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Details

Stereochemistry ACHIRAL
Molecular Formula C3H2F6O
Molecular Weight 168.0378
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1,1,1,3,3,3-HEXAFLUOROISOPROPANOL

SMILES

OC(C(F)(F)F)C(F)(F)F

InChI

InChIKey=BYEAHWXPCBROCE-UHFFFAOYSA-N
InChI=1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H

HIDE SMILES / InChI

Molecular Formula C3H2F6O
Molecular Weight 168.0378
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis of selenium analogues of the naturally occurring glycosidase inhibitor salacinol and their evaluation as glycosidase inhibitors.
2002 Jul 17
Ion-pair reversed-phase high-performance liquid chromatography analysis of oligonucleotides: retention prediction.
2002 Jun 7
Characterization of poly(butylene terephthalate) by size-exclusion chromatography and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
2002 Nov 8
Dynamic study of excited state hydrogen-bonded complexes of harmane in cyclohexane-toluene mixtures.
2002 Sep
Determination of hexafluoroisopropanol, a sevoflurane urinary metabolite, by 9-fluorenylmethyl chloroformate derivatization.
2002 Sep 5
Ultrasonic studies of alcohol-induced transconformation in beta-lactoglobulin: the intermediate state.
2003 Dec
Hexafluoroisopropanol and acid destabilized forms of apomyoglobin exhibit structural differences.
2003 Jan 21
Dissolution of beta2-microglobulin amyloid fibrils by dimethylsulfoxide.
2003 Jul
Hydrogen-bonding effects on the properties of phenoxyl radicals. An EPR, kinetic, and computational study.
2003 Jul 9
Structural characterization and artificial fiber formation of Bombyx mori silk fibroin in hexafluoro-iso-propanol solvent system.
2003 Jun
Substituent effects on the ionization reaction of beta-mesylate phenethyl radicals.
2003 Jun 7
Inactivation and conformational changes of creatine kinase at low concentrations of hexafluoroisopropanol solutions.
2003 Oct
Human biomonitoring of pyrethrum and pyrethroid insecticides used indoors: determination of the metabolites E-cis/trans-chrysanthemumdicarboxylic acid in human urine by gas chromatography-mass spectrometry with negative chemical ionization.
2003 Oct 5
Y10W beta(1-40) fluorescence reflects epitope exposure in conformers of Alzheimer's beta-peptide.
2003 Sep 1
Characterization of a partially folded intermediate of papain induced by fluorinated alcohols at low pH.
2004 Dec 1
NMR structures of the C-terminal segment of surfactant protein B in detergent micelles and hexafluoro-2-propanol.
2004 Dec 7
Oligopeptide-mediated acceleration of amyloid fibril formation of amyloid beta(Abeta) and alpha-synuclein fragment peptide (NAC).
2004 Jan
Synthesis of a novel class of sulfonium ions as potential inhibitors of UDP-galactopyranose mutase.
2004 Jan 22
1,1,1,3,3,3-hexafluoroisopropanol induced thermal unfolding and molten globule state of bovine alpha-lactalbumin: calorimetric and spectroscopic studies.
2004 Mar
Human amylin oligomer growth and fibril elongation define two distinct phases in amyloid formation.
2004 Mar 26
Fluoroalcohol-induced stabilization of the alpha-helical intermediates of lentil lectin: implication for non-hierarchical lectin folding.
2004 Nov 15
1,8-bis(diphenylmethylium)naphthalenediyl dication as an organic oxidant: synthesis of benzidines via self-coupling of N,N-dialkylanilines.
2004 Nov 25
Development of an ion-pair reverse-phase liquid chromatographic/tandem mass spectrometry method for the determination of an 18-mer phosphorothioate oligonucleotide in mouse liver tissue.
2005
Comparison of A+T-rich oligonucleotides with and without self-complementary sequence using ion-pair reversed-phase high-performance liquid chromatography/tandem electrospray ionization mass spectrometry.
2005
Simultaneous determination of unmodified sevoflurane and of its metabolite hexafluoroisopropanol in urine by headspace sorptive extraction-thermal desorption-capillary gas chromatography-mass spectrometry.
2005 Apr 15
Hairpin folding dynamics: the cold-denatured state is predisposed for rapid refolding.
2005 Aug 2
Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice.
2005 Feb 2
Membrane protein and peptide sample handling for MS analysis using a structured MALDI target.
2005 Jan
Micellar aggregates formed following the addition of hexafluoroisopropanol to phospholipid membranes.
2005 Jan 18
Experimental and computational studies of hydrogen bonding and proton transfer to [Cp*Fe(dppe)H].
2005 Jan 21
Simultaneous determination of pyrethroid and pyrethrin metabolites in human urine by gas chromatography-high resolution mass spectrometry.
2005 Jan 25
Amyloid-beta protofibrils differ from amyloid-beta aggregates induced in dilute hexafluoroisopropanol in stability and morphology.
2005 Jan 28
