Details
Stereochemistry | ACHIRAL |
Molecular Formula | C4H10N2O |
Molecular Weight | 102.135 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(CC)N=O
InChI
InChIKey=WBNQDOYYEUMPFS-UHFFFAOYSA-N
InChI=1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
Molecular Formula | C4H10N2O |
Molecular Weight | 102.135 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
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Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase. | 2001 |
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Effects of griseofulvin in medium-term liver carcinogenesis assay and peripheral blood micronucleus test in rat. | 2001 |
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Nitric oxide synthase inhibitors reduced lipid peroxidation in N-nitrosodiethylamine-treated rats. | 2001 |
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Nuclear Ras: unexpected subcellular distribution of oncogenic forms. | 2001 |
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1alpha, 25-Dihydroxyvitamin D3 suppresses the effect of streptozotocin-induced diabetes during chemical rat liver carcinogenesis. | 2001 |
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Genotoxic effects of N-nitrosodicyclohexylamine in isolated human lymphocytes. | 2001 Apr |
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Proteome analysis of rat hepatomas: carcinogen-dependent tumor-associated protein variants. | 2001 Aug |
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Reaction of fumonisin with glucose prevents promotion of hepatocarcinogenesis in female F344/N rats while maintaining normal hepatic sphinganine/sphingosine ratios. | 2001 Aug |
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Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats. | 2001 Aug |
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Low gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in rats with cirrhosis and arthritis. | 2001 Aug |
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Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles. | 2001 Aug 15 |
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Hepatocellular expression of a dominant-negative mutant TGF-beta type II receptor accelerates chemically induced hepatocarcinogenesis. | 2001 Aug 16 |
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Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats. | 2001 Dec |
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Anticarcinogenic effect of red ginseng on the development of liver cancer induced by diethylnitrosamine in rats. | 2001 Dec |
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Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats. | 2001 Dec |
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Cytochrome b(5) coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium. | 2001 Dec 12 |
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Detection of DNA adducts using a quantitative long PCR technique and the fluorogenic 5' nuclease assay (TaqMan). | 2001 Dec 12 |
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Induction of hepatic 8-oxo-deoxyguanosine adducts by 2,3,7,8-tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats is female-specific and estrogen-dependent. | 2001 Jul |
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Preventive effect of FK143, a 5alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats. | 2001 Jul |
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Greater expression of transforming growth factor alpha and proliferating cell nuclear antigen staining in mouse hepatoblastomas than hepatocellular carcinomas induced by a diethylnitrosamine-sodium phenobarbital regimen. | 2001 Jul-Aug |
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Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. | 2001 Jun |
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Involvement of gap junctions in tumor suppression: analysis of genetically-manipulated mice. | 2001 Jun 2 |
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Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies. | 2001 Jun 2 |
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Liposome encapsulated tumor-associated antigens elicited humoral and cellular immune responses in mice bearing tumor. | 2001 Mar |
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Bioassay of mannitol and caprolactam and assessment of response to diethylnitrosamine in heterozygous p53-deficient (+/-) and wild type (+/+) mice. | 2001 Mar |
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Specific genomic alterations in rat renal cell carcinomas induced by N-ethyl-N-hydroxyethylnitrosamine. | 2001 Mar-Apr |
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Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis by phentoin in male F344/NCr rats at a dose causing maximal induction of CYP2B. | 2001 Mar-Apr |
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Inhibition of chemical carcinogenesis by berberine in rats and mice. | 2001 May |
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Expression profiling and identification of novel genes in hepatocellular carcinomas. | 2001 May 10 |
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An in vivo method for using 5-bromo-2'-deoxyuridine (BrdU) as a marker of chemically-induced hepatocellular proliferation in the Japanese medaka (Oryzias latipes). | 2001 May-Jun |
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Genotoxicity of nitroso compounds and sodium dichromate in a model combining organ cultures of human nasal epithelia and the comet assay. | 2001 May-Jun |
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Organotropic chemopreventive effects of n-3 unsaturated fatty acids in a rat multi-organ carcinogenesis model. | 2001 Nov |
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Rat oesophageal cytochrome P450 (CYP) monooxygenase system: comparison to the liver and relevance in N-nitrosodiethylamine carcinogenesis. | 2001 Nov |
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The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility. | 2001 Nov |
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The importance of distinct metabolites of N-nitrosodiethylamine for its in vivo mutagenic specificity. | 2001 Nov 1 |
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Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase. | 2001 Nov 1 |
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[Genetic control of hepatocarcinogenesis in mice]. | 2001 Oct |
|
Immunohistochemical characterization of hepatoblastomas in B6C3F1 mice treated with diethylnitrosamine and sodium phenobarbital. | 2001 Oct |
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Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters. | 2001 Oct |
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Cell type-specific induction of O6-alkylguanine-DNA alkyltransferase mRNA expression in rat liver during regeneration, inflammation and preneoplasia. | 2001 Oct |
|
Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis. | 2001 Oct |
|
Inheritance of resistance to promotion of preneoplastic liver lesions in Copenhagen rats. | 2001 Oct |
|
Effect of alpha-tocopherol on hepatocarcinogenesis in transforming growth factor-alpha (TGF-alpha) transgenic mice treated with diethylnitrosamine. | 2001 Sep |
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Diethylnitrosamine causes pituitary damage, disturbs hormone levels, and reduces sexual dimorphism of certain liver functions in the rat. | 2001 Sep |
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Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16(Ink4a), p19(Arf), p53, and p21(Waf1/Cip1). | 2001 Sep |
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Matrix metalloproteinases-2 and 9 do not play a role in the growth of preneoplastic liver lesions in F344 rats. | 2001 Sep |
|
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis. | 2001 Sep 15 |
|
Strain variation in renal carcinogenesis by N-ethyl-N-hydroxyethylnitrosamine in F1 (Wistar-Fischer) rats. | 2001 Sep 20 |
|
Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM. | 2001 Sep-Oct |
|
Summation of initiation activities in the liver after partial hepatectomy. | 2002 Feb 8 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Thu Jul 06 03:16:32 UTC 2023
by
admin
on
Thu Jul 06 03:16:32 UTC 2023
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Record UNII |
3IQ78TTX1A
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C45398
Created by
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IARC | <i>N</i>-Nitrosodiethylamine |
Code System | Code | Type | Description | ||
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200-226-1
Created by
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34873
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1466652
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C29827
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55-18-5
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5921
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3IQ78TTX1A
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PRIMARY | |||
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4001
Created by
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DTXSID2021028
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M7993
Created by
admin on Thu Jul 06 03:16:33 UTC 2023 , Edited by admin on Thu Jul 06 03:16:33 UTC 2023
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PRIMARY | Merck Index | ||
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N-Nitrosodiethylamine
Created by
admin on Thu Jul 06 03:16:33 UTC 2023 , Edited by admin on Thu Jul 06 03:16:33 UTC 2023
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132
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Related Record | Type | Details | ||
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PARENT -> IMPURITY |
Acceptable intake level of NDEA in ppm.
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Probable human carcinogen.
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PARENT -> IMPURITY |
Probable human carcinogen.
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Probable human carcinogen.
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PARENT -> IMPURITY |
Probable human carcinogen.
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PARENT -> IMPURITY |
Probable human carcinogen.
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PARENT -> IMPURITY |
Probable human carcinogen.
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PARENT -> IMPURITY |
Probable human carcinogen.
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