Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H5ClO |
| Molecular Weight | 128.556 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=C(Cl)C=C1
InChI
InChIKey=WXNZTHHGJRFXKQ-UHFFFAOYSA-N
InChI=1S/C6H5ClO/c7-5-1-3-6(8)4-2-5/h1-4,8H
| Molecular Formula | C6H5ClO |
| Molecular Weight | 128.556 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/5270931https://www.researchgate.net/publication/253349096_p-Chlorophenoxyacetic_acid_-_Preparation_of_a_synthetic_plant_hormone | http://www.guidechem.com/reference/dic-371673.htmlCurator's Comment: Description was created based on several sources, including
http://drugs-about.com/drugs-e/endotine.html and http://www.ncbi.nlm.nih.gov/pubmed/1337555
Sources: http://www.ncbi.nlm.nih.gov/pubmed/5270931https://www.researchgate.net/publication/253349096_p-Chlorophenoxyacetic_acid_-_Preparation_of_a_synthetic_plant_hormone | http://www.guidechem.com/reference/dic-371673.html
Curator's Comment: Description was created based on several sources, including
http://drugs-about.com/drugs-e/endotine.html and http://www.ncbi.nlm.nih.gov/pubmed/1337555
Since 4-chlorophenol is caustic, toxic, and fairly difficult to dispense because it has s melting point of 43% it is convenient to run the reaction of synthesis of p-chlorophenoxyacetic acid for preparation of a synthetic plant hormone using a stock solution that is 1.0 M sodium 4-chlorophenolate and 2.5 M sodium hydroxide. Addition of ehloroacetic acid (CI-CH2C02H) to this solution gives the chloroacetate anion (VIII).
sodium 4-chlorophenolate is a local antibacterial agent in root canal therapy. It is also used as topical antiseptic, formerly used as topical antiseptic in ointments.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: GO:0002281 |
|||
Target ID: Enterococcus faecalis growth |
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Target ID: Porphyromonus gingivalis growth |
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Target ID: Fusobacterium nucleatum growth |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
|||
| Curative | Endotine Approved UseRoot canal antiseptic |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Degradation of 2,3,4,6-tetrachlorophenol at low temperature and low dioxygen concentrations by phylogenetically different groundwater and bioreactor bacteria. | 2001 |
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| Adsorption of phenol and m-chlorophenol on organobentonites and repeated thermal regeneration. | 2002 |
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| [Prophylactic efficiency of tietasol and oxymethyluracyl against chlorphenols exposure in experimental and real conditions]. | 2002 |
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| Adsorption of phenols by papermill sludges. | 2002 |
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| Sonochemical degradation of aromatic organic pollutants. | 2002 |
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| Successive rapid reductive dehalogenation and mineralization of pentachlorophenol by the indigenous microflora of farmyard manure compost. | 2002 |
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| Variation of toxicity during the ozonation of monochlorophenolic solutions. | 2002 |
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| Detection of insulin-regulated GLUT4-translocation by the insertion of a protein C epitope in L6 myoblasts. | 2002 Apr 18 |
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| Evaluation of interactive toxicity of chlorophenols in water and soil using lux-marked biosensors. | 2002 Aug |
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| Photochemical behaviour of dichlorprop [(+/-)-2-(2,4-dichlorophenoxy)propanoic acid] in aqueous solution. | 2002 Aug |
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| Lethal body residue of chlorophenols and mixtures of chlorophenols in benthic organisms. | 2002 Aug |
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| Increased activity of in situ catalysts for alkyne metathesis. | 2002 Aug 22 |
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| COX-2 selective inhibition reverses the trophic properties of gastrin in colorectal cancer. | 2002 Aug 27 |
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| Effects of parachlorophenol and camphorated parachlorophenol on the phagocytic activities of a murine macrophage cell line (RAW264.7). | 2002 Dec |
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| Kinetics of phenol and chlorophenol utilization by Acinetobacter species. | 2002 Feb |
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| Electrochemical oxidation of chlorophenols at a boron-doped diamond electrode and their determination by high-performance liquid chromatography with amperometric detection. | 2002 Feb 15 |
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| Reversed flow injection spectrophotometric determination of low residuals of chlorine dioxide in water using chlorophenol red. | 2002 Jul |
