Zadoprubart

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 15:34:58 GMT 2025` Edited by `admin` on `Wed Apr 02 15:34:58 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	39T86A9MVJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Zadoprubart

Official Name

English

H-gamma4 heavy chain humanized (1-451) [VH (Homo sapiens IGHV1-69*08 (80.6%) -(IGHD) -IGHJ6*05 (92.3%) A127>S (123), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10(CH1 (125-222), hinge 1-12 S10>P (232)

Preferred Name

English

zadoprubart [INN]

Common Name

English

immunoglobulin G4-kappa, anti-[Homo sapiens BTLA (B and T lymphocyte attenuator, BTLA1, CD272)], humanized monoclonal antibody

Common Name

English

Immunoglobulin G4, anti-(human/Macaca fascicularis protein BTLA (B-and T-lymphocyte attenuator)) (human-Mus musculus monoclonal ANB032 ?4-chain), disulfide with human-Mus musculus monoclonal ANB032 ?-chain, dimer

Common Name

English

Code System Code Type Description

FDA UNII

39T86A9MVJ

Created by admin on Wed Apr 02 15:34:58 GMT 2025 , Edited by admin on Wed Apr 02 15:34:58 GMT 2025

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NCI_THESAURUS

C211724

Created by admin on Wed Apr 02 15:34:58 GMT 2025 , Edited by admin on Wed Apr 02 15:34:58 GMT 2025

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CAS

2904575-77-3

Created by admin on Wed Apr 02 15:34:58 GMT 2025 , Edited by admin on Wed Apr 02 15:34:58 GMT 2025

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SMS_ID

300000049696

Created by admin on Wed Apr 02 15:34:58 GMT 2025 , Edited by admin on Wed Apr 02 15:34:58 GMT 2025

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INN

13268

Created by admin on Wed Apr 02 15:34:58 GMT 2025 , Edited by admin on Wed Apr 02 15:34:58 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_138	4_214
2_151	2_207
2_265	2_325
1_138	3_214
2_371	2_429
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_151	1_207
1_230	2_230
1_233	2_233
1_265	1_325
1_371	1_429

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_301
N	2_301

Related Record Type Details


					39T86A9MVJ

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_451] [2_451]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL