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Details

Stereochemistry ACHIRAL
Molecular Formula C4H10N2O
Molecular Weight 102.135
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of N-Nitrosodiethylamine

SMILES

CCN(CC)N=O

InChI

InChIKey=WBNQDOYYEUMPFS-UHFFFAOYSA-N
InChI=1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C4H10N2O
Molecular Weight 102.135
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation.
1999 Aug
Mutagenicity of nitrosamines in methyltransferase-deficient strains of Salmonella typhimurium coexpressing human cytochrome P450 2E1 and reductase.
2000 Nov 6
Ovarian tumors in rats induced by chronic 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment.
2000 Oct 1
Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase.
2001
Vitamin A and all-trans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats.
2001
Nitric oxide synthase inhibitors reduced lipid peroxidation in N-nitrosodiethylamine-treated rats.
2001
Nuclear Ras: unexpected subcellular distribution of oncogenic forms.
2001
Mutagen sensitivity of nasopharyngeal cancer patients.
2001 Apr 5
Hepatocellular expression of a dominant-negative mutant TGF-beta type II receptor accelerates chemically induced hepatocarcinogenesis.
2001 Aug 16
Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats.
2001 Dec
Cytochrome b(5) coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium.
2001 Dec 12
Alterations of the transforming growth factor-beta signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats.
2001 Jan
Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12.
2001 Jan
Induction of hepatic 8-oxo-deoxyguanosine adducts by 2,3,7,8-tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats is female-specific and estrogen-dependent.
2001 Jul
Preventive effect of FK143, a 5alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats.
2001 Jul
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
2001 Jun
Involvement of gap junctions in tumor suppression: analysis of genetically-manipulated mice.
2001 Jun 2
Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies.
2001 Jun 2
Liposome encapsulated tumor-associated antigens elicited humoral and cellular immune responses in mice bearing tumor.
2001 Mar
Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carcinoma.
2001 Mar
Effect of selenium on N-nitrosodiethylamine-induced multistage hepatocarcinogenesis with reference to lipid peroxidation and enzymic antioxidants.
2001 Mar
Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade.
2001 Mar 1
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.
2001 Mar 20
Specific genomic alterations in rat renal cell carcinomas induced by N-ethyl-N-hydroxyethylnitrosamine.
2001 Mar-Apr
DNA damage induced by red food dyes orally administered to pregnant and male mice.
2001 May
Expression profiling and identification of novel genes in hepatocellular carcinomas.
2001 May 10
An in vivo method for using 5-bromo-2'-deoxyuridine (BrdU) as a marker of chemically-induced hepatocellular proliferation in the Japanese medaka (Oryzias latipes).
2001 May-Jun
The polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline lacks liver tumor initiating and promoting activity in rats exposed to human-relevant doses.
2001 Nov
Organotropic chemopreventive effects of n-3 unsaturated fatty acids in a rat multi-organ carcinogenesis model.
2001 Nov
Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors.
2001 Nov 22
[Genetic control of hepatocarcinogenesis in mice].
2001 Oct
Inheritance of resistance to promotion of preneoplastic liver lesions in Copenhagen rats.
2001 Oct
Effect of alpha-tocopherol on hepatocarcinogenesis in transforming growth factor-alpha (TGF-alpha) transgenic mice treated with diethylnitrosamine.
2001 Sep
Diethylnitrosamine causes pituitary damage, disturbs hormone levels, and reduces sexual dimorphism of certain liver functions in the rat.
2001 Sep
Matrix metalloproteinases-2 and 9 do not play a role in the growth of preneoplastic liver lesions in F344 rats.
2001 Sep
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.
2001 Sep 15
Strain variation in renal carcinogenesis by N-ethyl-N-hydroxyethylnitrosamine in F1 (Wistar-Fischer) rats.
2001 Sep 20
Summation of initiation activities in the liver after partial hepatectomy.
2002 Feb 8
Substance Class Chemical
Created
by admin
on Mon Mar 31 20:06:41 GMT 2025
Edited
by admin
on Mon Mar 31 20:06:41 GMT 2025
Record UNII
3IQ78TTX1A
Record Status Validated (UNII)
Record Version
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Name Type Language
N-Nitrosodiethylamine
HSDB   MI  
Systematic Name English
NSC-132
Preferred Name English
DENA
Common Name English
Diethylamine, N-nitroso-
Systematic Name English
N-Nitrosodiethylamine [HSDB]
Common Name English
DEN
Common Name English
N-Nitrosodiethylamine [IARC]
Common Name English
N-Nitrosodiethylamine [USP-RS]
Common Name English
NDEA
Common Name English
N-Nitrosodiethylamine [MI]
Common Name English
Ethanamine, N-ethyl-N-nitroso-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C45398
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
IARC <i>N</i>-Nitrosodiethylamine
Code System Code Type Description
ECHA (EC/EINECS)
200-226-1
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
CHEBI
34873
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
RS_ITEM_NUM
1466652
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
NCI_THESAURUS
C29827
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
CAS
55-18-5
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
SMS_ID
300000053432
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
PUBCHEM
5921
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
FDA UNII
3IQ78TTX1A
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
HSDB
4001
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
EPA CompTox
DTXSID2021028
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
MERCK INDEX
m7993
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY Merck Index
WIKIPEDIA
N-Nitrosodiethylamine
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
NSC
132
Created by admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
PRIMARY
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