Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H5ClO |
Molecular Weight | 128.556 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=C(Cl)C=C1
InChI
InChIKey=WXNZTHHGJRFXKQ-UHFFFAOYSA-N
InChI=1S/C6H5ClO/c7-5-1-3-6(8)4-2-5/h1-4,8H
Molecular Formula | C6H5ClO |
Molecular Weight | 128.556 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/5270931https://www.researchgate.net/publication/253349096_p-Chlorophenoxyacetic_acid_-_Preparation_of_a_synthetic_plant_hormone | http://www.guidechem.com/reference/dic-371673.htmlCurator's Comment: Description was created based on several sources, including
http://drugs-about.com/drugs-e/endotine.html and http://www.ncbi.nlm.nih.gov/pubmed/1337555
Sources: http://www.ncbi.nlm.nih.gov/pubmed/5270931https://www.researchgate.net/publication/253349096_p-Chlorophenoxyacetic_acid_-_Preparation_of_a_synthetic_plant_hormone | http://www.guidechem.com/reference/dic-371673.html
Curator's Comment: Description was created based on several sources, including
http://drugs-about.com/drugs-e/endotine.html and http://www.ncbi.nlm.nih.gov/pubmed/1337555
Since 4-chlorophenol is caustic, toxic, and fairly difficult to dispense because it has s melting point of 43% it is convenient to run the reaction of synthesis of p-chlorophenoxyacetic acid for preparation of a synthetic plant hormone using a stock solution that is 1.0 M sodium 4-chlorophenolate and 2.5 M sodium hydroxide. Addition of ehloroacetic acid (CI-CH2C02H) to this solution gives the chloroacetate anion (VIII).
sodium 4-chlorophenolate is a local antibacterial agent in root canal therapy. It is also used as topical antiseptic, formerly used as topical antiseptic in ointments.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: GO:0002281 Sources: http://www.ncbi.nlm.nih.gov/pubmed/9487846 |
|||
Target ID: Enterococcus faecalis growth Sources: http://www.ncbi.nlm.nih.gov/pubmed/9590928 |
|||
Target ID: Porphyromonus gingivalis growth Sources: http://www.ncbi.nlm.nih.gov/pubmed/1337555 |
|||
Target ID: Fusobacterium nucleatum growth Sources: http://www.ncbi.nlm.nih.gov/pubmed/1337555 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Curative | Endotine Approved UseRoot canal antiseptic |
PubMed
Title | Date | PubMed |
---|---|---|
Urinary excretion of chlorinated phenols in saw-mill workers. | 1991 |
|
Degradation of 2,3,4,6-tetrachlorophenol at low temperature and low dioxygen concentrations by phylogenetically different groundwater and bioreactor bacteria. | 2001 |
|
Toxicity of mono-, di- and tri-chlorophenols to lux marked terrestrial bacteria, Burkholderia species Rasc c2 and Pseudomonas fluorescens. | 2001 Apr |
|
Tetrachloroethylene, trichloroethylene, and chlorinated phenols induce toluene-o-xylene monooxygenase activity in Pseudomonas stutzeri OX1. | 2001 Aug |
|
The spinning disc reactor--studies on a novel TiO2 photocatalytic reactor. | 2001 Feb |
|
Purification and catalytic properties of the chlorophenol 4-monooxygenase from Burkholderia cepacia strain AC1100. | 2001 Jun 11 |
|
Microstructure determination of AOT + phenol organogels utilizing small-angle X-ray scattering and atomic force microscopy. | 2001 Mar 14 |
|
Development of an element-selective monitoring system for adsorbable organic halogens (AOX) with plasma emission spectrometric detection for quasi-continuous waste-water analysis. | 2001 Nov |
|
Adsorption of phenol and m-chlorophenol on organobentonites and repeated thermal regeneration. | 2002 |
|
[Prophylactic efficiency of tietasol and oxymethyluracyl against chlorphenols exposure in experimental and real conditions]. | 2002 |
|
Adsorption of phenols by papermill sludges. | 2002 |
|
Variation of toxicity during the ozonation of monochlorophenolic solutions. | 2002 |
|
Photochemical behaviour of dichlorprop [(+/-)-2-(2,4-dichlorophenoxy)propanoic acid] in aqueous solution. | 2002 Aug |
|
Reversed flow injection spectrophotometric determination of low residuals of chlorine dioxide in water using chlorophenol red. | 2002 Jul |
|
Substrate-dependent autoaggregation of Pseudomonas putida CP1 during the degradation of mono-chlorophenols and phenol. | 2002 Jun |
|
Spatial distibution and temporal accumulation of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in the Gulf of Finland. | 2002 Jun 15 |
|
Kinetic studies on UV-photodegradation of some chlorophenols using TiO2 catalyst. | 2002 Mar |
|
Photocatalytic degradation of aqueous 4-chlorophenol by silica-immobilized polyoxometalates. | 2002 Mar 15 |
|
Concentration of chlorophenols in water with sodium dodecylsulfate-gamma-alumina admicelles for high-performance liquid chromatographic analysis. | 2002 Oct 4 |
|
Detoxification of phenolic solutions with horseradish peroxidase and hydrogen peroxide. | 2002 Sep |
|
Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line. | 2002 Sep 3 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://www.doctissimo.fr/medicament-ENDOTINE.htm
Unknown
Route of Administration:
Dental
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/10726519
0.01 mM of camphorated parachlorophenol (parachlorophenol) inhibited periodontal ligament cells proliferation, as shown by [3H]thymidine incorporation.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 14:57:52 GMT 2023
by
admin
on
Fri Dec 15 14:57:52 GMT 2023
|
Record UNII |
3DLC36A01X
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Official Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C28394
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
C87268
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
DB13154
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
1496802
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
203-402-6
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
CHEMBL57053
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
C029107
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
2877
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
14982
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | RxNorm | ||
|
DTXSID1021871
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
106-48-9
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
m3427
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | Merck Index | ||
|
1414
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
28078
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
4-Chlorophenol
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
3DLC36A01X
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
SUB55726
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
4684
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY | |||
|
100000133835
Created by
admin on Fri Dec 15 14:57:52 GMT 2023 , Edited by admin on Fri Dec 15 14:57:52 GMT 2023
|
PRIMARY |