Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H33FN2O4 |
| Molecular Weight | 443.5415 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(CN(CCCCNC(=O)C3=CC(C)=CC=C3OCC[18F])CC2)C=C1OC
InChI
InChIKey=QVRVXSZKCXFBTE-KPVNRNJOSA-N
InChI=1S/C25H33FN2O4/c1-18-6-7-22(32-13-9-26)21(14-18)25(29)27-10-4-5-11-28-12-8-19-15-23(30-2)24(31-3)16-20(19)17-28/h6-7,14-16H,4-5,8-13,17H2,1-3H3,(H,27,29)/i26-1
| Molecular Formula | C25H33FN2O4 |
| Molecular Weight | 443.5415 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
ISO-1 F-18 is a benzamide analog radiolabeled with 18F. It is a sigma-2 receptor ligand. Since sigma-2 receptor is expressed in higher density in proliferating tumor cells versus quiescent tumor cells, ISO-1 F-18 can be used as a positron emission tomography (PET) tracer to evaluate tumor proliferation by PET in patients with malignant neoplasms. Currently, ISO-1 F-18 in Phase I clinical trial as an investigational radiotracer in primary breast cancer.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:00:00 GMT 2023
by
admin
on
Sat Dec 16 19:00:00 GMT 2023
|
| Record UNII |
3G67X40A29
|
| Record Status |
Validated (UNII)
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| Record Version |
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16737780
Created by
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3G67X40A29
Created by
admin on Sat Dec 16 19:00:01 GMT 2023 , Edited by admin on Sat Dec 16 19:00:01 GMT 2023
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DB14900
Created by
admin on Sat Dec 16 19:00:01 GMT 2023 , Edited by admin on Sat Dec 16 19:00:01 GMT 2023
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945992-47-2
Created by
admin on Sat Dec 16 19:00:01 GMT 2023 , Edited by admin on Sat Dec 16 19:00:01 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET->RADIOLIGAND | |||
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NON-LABELED -> LABELED |
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ACTIVE MOIETY |
