest-redistribution thallium-201 SPECT in stable patients with healed myocardial infarction. | 2001 Dec |
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Assessment of adenosine, arbutamine and dobutamine as pharmacological stress agents during (99m)Tc-tetrofosmin SPECT imaging: a randomized study. | 2001 Dec |
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Comparison of image reconstruction algorithms in myocardial perfusion scintigraphy. | 2001 Feb |
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Comparison of 99mTc-tetrofosmin uptakes on planar images with those in excised rats organs. | 2001 Feb |
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Technetium-99m-tetrofosmin scintigraphy in the prediction of chemotherapy response of untreated malignant lymphomas and comparison with other prognostic factors. | 2001 Jan-Feb |
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99Tc(m)-tetrofosmin scintimammography for detecting breast cancer: a comparative study with 99Tc(m)-MIBI. | 2001 Jul |
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99mTc-tetrofosmin for functional imaging of P-glycoprotein modulation in vivo. | 2001 Jul |
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The volume effect of the stomach on intestinal activity on same-day exercise--rest Tc-99m tetrofosmin myocardial imaging. | 2001 Jul |
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Comparing 18-fluoro-2-deoxyglucose positron emission tomography with a combination of technetium 99m tetrofosmin single photon emission computed tomography and computed tomography to detect recurrent or persistent nasopharyngeal carcinomas after radiotherapy. | 2001 Jul 15 |
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Incremental prognostic value of technetium-99m-tetrofosmin exercise myocardial perfusion imaging for predicting outcomes in patients with suspected or known coronary artery disease. | 2001 Jul 15 |
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[Stress-rest myocardial tomoscintigraphy with 99mTc-tetrofosmin in the diagnosis of ischemic disease]. | 2001 Jul-Aug |
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Detection of esophagitis by technetium 99m tetrofosmin chest SPECT. | 2001 Jun |
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Post-stress end-systolic left ventricular dilation: a marker of endocardial post-ischemic stunning. | 2001 Jun |
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A rapid and stable ITLC procedure for the determination of the radiochemical purity of 99Tcm-tetrofosmin. | 2001 Jun |
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Perfusion and functional abnormalities outside the septal region in patients with left bundle branch block assessed with gated SPECT. | 2001 Mar |
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Technetium-99m tetrofosmin scintigraphy for detecting malignant lymphoma. | 2001 Mar-Apr |
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Serial assessment of left ventricular function during dobutamine stress by means of electrocardiography-gated myocardial SPECT: combination with dual-isotope myocardial perfusion SPECT for detection of ischemic heart disease. | 2001 Mar-Apr |
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Prognostic assessment of uncomplicated first myocardial infarction by exercise echocardiography and Tc-99m tetrofosmin gated SPECT. | 2001 Mar-Apr |
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[The use of imaging modalities in patient with thyroid nodule: ultrasonography and radionuclide scintigraphy with new tracers]. | 2001 May |
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Age- and gender-specific differences in left ventricular cardiac function and volumes determined by gated SPET. | 2001 May |
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Detection of malignant thymoma in primary tumor and metastatic lesions using 99mTc-tetrofosmin scintigraphy. | 2001 May-Jun |
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[Examination concerning dissociation of left ventricular volume calculation value based on difference of analytical algorithm and perfusion tracer in gated myocardial SPECT]. | 2001 Nov |
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Giant mediastinal parathyroid adenoma in a woman with hypercalcemia. | 2001 Nov |
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Early identification of impaired myocardial reperfusion with serial assessment of ST segments after percutaneous transluminal coronary angioplasty during acute myocardial infarction. | 2001 Nov 1 |
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[An approach for comparative quantification of myocardial blood flow (O-15-H2O-PET), perfusion (Tc-99m-tetrofosmin-SPECT) and metabolism (F-18-FDG-PET)]. | 2001 Oct |
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[Prognostic value of myocardial perfusion SPECT in multivessel coronary disease patients with left ventricular dysfunction, comparing revascularized and non-revascularized patients]. | 2001 Oct |
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Rapid quality control for testing the radiochemical purity of 99Tc(m)-tetrofosmin. | 2001 Oct |
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Exercise-induced myocardial perfusion abnormalities in sickle beta-thalassemia: Tc-99m tetrofosmin gated SPECT imaging study. | 2001 Oct 1 |
|
[Usefulness of combination post-stress dysfunction and perfusion imaging in technetium-99m-tetrofosmin myocardial scintigraphy]. | 2001 Sep |
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Time course evaluation of myocardial perfusion after reperfusion therapy by 99mTc-tetrofosmin SPECT in patients with acute myocardial infarction. | 2001 Sep |
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Quantification of limited augmentation of myocardial (99m)Tc-tetrofosmin uptake at exercise in stable coronary artery disease. | 2001 Sep |
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Predicting chemotherapy response and comparing with P-glycoprotein expression using technetium-99m tetrofosmin scan in untreated malignant lymphomas. | 2001 Sep 20 |
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Comparison of technetium-99m tetrofosmin and gallium-67 citrate scintigraphy for detecting malignant lymphoma. | 2001 Sep-Oct |
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[Study of pulmonary lesions with (99m)Tc-Tetrafosmin and chest spect. Determination of uptake related factors, diagnostic value and prognosis]. | 2002 Apr |
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Feasibility of myocardial dual-isotope perfusion imaging combined with gated single photon emission tomography for assessing coronary artery disease. | 2002 Jan |
|
Scintigraphic prediction of response to chemotherapy in patients with breast cancer: Technetium 99m-tetrofosmin and thallium-201 dual single photon emission computed tomography. | 2002 Jan |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:30:13 GMT 2023
by
admin
on
Fri Dec 15 15:30:13 GMT 2023
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Record UNII |
3J0KPB596Q
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C1937
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EU-Orphan Drug |
EU/3/16/1764
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DB11180
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m10665
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3J0KPB596Q
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4274
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