Details
Stereochemistry | ACHIRAL |
Molecular Formula | C4H10N2O |
Molecular Weight | 102.135 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(CC)N=O
InChI
InChIKey=WBNQDOYYEUMPFS-UHFFFAOYSA-N
InChI=1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
Molecular Formula | C4H10N2O |
Molecular Weight | 102.135 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
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Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation. | 1999 Aug |
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Mutagenicity of nitrosamines in methyltransferase-deficient strains of Salmonella typhimurium coexpressing human cytochrome P450 2E1 and reductase. | 2000 Nov 6 |
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Ovarian tumors in rats induced by chronic 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment. | 2000 Oct 1 |
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Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase. | 2001 |
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Vitamin A and all-trans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats. | 2001 |
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Nitric oxide synthase inhibitors reduced lipid peroxidation in N-nitrosodiethylamine-treated rats. | 2001 |
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Nuclear Ras: unexpected subcellular distribution of oncogenic forms. | 2001 |
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Mutagen sensitivity of nasopharyngeal cancer patients. | 2001 Apr 5 |
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Hepatocellular expression of a dominant-negative mutant TGF-beta type II receptor accelerates chemically induced hepatocarcinogenesis. | 2001 Aug 16 |
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Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats. | 2001 Dec |
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Cytochrome b(5) coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium. | 2001 Dec 12 |
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Alterations of the transforming growth factor-beta signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats. | 2001 Jan |
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Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12. | 2001 Jan |
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Induction of hepatic 8-oxo-deoxyguanosine adducts by 2,3,7,8-tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats is female-specific and estrogen-dependent. | 2001 Jul |
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Preventive effect of FK143, a 5alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats. | 2001 Jul |
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Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. | 2001 Jun |
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Involvement of gap junctions in tumor suppression: analysis of genetically-manipulated mice. | 2001 Jun 2 |
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Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies. | 2001 Jun 2 |
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Liposome encapsulated tumor-associated antigens elicited humoral and cellular immune responses in mice bearing tumor. | 2001 Mar |
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Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carcinoma. | 2001 Mar |
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Effect of selenium on N-nitrosodiethylamine-induced multistage hepatocarcinogenesis with reference to lipid peroxidation and enzymic antioxidants. | 2001 Mar |
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Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade. | 2001 Mar 1 |
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Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population. | 2001 Mar 20 |
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Specific genomic alterations in rat renal cell carcinomas induced by N-ethyl-N-hydroxyethylnitrosamine. | 2001 Mar-Apr |
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DNA damage induced by red food dyes orally administered to pregnant and male mice. | 2001 May |
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Expression profiling and identification of novel genes in hepatocellular carcinomas. | 2001 May 10 |
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An in vivo method for using 5-bromo-2'-deoxyuridine (BrdU) as a marker of chemically-induced hepatocellular proliferation in the Japanese medaka (Oryzias latipes). | 2001 May-Jun |
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The polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline lacks liver tumor initiating and promoting activity in rats exposed to human-relevant doses. | 2001 Nov |
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Organotropic chemopreventive effects of n-3 unsaturated fatty acids in a rat multi-organ carcinogenesis model. | 2001 Nov |
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Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. | 2001 Nov 22 |
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[Genetic control of hepatocarcinogenesis in mice]. | 2001 Oct |
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Inheritance of resistance to promotion of preneoplastic liver lesions in Copenhagen rats. | 2001 Oct |
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Effect of alpha-tocopherol on hepatocarcinogenesis in transforming growth factor-alpha (TGF-alpha) transgenic mice treated with diethylnitrosamine. | 2001 Sep |
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Diethylnitrosamine causes pituitary damage, disturbs hormone levels, and reduces sexual dimorphism of certain liver functions in the rat. | 2001 Sep |
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Matrix metalloproteinases-2 and 9 do not play a role in the growth of preneoplastic liver lesions in F344 rats. | 2001 Sep |
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Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis. | 2001 Sep 15 |
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Strain variation in renal carcinogenesis by N-ethyl-N-hydroxyethylnitrosamine in F1 (Wistar-Fischer) rats. | 2001 Sep 20 |
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Summation of initiation activities in the liver after partial hepatectomy. | 2002 Feb 8 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:06:41 GMT 2025
by
admin
on
Mon Mar 31 20:06:41 GMT 2025
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Record UNII |
3IQ78TTX1A
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Record Status |
Validated (UNII)
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Record Version |
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Systematic Name | English | ||
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C45398
Created by
admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
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IARC | <i>N</i>-Nitrosodiethylamine |
Code System | Code | Type | Description | ||
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200-226-1
Created by
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34873
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1466652
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C29827
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55-18-5
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300000053432
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5921
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3IQ78TTX1A
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4001
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DTXSID2021028
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PRIMARY | |||
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m7993
Created by
admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
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PRIMARY | Merck Index | ||
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N-Nitrosodiethylamine
Created by
admin on Mon Mar 31 20:06:41 GMT 2025 , Edited by admin on Mon Mar 31 20:06:41 GMT 2025
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132
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Related Record | Type | Details | ||
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METABOLIC ENZYME -> SUBSTRATE |
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METABOLIC ENZYME -> SUBSTRATE |
Activates to genotoxic metabolite
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Related Record | Type | Details | ||
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METABOLITE TOXIC -> PARENT |
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METABOLITE TOXIC -> PARENT |
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Related Record | Type | Details | ||
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PARENT -> IMPURITY |
Acceptable intake level of NDEA in ppm.
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PARENT -> IMPURITY |
Probable human carcinogen.
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PARENT -> IMPURITY |
Probable human carcinogen.
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PARENT -> IMPURITY |
Probable human carcinogen.
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PARENT -> IMPURITY |
Probable human carcinogen.
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PARENT -> IMPURITY |
Probable human carcinogen.
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PARENT -> IMPURITY |
Probable human carcinogen.
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PARENT -> IMPURITY |
Probable human carcinogen.
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