Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | Hf.2O |
| Molecular Weight | 210.49 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[O--].[O--].[Hf+4]
InChI
InChIKey=WIHZLLGSGQNAGK-UHFFFAOYSA-N
InChI=1S/Hf.2O/q+4;2*-2
| Molecular Formula | Hf |
| Molecular Weight | 178.49 |
| Charge | 4 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | HO |
| Molecular Weight | 17.0073 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Hafnium oxide is a radio enhancer; its nanoparticles (NBTXR3) were designed for high dose energy deposition within cancer cells when exposed to ionizing radiation. When activated by radiotherapy (RT), NBTXR3 allows for a higher energy deposit than RT alone, yielding an increased tumoral cell death. Nanocrystals of hafnium oxide are under investigation in phase II/III in patients with locally advanced soft tissue sarcoma (STS) of the extremity and trunk wall. In addition, NBTXR3, nanoparticles are being studied in phase I/II in patients with head and neck cancer; liver cancer; prostate cancer and rectal cancer.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| New materials for optical thin films. | 1976 Oct 1 |
|
| Hafnium oxide nanoparticles: toward an in vitro predictive biological effect? | 2014 Jun 30 |
|
| First-in-Human Study Testing a New Radioenhancer Using Nanoparticles (NBTXR3) Activated by Radiation Therapy in Patients with Locally Advanced Soft Tissue Sarcomas. | 2017 Feb 15 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:43:12 GMT 2023
by
admin
on
Fri Dec 15 19:43:12 GMT 2023
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| Record UNII |
3C4Z4KG52T
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| Record Status |
Validated (UNII)
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| Record Version |
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12055-23-1
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C98280
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158931
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235-013-2
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159422
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DTXSID70893204
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300000044788
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Hafnium oxide
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3C4Z4KG52T
Created by
admin on Fri Dec 15 19:43:12 GMT 2023 , Edited by admin on Fri Dec 15 19:43:12 GMT 2023
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
Hafnium oxide-containing nanoparticles accumulate into the tumor cells. Subsequent application of radiation beams to the tumor tissue causes HfO2 particles to emit huge amounts of electrons. This results in the formation of free radicals within the tumor cells, which in turn causes targeted destruction of the cancer cells.
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