Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2Na.O2 |
| Molecular Weight | 77.9783 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[O-][O-]
InChI
InChIKey=PFUVRDFDKPNGAV-UHFFFAOYSA-N
InChI=1S/2Na.O2/c;;1-2/q2*+1;-2
| Molecular Formula | O2 |
| Molecular Weight | 31.9988 |
| Charge | -2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Hydrogen peroxide has been used in medicine for more than 100 years. It is known in surgery as a highly useful irrigation solution by virtue of both its hemostatic and its antimicrobial effects. Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis). This product works by releasing oxygen when it is applied to the affected area. The release of oxygen causes foaming, which helps to remove dead skin and clean the area. Hydrogen peroxide is a strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: GO:0016491 |
|||
Target ID: O94759 Gene ID: 7226.0 Gene Symbol: TRPM2 Target Organism: Homo sapiens (Human) |
4.54 null [pEC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | ESKATA Approved UseESKATA is indicated for the treatment of seborrheic keratoses that are raised. Launch Date2017 |
|||
| Preventing | Hydrogen Peroxide Solution Approved UseUses of Hydrogen Peroxide Solution:
It is used to prevent skin infections.
It is used to help get rid of phlegm or mucus or help with a sore mouth. |
|||
| Primary | Hydrogen Peroxide Solution Approved UseHydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis). Launch Date1982 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). | 2002-10-25 |
|
| Reactive oxygen species stimulated human hepatoma cell proliferation via cross-talk between PI3-K/PKB and JNK signaling pathways. | 2002-10-15 |
|
| Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species. | 2002-10 |
|
| Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. | 2002-09-30 |
|
| Iron augments stage-I and stage-II tumor promotion in murine skin. | 2002-09-26 |
|
| The antioxidant cocktail effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro. | 2002-09-06 |
|
| Is calcineurin a peroxide-specific sensor in T-lymphocytes? | 2002-09 |
|
| An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. | 2002-08-15 |
|
| D-penicillamine cooperates with copper sulfate to enhance the surface expression of functional Fas antigen in rheumatoid synovial fibroblasts via the generation of hydrogen peroxide. | 2002-08-15 |
|
| Doxorubicin-induced apoptosis: implications in cardiotoxicity. | 2002-08-07 |
|
| Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells. | 2002-08-01 |
|
| High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells. | 2002-08 |
|
| Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. | 2002-07-15 |
|
| Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. | 2002-07 |
|
| Overexpression of human metallothionein-III prevents hydrogen peroxide-induced oxidative stress in human fibroblasts. | 2002-06-19 |
|
| Reversible inactivation of the tumor suppressor PTEN by H2O2. | 2002-06-07 |
|
| Menadione biphasically controls JNK-linked cell death in leukemia Jurkat T cells. | 2002-06 |
|
| Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors. | 2002-06 |
|
| Differential expression of two stress-inducible hsp70 genes by various stressors. | 2002-05-31 |
|
| Expression of rat liver glutathione-S-transferase GSTA5 in cell lines provides increased resistance to alkylating agents and toxic aldehydes. | 2002-05-20 |
|
| Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway. | 2002-05 |
|
| Role of reactive oxygen species and NAD(P)H oxidase in alpha(1)-adrenoceptor signaling in adult rat cardiac myocytes. | 2002-04 |
|
| Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase. | 2002-03 |
|
| Glucose-6-phosphate dehydrogenase: the key to sex-related xenobiotic toxicity in hepatocytes of European flounder (Platichthys flesus L.)? | 2002-03 |
|
| Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth. | 2002-02-15 |
|
| Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells. | 2002-01-05 |
|
| Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. | 2001-12-21 |
|
| Chromium chloride inhibits oxidative stress and TNF-alpha secretion caused by exposure to high glucose in cultured U937 monocytes. | 2001-12-07 |
|
| NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells. | 2001-12-01 |
|
| DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin. | 2001-12 |
|
| Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. | 2001-12 |
|
| Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein. | 2001-11-30 |
|
| Phosphorylation is involved in the activation of metal-regulatory transcription factor 1 in response to metal ions. | 2001-11-09 |
|
| p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line. | 2001-11 |
|
| Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death. | 2001-10-09 |
|
| Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells. | 2001-10 |
|
| Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway. | 2001-10 |
|
| Reactive carbonyl formation by oxidative and non-oxidative pathways. | 2001-08-01 |
|
| Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin. | 2001-08-01 |
|
| Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. | 2001-07-06 |
|
| Human alveolar macrophages and granulocyte-macrophage colony-stimulating factor-induced monocyte-derived macrophages are resistant to H2O2 via their high basal and inducible levels of catalase activity. | 2001-06-29 |
|
| Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells. | 2001-06-15 |
|
| Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant. | 2001-06 |
|
| Repression of phenobarbital-dependent CYP2B1 mRNA induction by reactive oxygen species in primary rat hepatocyte cultures. | 2001-06 |
|
| The influence of oxidative stress on catalase and MnSOD gene transcription in astrocytes. | 2001-05-04 |
|
| Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins. | 2001-05 |
|
| Simultaneous measurement of ERK, p38, and JNK MAP kinase cascades in vascular smooth muscle cells. | 2001-04-28 |
|
| Manganese superoxide dismutase signals matrix metalloproteinase expression via H2O2-dependent ERK1/2 activation. | 2001-04-27 |
|
| Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death. | 2001-04-19 |
|
| Mitochondrial-derived oxidants and quartz activation of chemokine gene expression. | 2001 |
Sample Use Guides
Topical solution: 40% (w/w) hydrogen peroxide. Apply 4 times, approximately 1 minute apart, to the
targeted lesion(s) during a single in-office treatment
session.
Route of Administration:
Topical
Hydrogen peroxide (H2O2, 100-500 uM) caused a concentration-dependent decrease in the activity of recombinant mouse 3-MST enzyme. In mitochondria isolated from murine hepatoma cells, H2O2 (50-500 uM) caused a concentration-dependent decrease in production of H2S from 3-MP. In cultured murine hepatoma cells H2O2, (3-100 uM), did not result in overall cytotoxicity, but caused a partial decrease in basal oxygen consumption and respiratory reserve rapacity. The positive bioenergetic effect of 3-MP (100-300 nM) was completely abolished by pre-treatment of the cells with H2O2 (50 uM).
| Substance Class |
Chemical
Created
by
admin
on
Edited
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| Record UNII |
3GSN3JCJ5K
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| Record Status |
Validated (UNII)
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| Record Version |
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SODIUM SUPEROXIDE
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m10056
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