Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C75H124N14O16.C2HF3O2 |
Molecular Weight | 1591.8946 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 17 / 17 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C(F)(F)F.[H][C@](NC(=O)[C@H](NC(=O)CC[C@@H](C)CC)C(C)C)([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N1CCC[C@]1([H])C(=O)N[C@@H](CCCN)C(=O)N[C@]([H])([C@@H](C)CC)C(=O)N[C@@H]2[C@@H](C)OC(=O)[C@@H](NC(=O)\C(NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](NC(=O)[C@]([H])(NC2=O)[C@@H](C)CC)C(C)C)=C\C)C(C)C
InChI
InChIKey=FUDHRLIJYPGBOX-MWGCIELCSA-N
InChI=1S/C75H124N14O16.C2HF3O2/c1-20-43(15)33-34-53(91)80-54(38(5)6)68(97)87-61(46(18)90)72(101)82-56(40(9)10)69(98)83-57(41(11)12)74(103)89-36-28-32-52(89)66(95)78-50(31-27-35-76)64(93)85-59(44(16)21-2)71(100)88-62-47(19)105-75(104)58(42(13)14)84-63(92)49(23-4)77-65(94)51(37-48-29-25-24-26-30-48)79-67(96)55(39(7)8)81-70(99)60(45(17)22-3)86-73(62)102;3-2(4,5)1(6)7/h23-26,29-30,38-47,50-52,54-62,90H,20-22,27-28,31-37,76H2,1-19H3,(H,77,94)(H,78,95)(H,79,96)(H,80,91)(H,81,99)(H,82,101)(H,83,98)(H,84,92)(H,85,93)(H,86,102)(H,87,97)(H,88,100);(H,6,7)/b49-23-;/t43-,44-,45-,46+,47+,50-,51-,52+,54+,55+,56-,57+,58-,59+,60+,61-,62+;/m0./s1
Molecular Formula | C75H124N14O16 |
Molecular Weight | 1477.8713 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 17 / 17 |
E/Z Centers | 6 |
Optical Activity | UNSPECIFIED |
Molecular Formula | C2HF3O2 |
Molecular Weight | 114.0233 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Elisidepsin (Irvalec®, PM02734) is a depsipeptide produced by chemical synthesis and chosen for development as an antineoplastic agent based on its in vitro activity against human solid tumor cell lines, in vivo activity in hollow fibers and xenografted human tumors, as well as its acceptable preclinical toxicology profile. Elisidepsin causes a typical necrotic cell death and induces profound alterations in tumor cell morphology. Elisidepsin inserts into the plasma membrane causing rapid loss of integrity and necrotic cell death in tumor cells. PharmaMar was developing elisidepsin for the treatment of cancer. However, development of the compound has been suspended.
Originator
Approval Year
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23519149
Elisidepsin showed potent and broad cytotoxic effects in a cancer cell line panel, being active at concentrations ranging from 0.4 to 2 μM that may be relevant for clinical settings.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:58:43 GMT 2023
by
admin
on
Sat Dec 16 09:58:43 GMT 2023
|
Record UNII |
3I37B5DY4Q
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
46926348
Created by
admin on Sat Dec 16 09:58:43 GMT 2023 , Edited by admin on Sat Dec 16 09:58:43 GMT 2023
|
PRIMARY | |||
|
3I37B5DY4Q
Created by
admin on Sat Dec 16 09:58:43 GMT 2023 , Edited by admin on Sat Dec 16 09:58:43 GMT 2023
|
PRIMARY | |||
|
915713-02-9
Created by
admin on Sat Dec 16 09:58:43 GMT 2023 , Edited by admin on Sat Dec 16 09:58:43 GMT 2023
|
PRIMARY | |||
|
m4871
Created by
admin on Sat Dec 16 09:58:43 GMT 2023 , Edited by admin on Sat Dec 16 09:58:43 GMT 2023
|
PRIMARY | Merck Index | ||
|
DB05158
Created by
admin on Sat Dec 16 09:58:43 GMT 2023 , Edited by admin on Sat Dec 16 09:58:43 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> SALT/SOLVATE | |||
|
PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |