LAGATIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C33H58N10O9
Molecular Weight	738.8752
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C)C(N)=O

InChI

InChIKey=WNDMGDURKQLJNM-DHCXFDNTSA-N

InChI=1S/C33H58N10O9/c1-17(2)25(41-28(47)20-10-7-15-37-20)31(50)42-26(19(4)44)32(51)40-22(9-5-6-14-34)33(52)43-16-8-11-23(43)30(49)39-21(12-13-24(35)45)29(48)38-18(3)27(36)46/h17-23,25-26,37,44H,5-16,34H2,1-4H3,(H2,35,45)(H2,36,46)(H,38,48)(H,39,49)(H,40,51)(H,41,47)(H,42,50)/t18-,19-,20+,21+,22+,23+,25+,26+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C33H58N10O9
Molecular Weight	738.8752
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1426876 | https://www.ncbi.nlm.nih.gov/pubmed/7991443 | https://www.ncbi.nlm.nih.gov/pubmed/10704721

LAGATIDE, a heptapeptide, is a short C-terminal analog of sorbin. It has proabsorptive and antisecretory effect in the different parts of the intestine. It was under clinical evaluation for the treatment of chronic diarrhea.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effect of sorbin on duodenal absorption of water and electrolytes in the rat.	1992 Nov	1426876
Pharmacokinetics and organ distribution of the sorbin C-terminal peptides.	1994	7991443
Immunometric assay of BN 52080, a heptapeptide C-terminal analogue of sorbin.	1995	7651898

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:48:50 GMT 2023` Edited by `admin` on `Fri Dec 15 18:48:50 GMT 2023`
Record UNII	3B91V02Q5G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LAGATIDE

Official Name

English

L-PROLYL-L-VALYL-L-THREONYL-L-LYSYL-L-PROLYL-L-GLUTAMINYL-D-ALANINAMIDE

Common Name

English

Lagatide [WHO-DD]

Common Name

English

lagatide [INN]

Common Name

English

BN52080

Code

English

BN-52080

Code

English

Code System Code Type Description

EPA CompTox

DTXSID10166267