LAGATIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C33H58N10O9
Molecular Weight	738.8752
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C)C(N)=O

InChI

InChIKey=WNDMGDURKQLJNM-DHCXFDNTSA-N

InChI=1S/C33H58N10O9/c1-17(2)25(41-28(47)20-10-7-15-37-20)31(50)42-26(19(4)44)32(51)40-22(9-5-6-14-34)33(52)43-16-8-11-23(43)30(49)39-21(12-13-24(35)45)29(48)38-18(3)27(36)46/h17-23,25-26,37,44H,5-16,34H2,1-4H3,(H2,35,45)(H2,36,46)(H,38,48)(H,39,49)(H,40,51)(H,41,47)(H,42,50)/t18-,19-,20+,21+,22+,23+,25+,26+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C33H58N10O9
Molecular Weight	738.8752
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1426876 | https://www.ncbi.nlm.nih.gov/pubmed/7991443 | https://www.ncbi.nlm.nih.gov/pubmed/10704721

LAGATIDE, a heptapeptide, is a short C-terminal analog of sorbin. It has proabsorptive and antisecretory effect in the different parts of the intestine. It was under clinical evaluation for the treatment of chronic diarrhea.

Originator

Approval Year

PubMed

Title	Date	PubMed
Inhibitory effect of sorbin on pepsin secretion in conscious cats and rabbits.	2000-01	10704721
Immunometric assay of BN 52080, a heptapeptide C-terminal analogue of sorbin.	1995	7651898
Pharmacokinetics and organ distribution of the sorbin C-terminal peptides.	1994	7991443
Effect of sorbin on duodenal absorption of water and electrolytes in the rat.	1992-11	1426876

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:21:47 GMT 2025` Edited by `admin` on `Mon Mar 31 19:21:47 GMT 2025`
Record UNII	3B91V02Q5G
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LAGATIDE

Official Name

English

BN-52080

Preferred Name

English

L-PROLYL-L-VALYL-L-THREONYL-L-LYSYL-L-PROLYL-L-GLUTAMINYL-D-ALANINAMIDE

Common Name

English

Lagatide [WHO-DD]

Common Name

English

lagatide [INN]

Common Name

English

BN52080

Code

English

Code System Code Type Description

EPA CompTox

DTXSID10166267