| Stereochemistry | ACHIRAL |
| Molecular Formula | C34H45N3O |
| Molecular Weight | 511.7406 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCN(CC1=CC=C(C=C1)C2=CC=C(CNCCC3=CC=CC=C3)C=C2)C(=O)CCC4CCCC4
InChI
InChIKey=SEQAMPXQRKYYQF-UHFFFAOYSA-N
InChI=1S/C34H45N3O/c1-36(2)24-25-37(34(38)21-16-28-10-6-7-11-28)27-31-14-19-33(20-15-31)32-17-12-30(13-18-32)26-35-23-22-29-8-4-3-5-9-29/h3-5,8-9,12-15,17-20,28,35H,6-7,10-11,16,21-27H2,1-2H3
| Molecular Formula | C34H45N3O |
| Molecular Weight | 511.7406 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
SB-699551 is the first selective serotonin 5A receptor antagonist. SB-699551 showed an anxiolytic-like property in animal model. It demostrated efficacy against schizophrenia-like cognitive deficits and negative symptoms in rats. Blockade of 5-HT5A receptor with SB-699551 appear to be able to impair the consolidation of memory in rodents. In addition, 5-HT-induced spinal antinociception in the capsaicin and acetic acid tests was blocked by SB-699551.
CNS Activity
Originator
Approval Year
PubMed
Patents
Sample Use Guides
guinea pigs: 0.3, 1 or 3 mg/kg s.c.
rodents: 1-60 mg/kg, i.p.
Route of Administration:
Other
In guinea pig dorsal raphe slices, SB-699551-A (1 uM) did not alter neuronal firing per se but attenuated the 5-carboxamidotryptamine-induced depression in serotonergic neuronal firing in a subpopulation of cells insensitive to the 5-HT1A receptor-selective antagonist WAY-100635 (100 nM).
