PEGTIBATINASE

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 01:01:02 GMT 2025` Edited by `admin` on `Wed Apr 02 01:01:02 GMT 2025`
Protein Type	ENZYME
Protein Sub Type	PEGYLATED PROTEIN
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	3G3529LUQ7
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

OT-58

Preferred Name

English

PEGTIBATINASE

Official Name

English

pegtibatinase [INN]

Common Name

English

TVT-058

Code

English

PEGTIBATINASE [USAN]

Common Name

English

20NHS PEG-CBS

Common Name

English

2-413-CYSTATHIONINE .BETA.-SYNTHASE (15-SERINE) (RECOMBINANT HUMAN CLONE OT-58), PEGYLATED

Common Name

English

OT-58 (PEGYLATED HUMAN TRUNCATED CYSTATHIONINE BETASYNTHASE (CBS))

Common Name

English

HUMAN CYSTATHIONINE .BETA.-SYNTHASE FRAGMENT (2-413, M1 CLEAVED) MUTANT (C15>S), HOMODIMER, PRODUCED IN ESCHERICHIA COLI, PEGYLATED AT N6 OF LYSINE RESIDUES WITH AN AVERAGE OF FIVE 5-(.ALPHA.-METHYLPOLY(OXYETHYLENE)-.OMEGA.-OXY)-5-OXOPENTANOYL GROUPS PER

Common Name

English

20NHS PEG-CBS (FIVE PEG CHAINS RESIDUES PER SUBUNIT ATTACHED TO MULTIPLE LYSINES ACROSS THE ENTIRE PROTEIN SEQUENCE)

Common Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/16/1664

Created by admin on Wed Apr 02 01:01:02 GMT 2025 , Edited by admin on Wed Apr 02 01:01:02 GMT 2025

Code System Code Type Description

FDA UNII

3G3529LUQ7

Created by admin on Wed Apr 02 01:01:02 GMT 2025 , Edited by admin on Wed Apr 02 01:01:02 GMT 2025

PRIMARY

INN

11414

Created by admin on Wed Apr 02 01:01:02 GMT 2025 , Edited by admin on Wed Apr 02 01:01:02 GMT 2025

PRIMARY

USAN

JK-179

Created by admin on Wed Apr 02 01:01:02 GMT 2025 , Edited by admin on Wed Apr 02 01:01:02 GMT 2025

PRIMARY

CAS

2304692-47-3

Created by admin on Wed Apr 02 01:01:02 GMT 2025 , Edited by admin on Wed Apr 02 01:01:02 GMT 2025

PRIMARY

SMS_ID

100000182979

Created by admin on Wed Apr 02 01:01:02 GMT 2025 , Edited by admin on Wed Apr 02 01:01:02 GMT 2025

PRIMARY

NCI_THESAURUS

C175837

Created by admin on Wed Apr 02 01:01:02 GMT 2025 , Edited by admin on Wed Apr 02 01:01:02 GMT 2025

PRIMARY

Related Record Type Details


					0LVT1QZ0BA

SUBSTRATE -> TARGET

Amount:


					D2BEN9A4GU

CYSTATHIONINE BETA-SYNTHASE

TARGET->ENZYME REPLACEMENT

Amount:

Related Record Type Details


					3G3529LUQ7

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
PEGYLATION	CONJUGATION	PEGYLATION REAGENT		MPEG-450 GLUTARATE N-HYDROXYSUCCIMIDE	12PMF3DED0

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC		Amount:	M-PEG-20000 N6-GLUTARIMIDE-LYSINE	8U9E9W8I2M

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL
Molecular Formula	CHEMICAL