Lerepmeran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 11:55:50 GMT 2025` Edited by `admin` on `Wed Apr 02 11:55:50 GMT 2025`
Nucleic Acid Type	MRNA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	3DMH5L9FB8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CX-032064

Preferred Name

English

Lerepmeran

Official Name

English

messenger RNA (mRNA), 5'(m7G-(5'?5')-ppp-Gm)-capped, encoding codon-optimised human propionyl-CoA carboxylase subunit alpha (PCCA), flanked by 5' and 3' untranslated regions (UTRs), followed by a 3' polyadenylation (polyA) tail and concluded by a 5-nucle

Common Name

English

RNA (recombinant 5?-(m7G-(5??5?)-ppp-Gm)-capped all uridine?N1-methylpseudouridine-substituted 5?-untranslated region plus human propionyl-CoA carboxylase ? subunit plus 3?-untranslated region-containing microRNA-142 binding sites plus poly(A)-tailed mes

Common Name

English

lerepmeran [INN]

Common Name

English

Code System Code Type Description

INN

13181

Created by admin on Wed Apr 02 11:55:50 GMT 2025 , Edited by admin on Wed Apr 02 11:55:50 GMT 2025

PRIMARY

CAS

2924731-63-3

Created by admin on Wed Apr 02 11:55:50 GMT 2025 , Edited by admin on Wed Apr 02 11:55:50 GMT 2025

PRIMARY

FDA UNII

3DMH5L9FB8

Created by admin on Wed Apr 02 11:55:50 GMT 2025 , Edited by admin on Wed Apr 02 11:55:50 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_2525	2525 / 2525

Linkage	Site Range	Site Count
Phosphate	1_2-1_2525	2524 / 2524

Related Record Type Details


					8J6VZW2DCE

PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					3DMH5L9FB8

Lerepmeran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION		RESIDUE_SPECIFIC	U		N1-METHYLPSEUDOURIDINE	09RAD4M6WF
NUCLEOTIDE SUBSTITUTION		5'-TERMINUS	A		7M-G-PPP-2'M-A-P MRNA CAP	P7W5ZN6FY2

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
OFR	NUCLEIC ACID FEATURE

microRNA-142 (miR-142) binding sites	NUCLEIC ACID FEATURE

5'-UTR	NUCLEIC ACID FEATURE

Poly (A)	NUCLEIC ACID FEATURE