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| Electrochemical removal of p-nonylphenol from dilute solutions using a carbon fiber anode. | 2002 Jul |
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| Effects of 2,4-dichlorophenol on activated sludge. | 2002 Jul |
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| Validated method for quantitation of biomarkers for benzene and its alkylated analogues in urine. | 2002 Jul 15 |
|
| Acute toxicity of crude and dispersed oil to Octopus pallidus (Hoyle, 1885) hatchlings. | 2002 Jun |
|
| Adsorption of phenolic compounds from aqueous solutions by a water-compatible hypercrosslinked polymeric adsorbent. | 2002 Jun |
|
| Kinetic modeling of fenton oxidation of phenol and monochlorophenols. | 2002 Jun |
|
| Acute lethal toxicity of environmental pollutants to aquatic organisms. | 2002 Jun |
|
| Substrate-dependent autoaggregation of Pseudomonas putida CP1 during the degradation of mono-chlorophenols and phenol. | 2002 Jun |
|
| Porous polysilsesquioxanes for the adsorption of phenols. | 2002 Jun 1 |
|
| Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro. | 2002 Jun 14 |
|
| Spatial distibution and temporal accumulation of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in the Gulf of Finland. | 2002 Jun 15 |
|
| [Degradation of 4-chlorophenol in aqueous solution by high-voltage pulsed discharge-ozone technology]. | 2002 Mar |
|
| Radical/radical vs radical/molecule reactions in the formation of PCDD/Fs from (chloro)phenols in incinerators. | 2002 Mar |
|
| Kinetic studies on UV-photodegradation of some chlorophenols using TiO2 catalyst. | 2002 Mar |
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| Photocatalytic degradation of aqueous 4-chlorophenol by silica-immobilized polyoxometalates. | 2002 Mar 15 |
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| Adsorption of p-chlorophenol from aqueous solutions on bentonite and perlite. | 2002 Mar 29 |
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| A portable toxicity biosensor using freeze-dried recombinant bioluminescent bacteria. | 2002 May |
|
| Case-control study evaluating the homogeneity and heterogeneity of risk factors between sinonasal and nasopharyngeal cancers. | 2002 May 1 |
|
| Dimethyl sulfoxide blocks herpes simplex virus-1 productive infection in vitro acting at different stages with positive cooperativity. Application of micro-array analysis. | 2002 May 24 |
|
| Solar photocatalysis: a clean process for water detoxification. | 2002 May 27 |
|
| Identification of 2,4-dichlorophenol in females of the American dog tick, Dermacentor variabilis (Acari: Ixodidae), and its possible role as a component of the attractant sex pheromone. | 2002 Nov |
|
| Separation and determination of phenolic compounds by capillary electrophoresis with chemiluminescence detection. | 2002 Nov 29 |
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| Thermodynamic study of adsorption of phenolic compounds onto Amberlite XAD-4 polymeric adsorbents and its acetylized derivative MX-4. | 2002 Oct |
|
| Cis/trans isomerisation of unsaturated fatty acids in a cardiolipin synthase knock-out mutant of Pseudomonas putida P8. | 2002 Oct |
|
| Development of supercritical fluid extraction with a solid-phase trapping for fast estimation of toxic load of polychlorinated dibenzo-p-dioxins-dibenzofurans in sawmill soil. | 2002 Oct 25 |
|
| The role of hydrogen bonding on the h-atom-donating abilities of catechols and naphthalene diols and on a previously overlooked aspect of their infrared spectra. | 2002 Oct 30 |
|
| Concentration of chlorophenols in water with sodium dodecylsulfate-gamma-alumina admicelles for high-performance liquid chromatographic analysis. | 2002 Oct 4 |
|
| Detoxification of phenolic solutions with horseradish peroxidase and hydrogen peroxide. | 2002 Sep |
|
| Expression of beta-galactosidase by recombinant respiratory syncytial viruses for microneutralization assay. | 2002 Sep |
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| Degradation of 4-chlorophenol by the white rot fungus Phanerochaete chrysosporium in free and immobilized cultures. | 2002 Sep |
|
| Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line. | 2002 Sep 3 |
|
| 4-chlorophenol degradation by chloroperoxidase from Caldariomyces fumago: formation of insoluble products. | 2002 Spring |
|
| Simulation of bioremediation of chlorophenols in a sandy aquifer. | 2003 Jan |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 14:57:52 UTC 2023
by
admin
on
Fri Dec 15 14:57:52 UTC 2023
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| Record UNII |
3DLC36A01X
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| Record Status |
Validated (UNII)
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| Record Version |
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C28394
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4-Chlorophenol
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