Amyloid-beta aggregates formed at polar-nonpolar interfaces differ from amyloid-beta protofibrils produced in aqueous buffers.
2005 Jul
Effect of detergents and hexafluoroisopropanol on the conformation of a non-helical and a helical plant protease inhibitor.
2005 Jul
Co-electrospun nanofiber fabrics of poly(L-lactide-co-epsilon-caprolactone) with type I collagen or heparin.
2005 Jul-Aug
Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential.
2005 Jun
Characterization of a common intermediate of pea lectin in the folding pathway induced by TFE and HFIP.
2005 May 25
Synthetic studies toward ecteinascidin 743.
2005 May 27
Effects of electrospinning and solution casting protocols on the secondary structure of a genetically engineered dragline spider silk analogue investigated via Fourier transform Raman spectroscopy.
2005 May-Jun
Effect of hexafluoroisopropanol alcohol on the structure of melittin: a molecular dynamics simulation study.
2005 Oct
HFIP-induced structures and assemblies of the peptides from the transmembrane domain 4 of membrane protein Nramp1.
2006
A new class of glucosidase inhibitor: analogues of the naturally occurring glucosidase inhibitor salacinol with different ring heteroatom substituents and acyclic chain extension.
2006 Apr 14
Recovery and purification of highly aggregation-prone disulfide-containing peptides: application to islet amyloid polypeptide.
2006 Apr 15
A screening procedure for the solubilization of chloroplast membrane proteins from the marine green macroalga Ulva lactuca using RP-HPLC-MALDI-MS.
2006 Aug 15
Biomimetic nanofibrous scaffolds: preparation and characterization of PGA/chitin blend nanofibers.
2006 Feb
The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: a step by step conformational analysis suggests the location of beta conformation seeding.
2006 Feb
Methoxy-substituted stilbenes, styrenes, and 1-arylpropenes: photophysical properties and photoadditions of alcohols.
2006 Feb 17
Different spectral signatures of octapeptide 3(10)- and alpha-helices revealed by two-dimensional infrared spectroscopy.
2006 Mar 30
1JCH correlates with alcohol hydrogen bond strength.
2006 Mar 31
Biomimetic nanofibrous scaffolds: preparation and characterization of chitin/silk fibroin blend nanofibers.
2006 May 30
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:09:51 GMT 2025
Edited
by admin
on Mon Mar 31 19:09:51 GMT 2025
Record UNII
3D632GYQ50
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SEVOFLURANE RELATED COMPOUND C
USP-RS  
Preferred Name English
1,1,1,3,3,3-HEXAFLUOROISOPROPANOL
Common Name English
ETHANOL, 2,2,2-TRIFLUORO-1-(TRIFLUOROMETHYL)-
Systematic Name English
SEVOFLURANE IMPURITY C [EP IMPURITY]
Common Name English
HEXAFLUORO-2-PROPANOL
Systematic Name English
2-PROPANOL, 1,1,1,3,3,3-HEXAFLUORO-
Systematic Name English
HEXAFLUOROISOPROPYL ALCOHOL
Systematic Name English
BIS(TRIFLUOROMETHYL)METHANOL
Systematic Name English
HEXAFLUOROISOPROPANOL
Systematic Name English
SEVOFLURANE RELATED COMPOUND C [USP-RS]
Common Name English
1,1,1,3,3,3-HEXAFLUOROPROPANOL
Common Name English
2,2,2-TRIFLUORO-1-(TRIFLUOROMETHYL)ETHANOL
Systematic Name English
2H-HEXAFLUOROISOPROPANOL
Common Name English
HEXAFLUORO-2-PROPANOL, 1,1,1,3,3,3-
Systematic Name English
1,1,1,3,3,3-HEXAFLUOROISOPROPYL ALCOHOL
Common Name English
NSC-96336
Code English
1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL
Systematic Name English
1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPANE
Systematic Name English
Code System Code Type Description
EPA CompTox
DTXSID1022134
Created by admin on Mon Mar 31 19:09:51 GMT 2025 , Edited by admin on Mon Mar 31 19:09:51 GMT 2025
PRIMARY
CAS
920-66-1
Created by admin on Mon Mar 31 19:09:51 GMT 2025 , Edited by admin on Mon Mar 31 19:09:51 GMT 2025
PRIMARY
NSC
96336
Created by admin on Mon Mar 31 19:09:51 GMT 2025 , Edited by admin on Mon Mar 31 19:09:51 GMT 2025
PRIMARY
PUBCHEM
13529
Created by admin on Mon Mar 31 19:09:51 GMT 2025 , Edited by admin on Mon Mar 31 19:09:51 GMT 2025
PRIMARY
RS_ITEM_NUM
1612594
Created by admin on Mon Mar 31 19:09:51 GMT 2025 , Edited by admin on Mon Mar 31 19:09:51 GMT 2025
PRIMARY
WIKIPEDIA
Hexafluoroisopropanol
Created by admin on Mon Mar 31 19:09:51 GMT 2025 , Edited by admin on Mon Mar 31 19:09:51 GMT 2025
PRIMARY
FDA UNII
3D632GYQ50
Created by admin on Mon Mar 31 19:09:51 GMT 2025 , Edited by admin on Mon Mar 31 19:09:51 GMT 2025
PRIMARY
ECHA (EC/EINECS)
213-059-4
Created by admin on Mon Mar 31 19:09:51 GMT 2025 , Edited by admin on Mon Mar 31 19:09:51 GMT 2025
PRIMARY
CHEBI
63104
Created by admin on Mon Mar 31 19:09:51 GMT 2025 , Edited by admin on Mon Mar 31 19:09:51 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> METABOLITE
Related Record Type Details
PARENT -> IMPURITY
EP